Enock Teefe, MD
Psychiatry ResidentCards
Additional Titles
Neuroscience Research Training Program, Yale Department of Psychiatry
Contact Info
About
Titles
Psychiatry Resident
Neuroscience Research Training Program, Yale Department of Psychiatry
Biography
I went to medical school with the intention of becoming an oncologist, building on knowledge I developed in biotech industry research making DNA sequencing assays for clinical research applications. That all changed when in medical school, during a research year-off working at the NIH, I discovered the emerging value of using genomics to uncover the neurogenetic mechanisms underlying serious mental illness.
During that research year, working in Dr. Karen Faith Berman’s lab at NIMH, I conducted a neuroimaging-genetics study that showed for the first time a gene-dosage effect on regional white matter myelination in a clinical cohort of children with the 7q11.23 genetic Copy Number Variation (CNV). The knowledge, experience and amazing mentorship from Dr.Berman’s lab emboldened my desire to become a physician-scientist within psychiatry.
For residency training, I chose Yale for it’s vibrant research community within the Psychiatry department and the Child Study Center, the ample protected research time provided during residency, and the opportunity for PhD or Master’s level training through the Investigative Medicine Program. At the start of my PGY-2 year, I joined the lab of Dr.Tom Fernandez which focuses on the genomics of childhood onset neuropsychiatric disorders like Tourettes, OCD, ADHD and Schizophrenia. I am currently working on a project investigating genome wide differential gene expression in OCD patients, with the goal of identifying gene networks and distinct biological pathways that may underlie OCD pathology.
In the future, I look to further develop research skills in genomics and transcriptomics with the long term goal of becoming an independent investigator working in translational psychiatric genomics.
Having grown-up in Uganda, and done college in California, I’ve come to love and appreciate the season changes in the North East! I’m still discovering good running trails in the New Haven area and I continue to be amazed by the variety of restaurants with great food in such a small city.
Appointments
Departments & Organizations
Education & Training
- Psychiatry Research Fellow
- Yale School of Medicine (2024)
- Adult Psychiatry Resident
- Yale University School of Medicine (2023)
- MD
- Rosalind Franklin University (2019)
- BS
- University of California Los Angeles, Bioengineering (2012)
- AS
- Los Medanos College, Biology, Mathematics and Liberal Arts (2009)
Board Certifications
Psychiatry
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 2023
Research
Publications
2018
Differences in Brain Myelination Patterns Associated With 7q11. 23 Copy Number Variations
Teefe, E., Gregory, M., Kippenhan, J. S., Nash, T., Grogans, S., Elliott, S., ... & Berman, K. (2018, December). Differences in Brain Myelination Patterns Associated With 7q11. 23 Copy Number Variations. In NEUROPSYCHOPHARMACOLOGY (Vol. 43, pp. S99-S100). MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND: NATURE PUBLISHING GROUP.Peer-Reviewed Original ResearchAggregating genetic and brain networks associated with risk for schizophrenia via spectral clustering of working memory activation and pgc2 loci
Gregory, M., Kohn, P., Kippenhan, J. S., Teefe, E., Morse, J., Mattay, V., ... & Berman, K. (2018). S215. Aggregating genetic and brain networks associated with risk for schizophrenia via spectral clustering of working memory activation and pgc2 loci. Biological Psychiatry, 83(9), S431.Peer-Reviewed Original Research
2015
Bilateral femoral osteolytic lesions in a patient with type 3 Gaucher disease
Teefe E, Kim J, Lopez G, Sidransky E. Bilateral femoral osteolytic lesions in a patient with type 3 Gaucher disease. Molecular Genetics And Metabolism Reports 2015, 5: 107-109. PMID: 26693402, PMCID: PMC4683618, DOI: 10.1016/j.ymgmr.2015.10.008.Peer-Reviewed Original ResearchCitations
2014
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, Yates L, Jamal-Hanjani M, Shafi S, Murugaesu N, Rowan AJ, Grönroos E, Muhammad MA, Horswell S, Gerlinger M, Varela I, Jones D, Marshall J, Voet T, Van Loo P, Rassl DM, Rintoul RC, Janes SM, Lee SM, Forster M, Ahmad T, Lawrence D, Falzon M, Capitanio A, Harkins TT, Lee CC, Tom W, Teefe E, Chen SC, Begum S, Rabinowitz A, Phillimore B, Spencer-Dene B, Stamp G, Szallasi Z, Matthews N, Stewart A, Campbell P, Swanton C. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 2014, 346: 251-256. PMID: 25301630, PMCID: PMC4636050, DOI: 10.1126/science.1253462.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-small cell lung cancerOperable non-small cell lung cancerHuman non-small cell lung cancerSubclonal diversificationDriver mutationsCell lung cancerLung cancer evolutionFormer smokersDismal prognosisLung cancerTreatment successTumor latencyCarcinogen exposureCytidine deaminase activityCopy number alterationsClinical detectionSmokersIntratumor heterogeneityTumorsNumber alterationsRelative decreaseDeaminase activityMutationsTemporal dissectionPrognosisDetection of hepatitis C (HCV) NS5A and NS3 drug resistance associated mutations (RAMs) and polymorphisms by deep sequencing in subjects from BMS AI452008 Part A (the D-LITE Study)
Kozal, M. J., Chiarella, J., Lee, C. C., Parikh, C., Teefe, E., Kyriakides, T., & Harkins, T. T. (2014, January). Detection of hepatitis C (HCV) NS5A and NS3 drug resistance associated mutations (RAMs) and polymorphisms by deep sequencing in subjects from BMS AI452008 Part A (the D-LITE Study). In ANTIVIRAL THERAPY (Vol. 19, pp. A48-A48). 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND: INT MEDICAL PRESS LTD.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
honor SOBP Travel Fellowship Award
National AwardSociety of Biological PsychiatryDetails05/09/2024honor Thomas P. Detre Award for Psychiatric Research
Yale School of Medicine AwardDepartment of Psychiatry, Yale School of MedicineDetails05/12/2022United Stateshonor The Ira R. Levine Award for Clinical Excellence
Yale School of Medicine AwardDepartment of Psychiatry, Yale School of MedicineDetails06/17/2021United Stateshonor Medical Research Scholars Program
National AwardNational Institutes of HealthDetails08/01/2017United Stateshonor Gold Humanism Honor Society
National AwardRosalind Franklin UniversityDetails06/30/2017United States
Links & Media
News
- July 19, 2023
2023 Residents, Fellows Honored at Annual Commencement Ceremonies
- January 16, 2023
Enock Teefe and José Jaime Martínez-Magaña Receive 2023 Kavli Postdoctoral Award for Academic Diversity
- May 12, 2022
Lustman, Detre Award Recipients Announced
- August 25, 2021
Global Mental Health Program Seminar Series Receives Award from Kempf Memorial Fund