The purpose of the Yale Cancer Center (YCC) Data and Safety Monitoring Committee (DSMC) is to provide ongoing data and safety monitoring for all interventional cancer clinical trials, which include therapeutic, intervention prevention and intervention supportive care studies.
The purpose of the Pediatric Protocol Review Committee is to review the scientific validity of proposed studies in children, and to ensure that appropriate and systematic measures to minimize risk to participating subjects are incorporated into the protocols; thereby, voting on and recommending a risk assessment to the Human Investigation Committee (HIC.)
The role of the Science and Safety Committee is to evaluate the scientific merit of clinical research protocols including novelty of the science, impact of the science on the subject area of the protocol, and justification of the utilization of human subjects to answer the scientific question(s) of the protocol.