Kaelyn Sumigray, PhD
Assistant Professor of GeneticsCards
Appointments
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
About
Titles
Assistant Professor of Genetics
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Biography
Kaelyn Sumigray earned her B.S. from Union College in 2006. She obtained her Ph.D. in 2011 from the Department of Cell Biology at Duke University. She was a postdoctoral fellow first at the University of North Carolina at Chapel Hill, from 2012-2013, where she was awarded an NIH Kirschstein postdoctoral fellowship, followed by a postdoctoral fellow at Duke University with Terry Lechler from 2013-2019, where she was awarded a Dermatology Foundation Research Grant. She joined the Yale faculty in 2019.
Appointments
Genetics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral associate
- Duke University (2019)
- Postdoctoral Fellow
- University of North Carolina at Chapel Hill (2013)
- PhD
- Duke University, Cell Biology (2011)
- BS
- Union College, Biology (2006)
Research
Overview
Medical Subject Headings (MeSH)
- View Lab Website
Sumigray lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Nadia Ameen, MBBS
Timothy Nottoli, PhD
Jing Yan, PhD
Maria Figetakis
M. Elizabeth Deerhake, MD, PhD
Robert Cowles, MD
Cell Adhesion
Stem Cells
Morphogenesis
Cell Polarity
Intestine, Small
Cell Shape
Publications
2024
Redefining intestinal stemness: The emergence of a new ISC population
Li M, Sumigray K. Redefining intestinal stemness: The emergence of a new ISC population. Cell 2024, 187: 2900-2902. PMID: 38848673, DOI: 10.1016/j.cell.2024.04.021.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsA Coculture System for Modeling Intestinal Epithelial-Fibroblast Crosstalk
Lee R, Li M, Figetakis M, Sumigray K. A Coculture System for Modeling Intestinal Epithelial-Fibroblast Crosstalk. Methods In Molecular Biology 2024, 1-16. PMID: 38700834, DOI: 10.1007/7651_2024_544.Peer-Reviewed Original ResearchAltmetric978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE
Jin J, Reis D, Muiler C, Sumigray K, Ameen N. 978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE. Gastroenterology 2024, 166: s-236. DOI: 10.1016/s0016-5085(24)01027-8.Peer-Reviewed Original Research
2023
Generation and Manipulation of Rat Intestinal Organoids.
Zagoren E, Santos A, Ameen N, Sumigray K. Generation and Manipulation of Rat Intestinal Organoids. Journal Of Visualized Experiments 2023 PMID: 37427951, DOI: 10.3791/65343.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsAntibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner
Salvi P, Shaughnessy M, Sumigray K, Cowles R. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. AJP Gastrointestinal And Liver Physiology 2023, 325: g80-g91. PMID: 37158470, DOI: 10.1152/ajpgi.00113.2022.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSerotonin activitySERT protein expressionSerotonin potentiationEpithelial proliferationSerotonin transporterEndogenous serotoninVillus heightMicrobial depletionIntestinal epithelial growthProtein expressionEpithelial growthSerotonin-dependent mechanismIntestinal villus heightSmall intestine resultsIntestinal surface areaSmall intestinal villiSmall intestinal cryptsIntestinal pathologyPara-chlorophenylalanineISC numbersSerotonin synthesisIntestinal homeostasisEpithelial expressionMouse modelAnimal modelsSa1225 BIFUNCTIONALITY OF UNCONVENTIONAL MYOSIN 5B (MYO5B) IN INTESTINAL PHYSIOLOGY: ROLE IN MVID AND GENERATION OF CFTR HIGH EXPRESSER (CHE) CELLS IN MICE.
Santos A, dos Reis D, Sumigray K, Ameen N. Sa1225 BIFUNCTIONALITY OF UNCONVENTIONAL MYOSIN 5B (MYO5B) IN INTESTINAL PHYSIOLOGY: ROLE IN MVID AND GENERATION OF CFTR HIGH EXPRESSER (CHE) CELLS IN MICE. Gastroenterology 2023, 164: s-331. DOI: 10.1016/s0016-5085(23)01758-4.Peer-Reviewed Original ResearchVibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization
Huang X, Nero T, Weerasekera R, Matej K, Hinbest A, Jiang Z, Lee R, Wu L, Chak C, Nijjer J, Gibaldi I, Yang H, Gamble N, Ng W, Malaker S, Sumigray K, Olson R, Yan J. Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization. Nature Communications 2023, 14: 2104. PMID: 37055389, PMCID: PMC10102183, DOI: 10.1038/s41467-023-37660-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBiofilm matrix exopolysaccharideFacilitate host colonizationVibrio cholerae biofilmsΒ-propeller domainMatrix exopolysaccharideModular domainsHost colonizationRedundant rolesDistinct functionsAbiotic surfacesAdhesive proteinsHost surfaceHuman pathogensVibrio choleraeAdhesinsBacterial biofilmsHost tissuesColonization modelColonizationBAP1BiofilmsPathogensAntibiotic resistanceRBMCDomainCFTR High Expresser Cells in cystic fibrosis and intestinal diseases
dos Reis D, Dastoor P, Santos A, Sumigray K, Ameen N. CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Heliyon 2023, 9: e14568. PMID: 36967909, PMCID: PMC10031467, DOI: 10.1016/j.heliyon.2023.e14568.Peer-Reviewed Original ResearchCitationsConceptsCystic fibrosisIntestinal diseaseCystic fibrosis transmembrane conductance regulatorQuality of lifeIntestinal dysfunctionGastrointestinal diseasesIntestinal physiologyFibrosisDiseasePathophysiologyFibrosis transmembrane conductance regulatorTransmembrane conductance regulatorCFTR leadConductance regulator
2022
Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut
Bara A, Chen L, Ma C, Underwood J, Moreci R, Sumigray K, Sun T, Diao Y, Verzi M, Lechler T. Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut. Development 2022, 149 PMID: 36504079, PMCID: PMC10112929, DOI: 10.1242/dev.201251.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNutrient uptakeTranscription factorsMaf family transcription factorsMajor transcriptional changesFamily transcription factorsLoss of Blimp1Transcription factor MafBMaf proteinsCell fateTranscriptional regulatorsTranscriptional changesRNA-seqMaster regulatorEnterocyte genesFatty acid oxidationGene expressionPeroxisome numberAdult intestineMetabolic pathwaysMolecular componentsSubsequent degradationMaf factorsC-MafSimilar defectsIntestinal enterocytesLoss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID)
Ahsan K, dos Reis DC, Barbieri A, Sumigray KD, Nottoli T, Salas PJ, Ameen NA. Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID). Journal Of Clinical Medicine 2022, 11: 4179. PMID: 35887942, PMCID: PMC9319011, DOI: 10.3390/jcm11144179.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMicrovillus inclusion diseaseSevere diarrheaInclusion diseaseFluid secretionCystic fibrosis transmembrane conductance regulatorDouble knockout miceMicrovillus inclusionsGlucocorticoid-inducible kinase 1Carbohydrate malabsorptionKnockout miceIntestinal carbohydrateDiarrheaDiarrheal diseaseMalabsorptionMiceVillus enterocytesDiseaseLoss of MYO5BFunction mutationsApical cystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorKinase 1SecretionIntestineTransmembrane conductance regulator
Academic Achievements and Community Involvement
activity American Heart Association
Peer Review Groups and Grant Study SectionsReviewerDetails2022 - Presentactivity eLife
Journal ServiceReviewerDetails2022 - Presentactivity Science
Journal ServiceReviewerDetails2023 - Presentactivity Nature Cell Biology
Journal ServiceReviewerDetails2021 - Presentactivity Journal of Clinical Investigation
Journal ServiceReviewerDetails2022 - Present
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