2023
Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study
Ding E, Deng F, Fang J, Li T, Hou M, Liu J, Miao K, Yan W, Fang K, Shi W, Fu Y, Liu Y, Dong H, Dong L, Ding C, Liu X, Pollitt K, Ji J, Shi Y, Cai Y, Tang S, Shi X. Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study. Environmental Health Perspectives 2023, 131: 047009. PMID: 37042841, PMCID: PMC10094192, DOI: 10.1289/ehp11896.Peer-Reviewed Original ResearchConceptsYears of ageOPE exposureAdults 60OPE metabolitesCommon endocrine-disrupting chemicalsChina BAPE studySubsequent key eventsType 2 diabetesExposure reduction strategiesAdverse outcome pathwaysDiabetogenic effectInsulin resistanceUrine metabolomeElevated riskEster exposureParticipants 60Endocrine-disrupting chemicalsBlood transcriptomeAdverse effectsGlycometabolic disordersBiological etiologyAgeT2DMulti-omics analysisMarkers
2022
Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19
Kosinsky Y, Peskov K, Stanski DR, Wetmore D, Vinetz J. Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19. Microbiology Spectrum 2022, 10: e02167-21. PMID: 35412356, PMCID: PMC9047529, DOI: 10.1128/spectrum.02167-21.Peer-Reviewed Original ResearchConceptsFOY-251SARS-CoV-2 cell entryCamostat mesylateInhibition of TMPRSS2Viral loadClinical trialsCOVID-19Viral entrySerine protease inhibitorSpike proteinCell entryMultiple clinical trialsPharmacokinetic-pharmacodynamic modelSARS-CoV-2 viral entryPK/PDSARS-CoV-2Protease inhibitorsOne-compartmentCell surface serine proteaseViral entry inhibitionTMPRSS2 inhibitionViral surface spike proteinsAcute exacerbationSemi-mechanistic pharmacokinetic-pharmacodynamic modelsSARS-CoV-2 coronavirus
2021
Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19 JACC State-of-the-Art Review
Talasaz AH, Sadeghipour P, Aghakouchakzadeh M, Dreyfus I, Kakavand H, Ariannejad H, Gupta A, Madhavan MV, Van Tassell BW, Jimenez D, Monreal M, Vaduganathan M, Fanikos J, Dixon DL, Piazza G, Parikh SA, Bhatt DL, Lip GYH, Stone GW, Krumholz HM, Libby P, Goldhaber SZ, Bikdeli B. Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19 JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2021, 78: 1635-1654. PMID: 34649702, PMCID: PMC8504484, DOI: 10.1016/j.jacc.2021.08.021.Peer-Reviewed Original ResearchConceptsLipid-modulating agentsEndothelial activationLow high-density lipoprotein cholesterolCOVID-19High-density lipoprotein cholesterolLipid modulating agentsHigh triglyceride levelsMultiorgan manifestationsStatin trialsLipoprotein cholesterolSystemic inflammationTriglyceride levelsJACC StateWorse outcomesInflammatory responsePatient managementRCTsCoronavirus diseaseViral entrySystematic searchLipid raft disruptionTrialsPatientsRaft disruptionPreventionExposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption
Hou M, Fang J, Shi Y, Tang S, Dong H, Liu Y, Deng F, Giesy JP, Godri Pollitt KJ, Cai Y, Shi X. Exposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption. Environment International 2021, 157: 106803. PMID: 34365320, DOI: 10.1016/j.envint.2021.106803.Peer-Reviewed Original ResearchConceptsElderly peopleHealth effectsWhole bloodFood frequency questionnaireHealthy elderly peopleHigh blood concentrationsBw/dayDaily total intakeAdverse health effectsHigher consumption frequencyTnBP exposureFrequency questionnaireIndoor dustPotential health effectsUrinary levelsBlood concentrationsDietary exposure pathwaysElderly populationOPE exposureExcretory capacityTotal intakeExposure pathwaysSuitable biomarkersBloodConsumption frequency
2019
Three-Component Coupling of Aldehydes, 2‑Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C–H Activation: Synthesis of Pyrido[1,2‑a]pyrimidin-4-ones
Hoang GL, Zoll AJ, Ellman JA. Three-Component Coupling of Aldehydes, 2‑Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C–H Activation: Synthesis of Pyrido[1,2‑a]pyrimidin-4-ones. Organic Letters 2019, 21: 3886-3890. PMID: 30896175, PMCID: PMC6561808, DOI: 10.1021/acs.orglett.9b00779.Peer-Reviewed Original Research
2018
Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications
Kauffman AC, Piotrowski-Daspit AS, Nakazawa KH, Jiang Y, Datye A, Saltzman WM. Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications. Biomacromolecules 2018, 19: 3861-3873. PMID: 30110158, PMCID: PMC6510397, DOI: 10.1021/acs.biomac.8b00997.Peer-Reviewed Original ResearchConceptsNucleic acid deliveryAcid deliveryLow charge density polymersBiomedical applicationsGene therapyEnzyme-Catalyzed PolymerizationEfficient delivery vehiclesCatalyzed polymerizationEfficient transfectionTerpolymer compositionUnique tunabilityPolymersViral vectorsDelivery vehiclesVivo applicationsPolycationic vectorsLow toxicityNucleic acidsCellular barriersTunabilitySpecific cell typesDNA plasmidsPolymerizationTerpolymerApplications
