2025
Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis
Friligkou E, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Polimanti R. Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis. Psychological Medicine 2025, 55: e145. PMID: 40357923, PMCID: PMC12094657, DOI: 10.1017/s0033291725001217.Peer-Reviewed Original ResearchConceptsBipolar disorderPleiotropic lociCross-disorder meta-analysisGenome-wide association datasetGenome-wide analysisGenome-wide significanceTissue enrichment analysisBrain transcriptomic dataBrain transcriptome profilesPsychiatric Genomics ConsortiumCadherin signalingGenome-wideGenetic architectureGene discoveryDiagnostic boundariesPleiotropic variantsFrontal cortexReceptor-mediated signalingTranscriptome dataSchizophreniaGenetic mechanismsGenomics ConsortiumTranscriptome profilingAssociation datasetEnrichment analysis
2023
Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report
Christian N, Butner J, Evarts M, Weimer M. Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report. Journal Of Addiction Medicine 2023, 17: 488-490. PMID: 37579118, DOI: 10.1097/adm.0000000000001151.Peer-Reviewed Case Reports and Technical NotesConceptsClinical Opiate Withdrawal Scale (COWS) scoresOpioid use disorderKetamine infusionOpioid withdrawalCase reportUse disordersScale scoreSevere opioid use disorderFull opioid agonistsHours of admissionEmergency department settingFirst case reportInpatient hospital settingLife-saving medicationsReceptor-mediated signalingLack of evidenceMale patientsFentanyl useOpioid agonistsEmergency departmentComplete resolutionDepartment settingClinical dilemmaAppropriate treatmentHospital setting
2022
Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector
Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2022, 11: e77794. PMID: 35179491, PMCID: PMC8856650, DOI: 10.7554/elife.77794.Peer-Reviewed Original ResearchReceptor-mediated signalingArthropod vectors
2021
The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector
Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector. ELife 2021, 10: e72568. PMID: 34783654, PMCID: PMC8639152, DOI: 10.7554/elife.72568.Peer-Reviewed Original ResearchConceptsReceptor-mediated signalingAdiponectin receptorsAdiponectinLyme disease agentLyme disease spirochetePhospholipid metabolismPhosphatidylserine synthase ITick gutReceptor-like proteinMammalian homeostasisArthropod vectorsDisease agentsRNAi assaysRNA interferenceAlternative pathwaySynthase IPathwayMetabolic pathwaysTicksInfection
2013
Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ. Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway. Nature Communications 2013, 4: 2909. PMID: 24352507, PMCID: PMC3895487, DOI: 10.1038/ncomms3909.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAdenosine TriphosphateAnimalsCarrier ProteinsCyclic AMPCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesHypoxia-Inducible Factor 1, alpha SubunitInflammasomesInterleukin-1betaLipopolysaccharidesLiverMacrophagesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinReceptor, Adenosine A2ASignal TransductionConceptsHIF-1α pathwayInflammasome activityInflammasome activationA2A receptorsIL-1β productionIL-1β responseReceptor-mediated signalingLack of responseTolerogenic stateChronic diseasesInflammatory responseInflammasome pathwayPrevious exposureLipopolysaccharideAdenosineReceptorsActivationKey regulatorInitial activationPathwaySignalingResponseInterleukinStimuliDiseaseDeficiency Of JAGN1 Causes Severe Congenital Neutropenia Associated With Defective Secretory Pathway and Aberrant Myeloid Cell Homeostasis
Boztug K, Järvinen P, Salzer E, Racek T, Mönch S, Garncarz W, Gertz E, Schäffer A, Antonopoulos A, Haslam S, Ziesenitz L, Puchalka J, Diestelhorst J, Appaswamy G, Lescoeur B, Giambruno R, Bigenzahn J, Elling U, Pfeifer D, Welte K, Brandes G, Sherkat R, Van der Werff Ten Bosch J, Rezaei N, Etzioni A, Bellanne-Chantelot C, Superti-Furga G, Bennett K, von Blume J, Dell A, Donadieu J, Klein C. Deficiency Of JAGN1 Causes Severe Congenital Neutropenia Associated With Defective Secretory Pathway and Aberrant Myeloid Cell Homeostasis. Blood 2013, 122: 439. DOI: 10.1182/blood.v122.21.439.439.Peer-Reviewed Original ResearchSevere congenital neutropeniaSCN patientsAnalysis of patientsMyeloid cell homeostasisHomolog 1Survival of neutrophilsDistinct homozygous mutationsHomozygous mutation c.Receptor-mediated signalingOnly consistent findingNeutropenia AssociatedNeutrophil granulocytesPatientsCongenital neutropeniaComplete refractorinessClinical phenotypeNeutrophilsMature neutrophilsDevelopmental delayMarked reductionBiallelic mutationsAdditional studiesSkeletal abnormalitiesConsistent findingHomozygous mutation
2012
Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood.
