2024
TMED4 facilitates Treg suppressive function via ROS homeostasis in tumor and autoimmune mouse models
Jiang Z, Wang H, Wang X, Duo H, Tao Y, Li J, Li X, Liu J, Ni J, Wu E, Xiang H, Guan C, Wang X, Zhang K, Zhang P, Hou Z, Liu Y, Wang Z, Su B, Li B, Hao Y, Li B, Wu X. TMED4 facilitates Treg suppressive function via ROS homeostasis in tumor and autoimmune mouse models. Journal Of Clinical Investigation 2024, 135: e179874. PMID: 39480507, PMCID: PMC11684806, DOI: 10.1172/jci179874.Peer-Reviewed Original ResearchEndoplasmic reticulum stressER-associated degradationSuppressive functionTreg cellsFoxp3 stabilityReactive oxygen speciesSuppressive function of Treg cellsFunction of Treg cellsExacerbated inflammatory phenotypeAnti-tumor immunityTreg suppressive functionRegulatory T cellsTreg cell stabilityT cell hyperactivationAutoimmune mouse modelReactive oxygen species homeostasisTreg signatureT cellsTregsInflammatory phenotypeReactive oxygen species scavengingMouse modelTMED4Excessive reactive oxygen speciesProtein 4
2018
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications 2018, 9: 3157. PMID: 30089837, PMCID: PMC6082899, DOI: 10.1038/s41467-018-05676-6.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsAntineoplastic AgentsAutoimmunityBasic-Leucine Zipper Transcription FactorsBone Marrow CellsCD4-Positive T-LymphocytesCell DifferentiationCell Line, TumorCell NucleusCysteine EndopeptidasesFemaleGene DeletionGene Expression ProfilingGene Expression RegulationHEK293 CellsHomeostasisHumansImmune ToleranceLymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutPeptide HydrolasesReactive Oxygen SpeciesSumoylationT-Lymphocytes, RegulatoryConceptsRegulatory T cellsTreg cellsT cellsReactive oxygen speciesSUMO-specific protease 3T effector cell differentiationAntitumor T-cell responsesTreg cell-specific deletionT cell responsesEffector cell differentiationTreg cell stabilityCell-specific deletionT cell activationImmune toleranceTumor immunosuppressionAutoimmune symptomsImmune homeostasisRegulation of ROSRole of SENP3Cell activationCell responsesGene signatureProtease 3Pivotal regulatorNuclear export
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply