Yale-led study finds surprise link between metabolism and immunity
In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation.
Two brain neuroscience: understanding our social selves
Humans are innately sociable mammals. However, almost all of our understanding of the neural basis of social interaction has been carried out with individual participants, limiting our knowledge of how our brains react to other humans. Joy Hirsch, Professor of Neuroscience at the Yale School of Medicine and University College London, has embarked on a truly pioneering research programme using new neuroimaging technology to study the human brain as it interacts with others.Source: Research Features
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Blavatnik Fund awards grants for innovation
Several faculty members won research grants from the Blavatnik Fund for Innovation at Yale at the fourth annual Yale Innovation Summit on May 10. The summit, presented by the Office of Cooperative Research (OCR) and Yale Entrepreneurial Institute, provides a window into an expanding entrepreneurial ecosystem at Yale.
Could a ketogenic diet alleviate gout?
More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, neutrophils. These periods of immune reactivation are known as flares, and are driven by a protein complex called the NLRP3 inflammasome.
Can a cancer drug treat a rare cardiac disease?
A study by a Yale scientis suggests that dasatinib and similar drugs at low doses could be effective treatment for cardiovascular defects related to Noonan syndrome (NS), a genetic disorder that results in severe heart defects, and should be considered for clinical trials.
Yale Researchers Study Life-Extending Hormone
Beginning in 2007, Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine, and a team of researchers at his lab began studying the hormone and its effects on mice genetically engineered to produce more of it.Source: Connecticut
Constipated? Study finds surprising cause
A Yale-led study has shown a surprising link between constipation and herpes infection. The finding, published June 8 in Cell Host & Microbe, advances the science on herpes, and could help patients with chronic gastrointestinal diseases with no clear cause.
A mouse’s house may ruin experiments
It’s no secret that therapies that look promising in mice rarely work in people. But too often, experimental treatments that succeed in one mouse population do not even work in other mice, suggesting that many rodent studies may be flawed from the start.Source: A mouse’s house may ruin experiments
Lasers, magnetism allow glimpses of the human brain at work
The work of Joy Hirsch, PhD is featured in an Associated Press article on the White House BRAIN Initiative. Hirsch is professor of psychiatry, of comparative medicine and of neurobiology at Yale School of Medicine.Source: Associated Press
Researchers Identify Cellular Origins of Fat
A study led by Ryan Berry GRD ’15 and associate research scientist Matthew Rodeheffer from the Yale School of Medicine determined that a specific type of cell, the CD24+ cell, differentiates into fat cells in mice. This development answers many questions regarding the origins of body fat, which is the key factor in highly prevalent conditions such as diabetes and obesity.Source: The Yale Daily News
New fat cells created quickly, but losing them …
Once fat cells form, they might shrink during weight loss, but they do not disappear, a fact that has derailed many a diet. Yale researchers in the March 2 issue of the journal Nature Cell Biology describe how — and just how quickly — those fat cells are created in the first place.
Antifreeze protein from ticks fights frostbite in mice
A protein that protects ticks from freezing temperatures also prevents frostbite when introduced in mice, a Yale-led study has found. The research is the first to demonstrate the protein’s ability to boost frostbite resistance in an adult mammal.
Anti-inflammatory mechanism of dieting and fasting revealed
Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease.
Eleven young investigators receive grants to pursue brain and behavior research
Eleven Yale investigators have received Young Investigator Grants from the Brain & Behavior Research Foundation (formerly NARSAD). The grants are among $12 million in new funding intended to lead to breakthroughs in understanding and treating mental illness.
Teens' tendency to take risks due not to attraction to danger, but to tolerance of ambiguity, says study
A new study by Yale School of Medicine researchers and their colleagues finds that adolescents commonly take more risks than younger children and adults because they are more willing to accept risks when consequences are unknown, rather than because they are attracted to danger, as often assumed.
Yale Study: Trends in the Use of Buprenorphine in US Emergency Departments, 2002-2017
Greg Rhee, PhD, Assistant Professor Adjunct, is first author of a paper published in JAMA Network Open that examines the trends of buprenorphine use in emergency departments in the United States from 2002 (when it was approved) through 2017.Source: JAMA Network Open