Qian F, Montgomery RR. Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood. Journal Of Visualized Experiments 2012 PMID: 22525943, PMCID: PMC3466655, DOI: 10.3791/3741.Peer-Reviewed Original ResearchConceptsToll-like receptorsDendritic cellsImmune responseToll-like receptor-mediated signalingCell-mediated immune responsesCertain Toll-like receptorsAntigen-presenting cellsPeripheral blood monocytesHealthy human donorsNF-κB pathwayInnate immune systemReceptor-mediated signalingQuantitative flow cytometryTLR levelsWest Nile virusPatient susceptibilityUnderstanding of immunosenescenceImmune responsivenessElderly donorsLarge cohortOlder donorsAdaptive immunityBlood monocytesNF-κBTherapeutic interventions
2011
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis
Du Y, Chou C, Klimstra D, Varmus H. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16753-16758. PMID: 21940500, PMCID: PMC3189086, DOI: 10.1073/pnas.1114022108.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Islet CellAnimalsBlotting, WesternEnzyme-Linked Immunosorbent AssayErbB ReceptorsExtracellular Matrix ProteinsGene Transfer TechniquesHyaluronan ReceptorsImmunohistochemistryImmunoprecipitationLiver NeoplasmsMiceMitogen-Activated Protein Kinase 3PhosphorylationReverse Transcriptase Polymerase Chain ReactionSignal TransductionSTAT3 Transcription FactorConceptsEpidermal growth factor receptorGrowth factor receptor-mediated signalingPhosphorylation of epidermal growth factor receptorSusceptibility to apoptosisIncreased cell migrationHyaluronan-mediated motilityInduced phosphorylation of epidermal growth factor receptorReceptor-mediated signalingTail veins of immunodeficient miceExperimental metastasis assayInduced phosphorylationMouse modelEpidermal growth factor receptor inhibitorsMetastasis to lymph nodesCell migrationSignaling pathwayIsoform BHuman cancersCell tumorigenesisGene transferSomatic gene transferMetastasis assaysPromote tumor growthGrowth factor receptorRHAMM
2008
Nanobiotechnology and Cell Biology: Micro- and Nanofabricated Surfaces to Investigate Receptor-Mediated Signaling
Torres AJ, Wu M, Holowka D, Baird B. Nanobiotechnology and Cell Biology: Micro- and Nanofabricated Surfaces to Investigate Receptor-Mediated Signaling. Annual Review Of Biophysics 2008, 37: 265-288. PMID: 18573082, DOI: 10.1146/annurev.biophys.36.040306.132651.Peer-Reviewed Original ResearchConceptsCell biologySpatial regulationReceptor-mediated signalingCellular processesChemical modification schemesCellular interactionsFluorescence microscopyBiologySignalingCellsRegulationFundamental mechanismsReceptor systemImmune cellsNew informationEngineering toolsReceptorsPhysical environmentNew opportunities
2003
Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
Nichols KE, Haines K, Myung PS, Newbrough S, Myers E, Jumaa H, Shedlock DJ, Shen H, Koretzky GA. Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors. Journal Of Leukocyte Biology 2003, 75: 541-552. PMID: 14694181, DOI: 10.1189/jlb.0703312.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesSLP-76SLP-65Extracellular signaling-regulated kinase 1Sheep red blood cellsInitial host defenseLow-dose infectionNumber of liverWild-type miceSrc homology 2Functional eventsMarrow-derived macrophagesTotal body burdenReceptor-mediated signalingReceptor-induced activationRed blood cellsLeukocyte-specific phosphoproteinReactive oxygen intermediatesT lymphocytesMast cellsFc receptorsMacrophage activationListeria monocytogenesHost defenseColony-forming units
1998
Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement
Wang G, Collinge M, Blasi F, Pardi R, Bender J. Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6296-6301. PMID: 9600959, PMCID: PMC27663, DOI: 10.1073/pnas.95.11.6296.Peer-Reviewed Original ResearchConceptsAU-rich elementsLFA-1 activationMRNA degradationReporter constructsUrokinase plasminogen activator receptorT cell activationCrucial cis-acting elementsCis-acting elementsLymphocyte function-associated antigen-1Integrin lymphocyte function-associated antigen-1Jurkat T cellsLFA-1 engagementUPAR cDNAReceptor-mediated signalingPosttranscriptional regulationTransmembrane signalingReporter mRNAIntegrin engagementCell activationInhibitor 5Adhesion receptorsSecond messengerMessenger RNA levelsPlasminogen activator receptorFunction-associated antigen-1
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