2011
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis
Du Y, Chou C, Klimstra D, Varmus H. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16753-16758. PMID: 21940500, PMCID: PMC3189086, DOI: 10.1073/pnas.1114022108.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Islet CellAnimalsBlotting, WesternEnzyme-Linked Immunosorbent AssayErbB ReceptorsExtracellular Matrix ProteinsGene Transfer TechniquesHyaluronan ReceptorsImmunohistochemistryImmunoprecipitationLiver NeoplasmsMiceMitogen-Activated Protein Kinase 3PhosphorylationReverse Transcriptase Polymerase Chain ReactionSignal TransductionSTAT3 Transcription FactorConceptsEpidermal growth factor receptorGrowth factor receptor-mediated signalingPhosphorylation of epidermal growth factor receptorSusceptibility to apoptosisIncreased cell migrationHyaluronan-mediated motilityInduced phosphorylation of epidermal growth factor receptorReceptor-mediated signalingTail veins of immunodeficient miceExperimental metastasis assayInduced phosphorylationMouse modelEpidermal growth factor receptor inhibitorsMetastasis to lymph nodesCell migrationSignaling pathwayIsoform BHuman cancersCell tumorigenesisGene transferSomatic gene transferMetastasis assaysPromote tumor growthGrowth factor receptorRHAMM
2007
CCR2 identifies first responders among human CD4+ memory T cells: long-lived, apoptosis-resistant, antigen-responsive cells with enhanced migration potential, a low threshold for activation, and immediate effector capabilities (85.5)
Farber J, Song K, Zhang H, Rabin R, Hill B, Sereti I, Prussin C, Siegel R, Douek D, Roederer M. CCR2 identifies first responders among human CD4+ memory T cells: long-lived, apoptosis-resistant, antigen-responsive cells with enhanced migration potential, a low threshold for activation, and immediate effector capabilities (85.5). The Journal Of Immunology 2007, 178: s119-s119. DOI: 10.4049/jimmunol.178.supp.85.5.Peer-Reviewed Original ResearchMemory T cellsT cellsEffector capabilitiesExpression of chemokine receptors CCR5Memory CD4+ T cellsCD4+ memory T cellsCD4+ T cellsLong-lived memory cellsHuman memory CD4+ T cellsCCR2+ cellsCD4+ subsetHuman CD4+ memory T cellsChemokine receptor CCR5Antigen-responsive cellsChemokine receptor typeResistance to apoptosisSecrete high levelsCells co-expressingSusceptibility to apoptosisReduced proliferative potentialEffector cytokinesExcision circlesEnhanced migration potentialReceptor CCR5Peripheral blood
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