2021
Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids
Luther JM, Wei DS, Ghoshal K, Peng D, Adler GK, Turcu AF, Nian H, Yu C, Solorzano CC, Pozzi A, Brown NJ. Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids. Hypertension 2021, 77: 1323-1331. PMID: 33583202, PMCID: PMC8320355, DOI: 10.1161/hypertensionaha.120.14808.Peer-Reviewed Original Research
2019
Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis
Choi W, Kim H, Kim M, Cinar R, Yi H, Eun H, Kim S, Choi Y, Lee Y, Kim S, Seo W, Lee J, Shim Y, Kim Y, Yang K, Ryu T, Hwang J, Lee C, Choi H, Gao B, Kim W, Kim S, Kunos G, Jeong W. Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis. Cell Metabolism 2019, 30: 877-889.e7. PMID: 31474565, PMCID: PMC6834910, DOI: 10.1016/j.cmet.2019.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmino Acid Transport System y+AnimalsArachidonic AcidsEndocannabinoidsFatty Liver, AlcoholicFemaleGlutamic AcidGlyceridesHEK293 CellsHep G2 CellsHepatic Stellate CellsHepatocytesHumansLipogenesisMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedReceptor, Cannabinoid, CB1Receptor, Metabotropic Glutamate 5Signal TransductionTransfectionConceptsAlcoholic liver diseaseExpression of metabotropic glutamate receptor 5Pharmacological inhibition of mGluR5Metabotropic glutamate receptor 5Alcoholic steatosisCannabinoid receptor 1Glutamate receptor 5Inhibition of mGluR5Extracellular glutamate levelsGlutamate signalingGlutamate levelsHepatic stellate cellsMGluR5Receptor 5Receptor 1Liver diseaseMetabolic synapsePharmacological inhibitionStellate cellsCystine uptakeCompensatory increaseCysteine deficiencyGlutathione depletionSteatosisMiceEndocannabinoid contributions to alcohol habits and motivation: Relevance to treatment
Gianessi CA, Groman SM, Thompson SL, Jiang M, van der Stelt M, Taylor JR. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction Biology 2019, 25: e12768. PMID: 31056846, PMCID: PMC7790504, DOI: 10.1111/adb.12768.Peer-Reviewed Original Research
2017
Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior
Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ. Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biological Psychiatry 2017, 84: 304-315. PMID: 29458998, PMCID: PMC6023784, DOI: 10.1016/j.biopsych.2017.11.036.Peer-Reviewed Original ResearchConceptsDirect pathway medium spiny neuronsMedium spiny neuronsDorsal striatumIndirect pathway medium spiny neuronsReceptor-expressing medium spiny neuronsStriatal direct pathwayAutism spectrum disorderDiacylglycerol lipase αConditional knockout miceSpectrum disorderGlutamatergic driveSpiny neuronsEndocannabinoid signalingRepetitive groomingSynaptic transmissionMouse modelRepetitive behaviorsKnockout miceExcessive groomingDopamine DBrain regionsStriatumVentral striatumBehavioral effectsTargeted deletion
2014
Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans
Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown NJ. Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins And Other Lipid Mediators 2014, 113: 38-44. PMID: 25173047, PMCID: PMC4253976, DOI: 10.1016/j.prostaglandins.2014.08.001.Peer-Reviewed Original ResearchConceptsInsulin sensitivity indexEpoxyeicosatrienoic acidsInsulin sensitivityHigher insulin sensitivity indexPlasma epoxyeicosatrienoic acidsGlucose-stimulated insulin secretionBody mass indexArg/ArgSoluble epoxide hydrolase activitySoluble epoxide hydrolaseMetabolic syndromeMass indexDisposition indexInsulin resistanceHyperglycemic clampInsulin secretionSensitivity indexEpoxide hydrolase activityEPHX2Hydrolase activitySecretionPhenotyping studiesMetabolic phenotyping studiesEpoxide hydrolaseGenetic variantsRETRACTED ARTICLE: Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors
Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A. RETRACTED ARTICLE: Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors. Neuropsychopharmacology 2014, 39: 2519-2528. PMID: 24820537, PMCID: PMC4207337, DOI: 10.1038/npp.2014.110.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaArachidonic AcidsAttentionCarbon RadioisotopesEndocannabinoidsFearFemaleHumansInterview, PsychologicalMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPolyunsaturated AlkamidesPositron-Emission TomographyRadiopharmaceuticalsReceptor, Cannabinoid, CB1Young Adult
