Excessive visceral fat accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases. The visceral fat is highly susceptible to the availability of external nutrients. Moreover, adipose OGT overexpression inhibits lipolysis and promotes diet-induced obesity. These findings establish an essential role for OGT in adipose tissue homeostasis and indicate a unique potential for targeting O-GlcNAc signaling in the treatment of obesity.
- January 10, 2020
In obese individuals, cellular "doormen" open the gates far too wide in certain key fat cells, known as visceral fat cells, letting in too many carbohydrates without first burning off lipids. This leads to a ballooning of the size of visceral fat cells in the belly.
- November 14, 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic HomeostasisSource: Cell Metabolism
A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation.
- September 05, 2019
The researchers reaffirmed that inflammation occurs in the hypothalamus as early as three days after consumption of a high-fat diet, even before the body begins to display signs of obesity.
- April 01, 2019Source: Speaking of Research
A special issue of the American Journal of Primatology emphasizes the value of marmosets models for aging research.
- October 26, 2018Source: The Hill
Animal-based research is a huge return on investment of taxpayer dollars.
- July 31, 2018
In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation.
- July 24, 2018
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
- June 22, 2018
When it met on June 8, 2018 the Yale Corporation approved the following medical school faculty for endowed professorships.
- March 07, 2018Source: Research Features
Humans are innately sociable mammals. However, almost all of our understanding of the neural basis of social interaction has been carried out with individual participants, limiting our knowledge of how our brains react to other humans. Joy Hirsch, Professor of Neuroscience at the Yale School of Medicine and University College London, has embarked on a truly pioneering research programme using new neuroimaging technology to study the human brain as it interacts with others.