2024
CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum
Choi J, Acharya R, Lim H, Lee K, Seo J, Yang E, Kim H, Yoon J, Chang D, Kim S, Kim S, Birnbaumer L, Suh-Kim H. CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2409773121. PMID: 39602265, PMCID: PMC11626142, DOI: 10.1073/pnas.2409773121.Peer-Reviewed Original ResearchConceptsDepolarization-induced suppression of excitationCannabinoid receptor type 1Synaptic plasticityDepolarization-induced suppressionSuppression of excitationHeterotrimeric Go proteinAbundant G proteinGi/o-coupled receptorsNeurotransmitter releasePresynaptic terminalsReceptor type 1Regulate neurotransmitter releaseBeam balance testBrain synaptosomal fractionsRegulating neurotransmittersMutated animalsMultiple proteinsKO miceProteomic analysisMotor deficitsCB1RCerebellumEpileptic encephalopathyGo proteinsSignaling pathway
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide
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