2013
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study
Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Molecular Psychiatry 2013, 18: 1034-1040. PMID: 23670490, PMCID: PMC3752332, DOI: 10.1038/mp.2013.61.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmidesAnalysis of VarianceArachidonic AcidsBrainEndocannabinoidsEthanolaminesFemaleGlyceridesHumansHydrocortisoneImidazolesLogistic ModelsMalePalmitic AcidsPiperidinesPolyunsaturated AlkamidesPyrazolesRadionuclide ImagingReceptor, Cannabinoid, CB1Stress Disorders, Post-TraumaticYoung AdultConceptsPost-traumatic stress disorderVolume of distributionCB1 receptor availabilityPositron emission tomographyHC groupReceptor availabilityTC groupCannabinoid type 1 receptorStress disorderPositron emission tomography studyEvidence-based pharmacotherapyEtiology of PTSDType 1 receptorEmission tomography studiesAnandamide concentrationsElevated brainPeripheral levelsHealthy controlsCB1 receptorsUntreated individualsPET scansAnimal modelsCortisol levelsLifetime historyEmission tomography
2012
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 14966-14971. PMID: 22912404, PMCID: PMC3443187, DOI: 10.1073/pnas.1212887109.Peer-Reviewed Original ResearchMeSH KeywordsAmidesAmidohydrolasesAnalysis of VarianceAnimalsArachidonic AcidsChromatography, LiquidEndocannabinoidsEnergy MetabolismEthanolaminesHypothyroidismImmunoblottingInsulin ResistanceMiceMice, KnockoutPalmitic AcidsPolymerase Chain ReactionPolyunsaturated AlkamidesPPAR gammaTandem Mass SpectrometryThyrotropinThyrotropin-Releasing HormoneThyroxineTriiodothyronineConceptsEctopic lipid storageHepatic insulin resistanceInsulin resistanceEnergy expenditureDiet-induced hepatic insulin resistanceHypothalamic thyrotropin-releasing hormoneFatty acid amide hydrolase knockout miceThyroid-stimulating hormoneThyrotropin-releasing hormoneLipid storageDeiodinase 2 expressionReduced mRNA expressionProtein kinase Cε activationHepatic diacylglycerol contentPituitary thyroid-stimulating hormoneExcess energy storageFAAH deletionKnockout miceReceptor γThyroid axisThyroxine concentrationsMRNA expressionMiceHypothyroidismFAAH
2010
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
Chávez A, Chiu C, Castillo P. TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. Nature Neuroscience 2010, 13: 1511-1518. PMID: 21076423, PMCID: PMC3058928, DOI: 10.1038/nn.2684.Peer-Reviewed Original ResearchConceptsDentate gyrusLong-term depressionInternalization of AMPA receptorsActivation of TRPV-1Postsynaptic long-term depressionExcitatory synaptic transmissionEndocannabinoid receptorsAMPA receptorsTRPV-1TRPV1 activationGyrusSynaptic transmissionDentateClathrin-dependent internalizationReceptorsEndocannabinoidAnandamideDepressionTRPV1
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide
2001
Cannabinoid Antagonists: A Treatment in Search of an Illness
D'Souza D, Kosten T. Cannabinoid Antagonists: A Treatment in Search of an Illness. JAMA Psychiatry 2001, 58: 330-331. PMID: 11296092, DOI: 10.1001/archpsyc.58.4.330.Peer-Reviewed Original Research
1991
Early Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid
Nonomura N, Giebink G, Harada T, Zelterman D, Juhn S. Early Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid. Annals Of Otology Rhinology & Laryngology 1991, 100: 385-388. PMID: 1850967, DOI: 10.1177/000348949110000507.Peer-Reviewed Original ResearchConceptsMiddle ear fluidArachidonic acid metabolitesEar fluidLeukotriene B4Acid metabolitesPneumococcal otitis mediaSubsequent inflammatory responseInflammatory cell chemotaxisStreptococcus pneumoniae organismsMiddle ear inoculationInflammatory cellsOtitis mediaF1 alphaInflammatory responseProstaglandin E2Pneumoniae organismsArachidonate metabolitesArachidonic acidCell chemotaxisEar inoculationEarly biochemical eventsSignificant increaseInitial stimulusHoursMetabolites
1989
IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis.
