2013
Grading of Well-differentiated Pancreatic Neuroendocrine Tumors Is Improved by the Inclusion of Both Ki67 Proliferative Index and Mitotic Rate
McCall C, Shi C, Cornish T, Klimstra D, Tang L, Basturk O, Mun L, Ellison T, Wolfgang C, Choti M, Schulick R, Edil B, Hruban R. Grading of Well-differentiated Pancreatic Neuroendocrine Tumors Is Improved by the Inclusion of Both Ki67 Proliferative Index and Mitotic Rate. The American Journal Of Surgical Pathology 2013, 37: 1671-1677. PMID: 24121170, PMCID: PMC3891823, DOI: 10.1097/pas.0000000000000089.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBiopsyCell DifferentiationCell ProliferationFemaleHumansImmunohistochemistryKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMitotic IndexNeoplasm GradingNeoplasm InvasivenessNeuroendocrine TumorsPancreatic NeoplasmsPredictive Value of TestsPrognosisProportional Hazards ModelsYoung AdultConceptsGrade 1 tumorsKi67 proliferative indexPancreatic neuroendocrine tumorsOverall survivalProliferative indexMitotic rateMitotic gradeWorld Health OrganizationNeuroendocrine tumorsHistological featuresWell-differentiated pancreatic neuroendocrine tumorsWorld Health Organization grade 2Grade 2Metastasis to lymph nodesGrade 1Grading of PanNETAggressive histological featuresSmall vessel invasionInfiltrative growth patternShorter overall survivalDigital image analysis softwareKi67 gradeKi67/MIB-1Median survivalPerineural invasion
2011
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis
Du Y, Chou C, Klimstra D, Varmus H. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16753-16758. PMID: 21940500, PMCID: PMC3189086, DOI: 10.1073/pnas.1114022108.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Islet CellAnimalsBlotting, WesternEnzyme-Linked Immunosorbent AssayErbB ReceptorsExtracellular Matrix ProteinsGene Transfer TechniquesHyaluronan ReceptorsImmunohistochemistryImmunoprecipitationLiver NeoplasmsMiceMitogen-Activated Protein Kinase 3PhosphorylationReverse Transcriptase Polymerase Chain ReactionSignal TransductionSTAT3 Transcription FactorConceptsEpidermal growth factor receptorGrowth factor receptor-mediated signalingPhosphorylation of epidermal growth factor receptorSusceptibility to apoptosisIncreased cell migrationHyaluronan-mediated motilityInduced phosphorylation of epidermal growth factor receptorReceptor-mediated signalingTail veins of immunodeficient miceExperimental metastasis assayInduced phosphorylationMouse modelEpidermal growth factor receptor inhibitorsMetastasis to lymph nodesCell migrationSignaling pathwayIsoform BHuman cancersCell tumorigenesisGene transferSomatic gene transferMetastasis assaysPromote tumor growthGrowth factor receptorRHAMM
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