2022
Direct tracking of reverse-transcriptase speed and template sensitivity: implications for sequencing and analysis of long RNA molecules
Guo LT, Olson S, Patel S, Graveley BR, Pyle AM. Direct tracking of reverse-transcriptase speed and template sensitivity: implications for sequencing and analysis of long RNA molecules. Nucleic Acids Research 2022, 50: 6980-6989. PMID: 35713547, PMCID: PMC9262592, DOI: 10.1093/nar/gkac518.Peer-Reviewed Original Research
2020
Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics
Peccia J, Zulli A, Brackney DE, Grubaugh ND, Kaplan EH, Casanovas-Massana A, Ko AI, Malik AA, Wang D, Wang M, Warren JL, Weinberger DM, Arnold W, Omer SB. Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics. Nature Biotechnology 2020, 38: 1164-1167. PMID: 32948856, PMCID: PMC8325066, DOI: 10.1038/s41587-020-0684-z.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 positive test resultsSARS-CoV-2 RNAPositive test resultsHospital admissionSpecimen collectionCOVID-19 hospital admissionsLocal hospital admissionsSARS-CoV-2 RNA concentrationsCoronavirus disease 2019 (COVID-19) outbreakRNA concentrationDisease 2019 outbreakClinical test resultsInfection surveillanceInfection dynamicsPositive testPopulation-wide levelCommunity infection dynamicsAdmissionNew Haven
2019
Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development
Kaffman A, White JD, Wei L, Johnson FK, Krystal JH. Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development. Methods In Molecular Biology 2019, 2011: 3-22. PMID: 31273690, PMCID: PMC6895673, DOI: 10.1007/978-1-4939-9554-7_1.Peer-Reviewed Original ResearchConceptsPreclinical researchAnimal modelsPsychiatric conditionsLower clinical success ratesClinical success rateCommon psychiatric conditionsPsychiatric clinical trialsClinical trialsNew pharmacotherapiesMore effective interventionsPreclinical workPsychiatric disordersPsychiatric pathophysiologyMental illnessSystematic reviewEffective interventionsAnimal experimentsDrug development processSuccess rateDrug developmentHuman psychopathologyPharmaceutical companiesPredictive validityLarge pharmaceutical companiesAnimals
2018
Secure genome-wide association analysis using multiparty computation
Cho H, Wu D, Berger B. Secure genome-wide association analysis using multiparty computation. Nature Biotechnology 2018, 36: 547-551. PMID: 29734293, PMCID: PMC5990440, DOI: 10.1038/nbt.4108.Peer-Reviewed Original Research
2014
Human Neuroimaging and the BRAIN Initiative: A Joint Statement from the ASNR and ASFNR, with the support of the RSNA, ACR, ARR, and ISMRM
Sze G, Wintermark M, Law M, Mukherjee P, Hess C. Human Neuroimaging and the BRAIN Initiative: A Joint Statement from the ASNR and ASFNR, with the support of the RSNA, ACR, ARR, and ISMRM. American Journal Of Neuroradiology 2014, 35: 213-214. PMID: 24436343, PMCID: PMC7965740, DOI: 10.3174/ajnr.a3874.Peer-Reviewed Original Research
2013
Exterior design: strategies for redecorating the bacterial surface with small molecules
Gautam S, Gniadek TJ, Kim T, Spiegel DA. Exterior design: strategies for redecorating the bacterial surface with small molecules. Trends In Biotechnology 2013, 31: 258-267. PMID: 23490213, PMCID: PMC3641905, DOI: 10.1016/j.tibtech.2013.01.012.BooksConceptsExciting new setField of biotechnologySurface displayBacterial surface displayBacterial platformSmall moleculesUnique propertiesSurface of bacteriaHeterologous proteinsSynthetic materialsGreat potentialRecombinant techniquesBacterial surfaceSuch technologiesSurfaceBiocatalysisNovel methodBiomedicineBiotechnologyBasic bacteriologyCompoundsMoleculesPlatformTechnologyProperties
2012
Southern California: A Hotbed of Biomedical Engineering: Nine Bioengineers Describe Their Research and Why Southern California Has the Biotech Market Cornered
Berger T, Meng E, George S, Khoo M, Marmarelis V, McCulloch A, Cauwenberghs G, Ohno-Machado L, Schultz J, Johnson J. Southern California: A Hotbed of Biomedical Engineering: Nine Bioengineers Describe Their Research and Why Southern California Has the Biotech Market Cornered. IEEE Pulse 2012, 3: 14-21. PMID: 23008840, DOI: 10.1109/mpul.2012.2197698.Peer-Reviewed Original Research
2010
Antibody validation
Bordeaux J, Welsh A, Agarwal S, Killiam E, Baquero M, Hanna J, Anagnostou V, Rimm D. Antibody validation. BioTechniques 2010, 48: 197-209. PMID: 20359301, PMCID: PMC3891910, DOI: 10.2144/000113382.Peer-Reviewed Original Research
2009
Programming cells by multiplex genome engineering and accelerated evolution
Wang HH, Isaacs FJ, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM. Programming cells by multiplex genome engineering and accelerated evolution. Nature 2009, 460: 894-898. PMID: 19633652, PMCID: PMC4590770, DOI: 10.1038/nature08187.Peer-Reviewed Original ResearchPeakSeq enables systematic scoring of ChIP-seq experiments relative to controls
Rozowsky J, Euskirchen G, Auerbach RK, Zhang ZD, Gibson T, Bjornson R, Carriero N, Snyder M, Gerstein MB. PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls. Nature Biotechnology 2009, 27: 66-75. PMID: 19122651, PMCID: PMC2924752, DOI: 10.1038/nbt.1518.Peer-Reviewed Original Research
2008
Prevalence of productivity-enhancing technologies in radiology.