Zavoico GB, Ewenstein BM, Schafer AI, Pober JS. IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis. The Journal Of Immunology 1989, 142: 3993-9. PMID: 2497185, DOI: 10.4049/jimmunol.142.11.3993.Peer-Reviewed Original ResearchMeSH KeywordsArachidonic AcidArachidonic AcidsCells, CulturedChromatography, Thin LayerCycloheximideDrug SynergismEndothelium, VascularEpoprostenolHistamineHumansInterleukin-1Platelet Activating FactorProstaglandin Endoperoxides, SyntheticProstaglandin H2Prostaglandins HThrombinvon Willebrand FactorEndocytic and Secretory Repertoire of the Lipid-Loaded Macrophage
Montgomery R, Cohn Z. Endocytic and Secretory Repertoire of the Lipid-Loaded Macrophage. Journal Of Leukocyte Biology 1989, 45: 129-138. PMID: 2492592, DOI: 10.1002/jlb.45.2.129.Peer-Reviewed Original ResearchConceptsLipid-laden cellsOil Red O stainingTumor necrosis factorArachidonic acid metabolitesRed O stainingIntracellular lipid poolsWestern blot analysisIntracellular lipid storageMouse peritoneal macrophagesCholesterol levelsNecrosis factorMacrophage functionO stainingScavenger receptorsSecretory functionAcid metabolitesAtherosclerotic arteriesPeritoneal macrophagesFunctional changesFibrinolytic activitySheep erythrocytesCholesterol acceptorsMacrophagesSecretory productsLipid storage
1988
Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation.
Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 1988, 104: 383-9. PMID: 3135629.Peer-Reviewed Original Research
1985
Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
Knazek R, Yee C, Costa J. Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors. International Journal Of Cancer 1985, 36: 143-152. PMID: 2991146, DOI: 10.1002/ijc.2910360204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidArachidonic AcidsChondrosarcomaChromatography, High Pressure LiquidChromatography, Thin LayerHistiocytoma, Benign FibrousHumansHydroxyeicosatetraenoic AcidsMiceMice, NudeNeoplasm TransplantationProstaglandinsRadioimmunoassayRhabdomyosarcomaSarcomaSarcoma, SynovialSoft Tissue NeoplasmsTeratomaConceptsArachidonic acid metabolitesAcid metabolitesSynovial cell sarcomaSame histological typeMalignant fibrous histiocytomaTotal prostaglandin synthesisHydroxyeicosatetraenoic acid synthesisHuman mesenchymal tumorsMesenchymal tumor cellsHistological typeMesenchymal tumorsPGF2 alphaFibrous histiocytomaThromboxane A2Embryonal carcinomaNude miceProstaglandin synthesisPGE2 synthesisTransplantable tumorsAlveolar rhabdomyosarcomaTumorsStromal cellsArachidonic acidNormal tissuesTumor cells
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