Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis
Du Y, Chou C, Klimstra D, Varmus H. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16753-16758. PMID: 21940500, PMCID: PMC3189086, DOI: 10.1073/pnas.1114022108.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Islet CellAnimalsBlotting, WesternEnzyme-Linked Immunosorbent AssayErbB ReceptorsExtracellular Matrix ProteinsGene Transfer TechniquesHyaluronan ReceptorsImmunohistochemistryImmunoprecipitationLiver NeoplasmsMiceMitogen-Activated Protein Kinase 3PhosphorylationReverse Transcriptase Polymerase Chain ReactionSignal TransductionSTAT3 Transcription FactorConceptsEpidermal growth factor receptorGrowth factor receptor-mediated signalingPhosphorylation of epidermal growth factor receptorSusceptibility to apoptosisIncreased cell migrationHyaluronan-mediated motilityInduced phosphorylation of epidermal growth factor receptorReceptor-mediated signalingTail veins of immunodeficient miceExperimental metastasis assayInduced phosphorylationMouse modelEpidermal growth factor receptor inhibitorsMetastasis to lymph nodesCell migrationSignaling pathwayIsoform BHuman cancersCell tumorigenesisGene transferSomatic gene transferMetastasis assaysPromote tumor growthGrowth factor receptorRHAMM
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