Nayak NR, Meghea C, Bhargavan M, Forman HP, Sunshine JH. Prevalence of productivity-enhancing technologies in radiology. American Journal Of Roentgenology 2008, 190: 1445-52. PMID: 18492890, DOI: 10.2214/ajr.07.3501.Peer-Reviewed Original ResearchNanobiotechnology and Cell Biology: Micro- and Nanofabricated Surfaces to Investigate Receptor-Mediated Signaling
Torres AJ, Wu M, Holowka D, Baird B. Nanobiotechnology and Cell Biology: Micro- and Nanofabricated Surfaces to Investigate Receptor-Mediated Signaling. Annual Review Of Biophysics 2008, 37: 265-288. PMID: 18573082, DOI: 10.1146/annurev.biophys.36.040306.132651.Peer-Reviewed Original ResearchConceptsCell biologySpatial regulationReceptor-mediated signalingCellular processesChemical modification schemesCellular interactionsFluorescence microscopyBiologySignalingCellsRegulationFundamental mechanismsReceptor systemImmune cellsNew informationEngineering toolsReceptorsPhysical environmentNew opportunities
2007
Keck Foundation Biotechnology Resource Laboratory, Yale University.
Stone KL, Bjornson RD, Blasko GG, Bruce C, Cofrancesco R, Carriero NJ, Colangelo CM, Crawford JK, Crawford JM, daSilva NC, Deluca JD, Elliott JI, Elliott MM, Flory PJ, Folta-Stogniew EJ, Gulcicek E, Kong Y, Lam TT, Lee JY, Lin A, LoPresti MB, Mane SM, McMurray WJ, Tikhonova IR, Westman S, Williams NA, Wu TL, Hongyu Z, Williams KR. Keck Foundation Biotechnology Resource Laboratory, Yale University. The Yale Journal Of Biology And Medicine 2007, 80: 195-211. PMID: 18449392, PMCID: PMC2347368.Peer-Reviewed Original Research
2005
Proteomics and the Analysis of Proteomic Data: An Overview of Current Protein‐Profiling Technologies
Gulcicek EE, Colangelo CM, McMurray W, Stone K, Williams K, Wu T, Zhao H, Spratt H, Kurosky A, Wu B. Proteomics and the Analysis of Proteomic Data: An Overview of Current Protein‐Profiling Technologies. Current Protocols In Bioinformatics 2005, 10: 13.1.1-13.1.31. PMID: 18428746, PMCID: PMC3863626, DOI: 10.1002/0471250953.bi1301s10.Peer-Reviewed Original ResearchConceptsProtein/peptide chemistryHundreds of proteinsProtein profiling technologiesPeptide chemistryBioanalytical chemistryProteomic methodologiesChromatographic separationProteomic dataMass spectrometryCellular biologyBiological fluidsCell typesChemistryRelative levelsDiverse scientific disciplinesProteomicsSpectrometryBiologyBioinformaticsProteinSeparationExpressionGiant vesicles formed by gentle hydration and electroformation: A comparison by fluorescence microscopy
Rodriguez N, Pincet F, Cribier S. Giant vesicles formed by gentle hydration and electroformation: A comparison by fluorescence microscopy. Colloids And Surfaces B Biointerfaces 2005, 42: 125-130. PMID: 15833663, DOI: 10.1016/j.colsurfb.2005.01.010.Peer-Reviewed Original Research
2003
Tinker, Tailor: Can Venter Stitch Together a Genome From Scratch?
Zimmer C. Tinker, Tailor: Can Venter Stitch Together a Genome From Scratch? Science 2003, 299: 1006-1007. PMID: 12586921, DOI: 10.1126/science.299.5609.1006.Publications for non-academic audiences
2002
Deoxyribozymes: new activities and new applications
Emilsson G, Breaker R. Deoxyribozymes: new activities and new applications. Cellular And Molecular Life Sciences 2002, 59: 596-607. PMID: 12022469, PMCID: PMC11337523, DOI: 10.1007/s00018-002-8452-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBiotechnologyDNADNA, CatalyticGenomeKineticsMetalsModels, GeneticMolecular Sequence DataRNA
1998
Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
Brüstle O, Choudhary K, Karram K, Hüttner A, Murray K, Dubois-Dalcq M, McKay R. Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats. Nature Biotechnology 1998, 16: 1040-1044. PMID: 9831032, DOI: 10.1038/3481.Peer-Reviewed Original ResearchConceptsFetal human brain cellsCentral nervous systemHuman brain cellsBrain cellsNervous systemEmbryonic ratsNeural cell migrationIntraventricular transplantationCerebral ventricleNeural chimerasFunctional nervous systemChimeric brainsHuman neural developmentNeural developmentRatsCell migrationBrainCellsRodent cellsUnique modelHuman cellsTransplantationAstrocytesVentricleChimerismMetabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes
Kholodenko B, Cascante M, Hoek J, Westerhoff H, Schwaber J. Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes. Biotechnology And Bioengineering 1998, 59: 239-247. PMID: 10099334, DOI: 10.1002/(sici)1097-0290(19980720)59:2<239::aid-bit11>3.0.co;2-9.Peer-Reviewed Original Research
1997
Editorial: A New Releasing Factor? with Biotechnology and a Little Bit of Luck
Dannies P. Editorial: A New Releasing Factor? with Biotechnology and a Little Bit of Luck. Endocrinology 1997, 138: 5085-5086. PMID: 9389485, DOI: 10.1210/endo.138.12.5710.Peer-Reviewed Original Research
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