2020
Pathophysiological effects of androgens on the female vascular system
Stone T, Stachenfeld NS. Pathophysiological effects of androgens on the female vascular system. Biology Of Sex Differences 2020, 11: 45. PMID: 32727622, PMCID: PMC7391603, DOI: 10.1186/s13293-020-00323-6.ChaptersConceptsFemale cardiovascular systemPolycystic ovary syndromeFemale vasculatureHormone therapyOvary syndromePathophysiological effectsCardiovascular systemTransgender menPrimary medical interventionSignificant medical risksHigh blood pressureCardiovascular disease statesEffects of testosteroneEndogenous androgen concentrationsSex differencesPotential causative linkChronic hyperandrogenismTestosterone dosesEndothelial dysfunctionBlood pressurePatient groupVascular functionCardiovascular regulationSex hormonesAndrogen receptor
2013
Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol
Wenner MM, Haddadin A, Taylor HS, Stachenfeld NS. Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. The Journal Of Physiology 2013, 591: 2345-2355. PMID: 23401618, PMCID: PMC3650699, DOI: 10.1113/jphysiol.2012.247882.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceE2 administrationOrthostatic toleranceVascular resistanceBlood pressureStroke volumeHeart rateGonadotrophin-releasing hormone antagonistLevels of LBNPLower central volumeReproductive hormone productionAdministration of E2Peripheral vascular resistanceBeat blood pressureAutonomic cardiovascular regulationLower stroke volumeLower body negative pressure testHeart rate responseInfluence of oestradiolBaroreflex controlTolerant womenHormone antagonistCardiovascular regulationPeripheral vasoconstrictionAutonomic control
2008
Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure
Vadigepalli R, Nikolaev E, Miller G, Ogunnaike B, Gonye G, Kholodenko B, Schwaber J. Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure. The FASEB Journal 2008, 22: 756.2-756.2. DOI: 10.1096/fasebj.22.1_supplement.756.2.Peer-Reviewed Original ResearchRelease of norepinephrineAngiotensin II receptorsSynthesis of norepinephrineType 1 activationAP-1PI3K pathwayCardiorespiratory neuronsBlood pressureAngiotensin IIC-Jun activationCardiovascular regulationCNS neuronsLong-term effectsCentral regulationTyrosine hydroxylaseTranscription factor AP-1Rate-limiting enzymeII receptorsKey neurotransmitterNeuronal adaptationFactor AP-1NorepinephrineK pathwayC-fos
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