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Yale researchers show how the liver can control the brain and behavior

A new Yale study found that the liver plays a major role in regulating feeding behavior in mice, a discovery that could have implications for people with eating disorders and metabolic diseases. The study, which was done in collaboration with colleagues in Germany, also adds to a growing body of evidence that shows the most advanced part of the brain, the cerebral cortex, is affected by the rest of the body, not just the other way around.

Source: YaleNews
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  • Studying schizophrenia in plants? Yale researchers are giving it a shot

    What if scientists could study human psychiatric illness in plants? Yale researchers think it’s possible and they’ve taken an important first step. In a study published June 2 in Cellular and Molecular Life Sciences, they investigated a gene very similar in both plants and mammals and looked at how it affects behavior in each.

    Source: YaleNews
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  • What is a brain? For Yale authors, conversation brings new clarity

    For a new book, two Yale researchers and a colleague from Oxford take a novel approach to explore the interrelated complexities of the brain: They talk it out. In “Body, Brain, Behavior: Three Views and a Conversation,” co-authored by Tamas Horvath and Joy Hirsch of the Yale School of Medicine, and Zoltán Molnár, a professor of developmental neuroscience at the University of Oxford, the three researchers each share a traditional chapter related to their disciplines: endocrine physiology, social neuroscience, and developmental neuroscience. But connecting the chapters is a series of transcripts of weekly conversations they held over two years.

    Source: YaleNews
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  • 2021 Recipient of the Judah Folkman Award in Vascular Biology

    The NAVBO Meritorious Awards Committee, the Scientific Advisory Board, and the NAVBO Council announce with pleasure the selection of Carlos Fernández-Hernando, PhD, as the recipient of the 2021 Judah Folkman Award in Vascular Biology. This award recognizes outstanding contributions from vascular biologists who are at mid-career (within fifteen years of their first faculty appointment).

    Source: North American Vascular Biology Organization
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  • Immune Cell Betrayal Explains Why It Gets Colder as We Age

    With age, people become more susceptible to cold as inflammation and metabolic problems which can lead to a host of chronic diseases. Researchers at Yale and the University of California-San Francisco have found one culprit in this process — the same immune cells within fat that are designed to protect us from cold temperatures.

    Source: YaleNews
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  • O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

    Abstract Excessive visceral fat accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases. The visceral fat is highly susceptible to the availability of external nutrients. Moreover, adipose OGT overexpression inhibits lipolysis and promotes diet-induced obesity. These findings establish an essential role for OGT in adipose tissue homeostasis and indicate a unique potential for targeting O-GlcNAc signaling in the treatment of obesity.

    Source: Nature Communications
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