2017
Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats
Gao HT, Xu R, Cao WX, Qian LL, Wang M, Lu L, Xu Q, Yu SQ. Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food And Chemical Toxicology 2017, 101: 94-104. PMID: 28089693, DOI: 10.1016/j.fct.2017.01.011.Peer-Reviewed Original ResearchConceptsLong-term low-dose exposureMale reproductive toxicityLow-dose exposureReproductive toxicityMale rat reproductive systemSteroidogenic proteinsRat reproductive systemApoptosis-related proteinsPathological examinationRat testicular cellsMale ratsTesticular testosteroneCell cycle progressionRatsTesticular cellsReproductive systemTestosteroneToxicityExposureCycle progressionCell cycleIntegrated exposureButyl benzylToxicity evaluationMixP
2016
Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats
Gao HT, Xu R, Cao WX, Zhou X, Yan YH, Lu L, Xu Q, Shen Y. Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats. PLOS ONE 2016, 11: e0161253. PMID: 27575856, PMCID: PMC5004918, DOI: 10.1371/journal.pone.0161253.Peer-Reviewed Original ResearchConceptsInternal exposure levelsReproductive toxicityExposure levelsMale ratsTestosterone levelsFood emulsifier glycerin monostearatePAE exposureHistopathology of testesMale reproductive toxicityDEHP groupRat urineUbiquitous phthalate estersRatsPhthalate monoestersHistopathologyInjuryToxicityTestisGlycerin monostearatePrimary metabolitesExposureUPLC-MSFood additivesGavageLevels
2014
Diastereo- and Enantioselective Addition of Anilide-Functionalized Allenoates to N‑Acylimines Catalyzed by a Pyridylalanine-Based Peptide
Mbofana CT, Miller SJ. Diastereo- and Enantioselective Addition of Anilide-Functionalized Allenoates to N‑Acylimines Catalyzed by a Pyridylalanine-Based Peptide. Journal Of The American Chemical Society 2014, 136: 3285-3292. PMID: 24527787, DOI: 10.1021/ja412996f.Peer-Reviewed Original Research
2013
N‑Methylimidazole-catalyzed Synthesis of Carbamates from Hydroxamic Acids via the Lossen Rearrangement
Yoganathan S, Miller SJ. N‑Methylimidazole-catalyzed Synthesis of Carbamates from Hydroxamic Acids via the Lossen Rearrangement. Organic Letters 2013, 15: 602-605. PMID: 23327543, PMCID: PMC3563000, DOI: 10.1021/ol303424b.Peer-Reviewed Original Research
2011
An In Vivo Transfection Approach Elucidates a Role for Aedes aegypti Thioester-Containing Proteins in Flaviviral Infection
Cheng G, Liu L, Wang P, Zhang Y, Zhao YO, Colpitts TM, Feitosa F, Anderson JF, Fikrig E. An In Vivo Transfection Approach Elucidates a Role for Aedes aegypti Thioester-Containing Proteins in Flaviviral Infection. PLOS ONE 2011, 6: e22786. PMID: 21818390, PMCID: PMC3144946, DOI: 10.1371/journal.pone.0022786.Peer-Reviewed Original Research
2007
Straightforward Preparation and Assay of Aspartyl Protease Substrates with an Internal Thioester Linkage
Rosa‐Bauzá Y, Berst F, Ellman JA. Straightforward Preparation and Assay of Aspartyl Protease Substrates with an Internal Thioester Linkage. ChemBioChem 2007, 8: 981-984. PMID: 17492698, DOI: 10.1002/cbic.200700008.Peer-Reviewed Original Research
2005
Catalytic Enantioselective Sulfinyl Transfer Using Cinchona Alkaloid Catalysts
Peltier HM, Evans JW, Ellman JA. Catalytic Enantioselective Sulfinyl Transfer Using Cinchona Alkaloid Catalysts. Organic Letters 2005, 7: 1733-1736. PMID: 15844893, DOI: 10.1021/ol050275p.Peer-Reviewed Original ResearchConceptsCinchona alkaloid catalystsCatalytic Enantioselective SynthesisPractical reaction conditionsAvailable cinchona alkaloidsSuperior catalystTransfer reactionsReaction conditionsSulfinate estersEnantioselective synthesisCinchona alkaloidsBenzyl alcoholEster productsCatalystAlcoholSynthesisTransferReactionChlorideEstersEEAlkaloidsYieldProducts
2003
Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27 kip1 Down-regulation and bcl-xL Induction, and Is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity*
Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27 kip1 Down-regulation and bcl-xL Induction, and Is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity*. Journal Of Biological Chemistry 2003, 279: 910-919. PMID: 14573608, DOI: 10.1074/jbc.m209733200.Peer-Reviewed Original ResearchMeSH KeywordsAnnexin A5Antibiotics, Antineoplasticbcl-X ProteinCD28 AntigensCD3 ComplexCD8-Positive T-LymphocytesCell Cycle ProteinsCell DivisionColoring AgentsCyclin DCyclin-Dependent Kinase Inhibitor p27CyclinsDose-Response Relationship, DrugDown-RegulationEnzyme InhibitorsEstersFluoresceinsHumansKineticsLymphocytesPhosphatidylinositol 3-KinasesProtein BindingProto-Oncogene Proteins c-bcl-2Signal TransductionSirolimusT-LymphocytesTime FactorsTumor Suppressor ProteinsConceptsInhibitor of phosphoinositideT cell receptorMammalian cell typesCell receptorBcl-xL inductionAction of rapamycinBcl-xL expressionT cellsHuman cellsCell survivalP27 Kip1Resistant proliferationCell typesPhosphoinositideHuman CD8RapamycinCellular proliferationEffect of rapamycinMicrobial infectionsCell populationsHigh-affinity T-cell receptorsSelective immunosuppressive effectT Cells CorrelateT cell populationsProliferationSynthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens
Labaree DC, Zhang JX, Harris HA, O'Connor C, Reynolds TY, Hochberg RB. Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2003, 46: 1886-1904. PMID: 12723952, DOI: 10.1021/jm0204340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveEsterasesEstersEstradiolEstradiol CongenersEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansIn Vitro TechniquesKidneyLigandsMiceMicrosomesOrgan SizeOxidoreductasesRatsRats, Sprague-DawleyReceptors, EstrogenStructure-Activity RelationshipTumor Cells, CulturedUterusVaginaConceptsEstrogen receptorHormonal activityReceptor bindingAnalogues of estradiolEstrogen-sensitive genesEstrogen receptor bindingEstrogen-responsive genesEstrogenic actionIshikawa cellsEffective estrogenActive estrogensEstrogenHormonal actionDerivatives of estradiolEstradiolEstrogenic responsesSystemic actionReceptorsEstrogenic activityVivo assaysNonspecific esterasesSteroid nucleusSensitive genesActivitySteroid ring
2001
Estradiol-16α-carboxylic Acid Esters as Locally Active Estrogens
Labaree D, Reynolds T, Hochberg R. Estradiol-16α-carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2001, 44: 1802-1814. PMID: 11356114, DOI: 10.1021/jm000523h.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsBinding, CompetitiveEnzyme InductionEstersEstradiolEstradiol CongenersEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansIn Vitro TechniquesMiceMicrosomes, LiverOrgan SizeOvariectomyOxidoreductasesRatsRats, Sprague-DawleyReceptors, EstrogenStructure-Activity RelationshipTumor Cells, CulturedUterusVaginaConceptsEstrogenic actionActive estrogensAnalogues of estradiolRat uterine weightEstrogenic potencyEstrogen receptor bindingSystemic estrogenRat hepatic microsomesUterine weightIshikawa cellsVivo modelEstrogenTherapeutic treatmentHepatic microsomesReceptor bindingFluoroethyl esterSystemic actionER affinityHigh ER affinityEstradiolEsterase hydrolysisPotencyDyspareuniaLocal actionMenopause
1995
Long-lived testosterone esters in the rat.
Borg W, Shackleton CH, Pahuja SL, Hochberg RB. Long-lived testosterone esters in the rat. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 1545-1549. PMID: 7878017, PMCID: PMC42556, DOI: 10.1073/pnas.92.5.1545.Peer-Reviewed Original ResearchConceptsTestosterone estersPresence of testosteronePotent therapeutic agentLong-term castratesFemale ratsMale ratsTestosterone levelsMeasurable fallEster fractionIntact malesSteroid hormonesTherapeutic agentsRatsHormonal potencyTarget tissuesImportant physiological impactAndrogensFatTestosteroneMost tissuesCastrationTissueFatty acidsTestosterone equivalentsPhysiological impact
1987
Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake
Carpenter T, Pettifor J, Russell R, Pitha J, Mobarhan S, Ossip M, Wainer S, Anast C. Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake. The Journal Of Pediatrics 1987, 111: 507-512. PMID: 3655980, DOI: 10.1016/s0022-3476(87)80109-9.Peer-Reviewed Original ResearchConceptsSimilar clinical featuresRetinyl ester levelsRetinol intakeTherapeutic trialsClinical featuresHypervitaminosis ADietary vitaminLiver spreadVitamin AMicrograms/Total vitaminInfusionRetinyl estersSame dietIntakeEventual deathVitaminEster levelsYounger brotherAgent 2SyndromeSymptomsYearsExcretionIntoxication
1973
Covalent attachment of fluorescent groups to the 5′-end of transfer RNA
Yang C, Söll D. Covalent attachment of fluorescent groups to the 5′-end of transfer RNA. Archives Of Biochemistry And Biophysics 1973, 155: 70-81. PMID: 4351348, DOI: 10.1016/s0003-9861(73)80010-4.Peer-Reviewed Original Research
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