2025
Pancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition
Lulji Taraqaz B, Hsu Y, Tsai P, Li Y, Chen F, Yang W, Shen M. Pancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition. Biomedicine & Pharmacotherapy 2025, 187: 118066. PMID: 40262236, DOI: 10.1016/j.biopha.2025.118066.Peer-Reviewed Original ResearchConceptsB cell apoptosisRat pancreatic B-cellsLow-density lipoproteinPathway analysisSignaling pathwayOxidative stressApoptosisImproved cell viabilityRIN-m5FB cellsLectin-like oxidized low-density lipoprotein receptor-1Pancreatic B-cellsHigh-fat dietCell viabilityInsulin toleranceAntiapoptotic propertiesKansuinine AMitigated apoptosisMechanism of actionMolecular dockingStress inhibitionPathwayLow-density lipoprotein receptor-1Improved glucoseHigh-fat
2024
Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes
Germanos M, Yau B, Taper M, Yeoman C, Wilson A, An Y, Cattin-Ortolá J, Masler D, Tong J, Naghiloo S, Needham E, van der Kraan A, Sun K, Loudovaris T, Diaz-Vegas A, Larance M, Thomas H, von Blume J, Thorn P, Ailion M, Asensio C, Kebede M. Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes. IScience 2024, 28: 111719. PMID: 39898024, PMCID: PMC11787600, DOI: 10.1016/j.isci.2024.111719.Peer-Reviewed Original ResearchInsulin granule biogenesisGranule biogenesisSecretory granule biogenesisSpecialized secretory cellsInsulin secretory pathwaySecretory pathwayHuman type 2 diabetesCab45Insulin granulesBiogenesisB cellsSecretory cellsHuman donor isletsPancreatic B-cellsInsulin secretionType 2 diabetesG-locallyChaperoneT2DObese humansInsulinProteinHomeostasisPathwayGranulesBeyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation
Holendová B, Šalovská B, Benáková Š, Plecitá-Hlavatá L. Beyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation. Metabolism 2024, 161: 156027. PMID: 39260557, DOI: 10.1016/j.metabol.2024.156027.Peer-Reviewed Original ResearchPost-translational modificationsReactive oxygen speciesEndoplasmic reticulumTricarboxylic acidRedox signalingPancreatic B-cellsGlucose stimulationModification of proteinsB-cell metabolismRedox signaling pathwaysReversible cysteine oxidationIncreased ROS levelsProduction of reactive oxygen speciesB cell functionInsulin secretionB cellsProtein functionProtein processingCysteine thiol modificationsGlucose-induced increaseOxidative phosphorylationPyruvate metabolismProtein activityRegulatory mechanismsMetabolic pathwaysThe immunology of type 1 diabetes
Herold K, Delong T, Perdigoto A, Biru N, Brusko T, Walker L. The immunology of type 1 diabetes. Nature Reviews Immunology 2024, 24: 435-451. PMID: 38308004, PMCID: PMC7616056, DOI: 10.1038/s41577-023-00985-4.Peer-Reviewed Original ResearchType 1 diabetesT cellsDestruction of pancreatic B-cellsImmune-targeted interventionsTarget T cellsPathogenesis of T1DB-cell massPancreatic B-cellsAutoimmune destructionB cellsGlucose dysregulationImmune mechanismsImmune systemNatural historyDisease pathogenesisT1DRegulatory approvalTreatment of individualsDiscovery of insulinPathogenesisDiseaseSeminal discoveriesImmunotherapy
2012
AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells
Wu Z, Zhu L, Zou N, Bombek L, Shao C, Wang N, Wang X, Liang L, Xia J, Rupnik M, Shen Y. AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells. Traffic 2012, 13: 1124-1139. PMID: 22540213, DOI: 10.1111/j.1600-0854.2012.01373.x.Peer-Reviewed Original ResearchConceptsK(ATP) channelsGlutamate applicationB cellsInsulin releaseA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorIonotropic glutamate receptorsKnock-out miceDepolarization-induced exocytosisMouse B cellsInsulin-containing granulesPancreatic B-cellsGlutamate receptorsCytosolic calciumCytosolic cGMPAMPARAcid receptorsInsulin secretionInsulinoma cellsInsulinGlutamateMiceReceptorsExocytosisIGluRsRelease
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