2025
The role of tight junctions in the pathogenesis of inflammatory bowel disease: immune modulation and barrier dysfunction
Heo J, Kim M, Yang Y, Choi H, Kim K, Oh T, Yang J, Kim Y, Park K. The role of tight junctions in the pathogenesis of inflammatory bowel disease: immune modulation and barrier dysfunction. Molecular & Cellular Toxicology 2025, 21: 495-506. DOI: 10.1007/s13273-025-00545-y.Peer-Reviewed Original ResearchInflammatory bowel diseaseIncreased epithelial permeabilityPathogenesis of inflammatory bowel diseaseBowel diseaseTight junctionsEpithelial permeabilityDisease progressionTherapeutic strategiesDisruption of tight junctionsRelease of proinflammatory cytokinesTumor necrosis factor-alphaPathophysiology of inflammatory bowel diseaseTight junction dysfunctionTight junction regulationTight junction disruptionTight junction integrityTight junction structureImmune cell activationMucosal immune systemRegulate paracellular transportNecrosis factor-alphaIntestinal tight junctionsInflammatory bowel disease managementNuclear factor kappa BInterleukin-1 betaAssociations of TNF-Α -308 and -238 Polymorphisms with Inflammatory Bowel Disease: A Case-Control Study and Meta-Analysis of Published Data
Moosavi S, Shanker A, Sadr M, Soltani S, Shahkarami S, Farhadi E, Daryani N, Noveiry B, Varzaneh F, Bashashati M, Rezaei N. Associations of TNF-Α -308 and -238 Polymorphisms with Inflammatory Bowel Disease: A Case-Control Study and Meta-Analysis of Published Data. Immunology And Genetics Journal 2025 DOI: 10.18502/igj.v8i2.18003.Peer-Reviewed Original ResearchInflammatory bowel diseaseSingle nucleotide polymorphismsTNF-aMeta-analysisGene polymorphismsChronic relapsing-remitting inflammatory diseaseHealthy controlsBowel diseaseTumor necrosis factor-alphaAssociated with inflammatory bowel diseaseSusceptibility to inflammatory bowel diseasePathogenesis of inflammatory bowel diseaseNecrosis factor-alphaCase-control studySequence-specific primersFactor-alphaIranian patientsPolymerase chain reactionPCR-SSPInflammatory diseasesGenotype statusNucleotide polymorphismsAllele frequenciesCase-controlPatients
2024
DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells
Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell R, Liu Z, Li M, Pan W, Zhu S. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications 2024, 15: 3080. PMID: 38594251, PMCID: PMC11004185, DOI: 10.1038/s41467-024-47235-2.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIntestinal stem cellsIntestinal epithelial cellsEpithelial homeostasisSusceptibility to experimental colitisIncreased susceptibility to experimental colitisImpaired ISC functionStem cellsEpithelial barrier dysfunctionGenomic instabilityInflammatory bowel disease patientsPathogenesis of inflammatory bowel diseaseR-loop-mediated genome instabilityHallmarks of inflammatory bowel diseaseContinuous self-renewalBarrier dysfunctionExperimental colitisCrypt destructionEpithelial cellsInflammatory responseSelf-RenewalBowel diseaseRisk factorsIntestinal epitheliumProtein levels
2021
Roles of microRNAs in inflammatory bowel disease
Jung H, Kim J, Lee K, Tizaoui K, Terrazzino S, Cargnin S, Smith L, Koyanagi A, Jacob L, Li H, Hong S, Yon D, Lee S, Kim M, Wasuwanich P, Karnsakul W, Shin J, Kronbichler A. Roles of microRNAs in inflammatory bowel disease. International Journal Of Biological Sciences 2021, 17: 2112-2123. PMID: 34131410, PMCID: PMC8193269, DOI: 10.7150/ijbs.59904.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseRegulate gene expressionBowel diseaseSamples of IBD patientsTreatment of inflammatory bowel diseasePathogenesis of inflammatory bowel diseaseRNA moleculesSerum samples of IBD patientsChronic inflammatory diseaseTreat inflammatory bowel diseaseGene expressionHost immune responseIntestinal bacteriaQuality of life of patientsSignaling pathwayIntestinal barrierIntestinal epitheliumLife of patientsGastrointestinal symptomsIntracolonic administrationPathophysiological mechanismsIBD patientsInflammatory diseasesImmune responseColon tissues
2017
IBD immunopathogenesis: A comprehensive review of inflammatory molecules
Park J, Peyrin-Biroulet L, Eisenhut M, Shin J. IBD immunopathogenesis: A comprehensive review of inflammatory molecules. Autoimmunity Reviews 2017, 16: 416-426. PMID: 28212924, DOI: 10.1016/j.autrev.2017.02.013.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseInflammatory moleculesCrohn's diseaseUlcerative colitisPathogenesis of inflammatory bowel diseaseExpression of pro-Potential therapeutic targetNovel moleculesMoleculesChronic inflammatory conditionsIntestinal inflammatory processAnti-inflammatory moleculesTherapeutic target
2016
Insight into the role of TSLP in inflammatory bowel diseases
Park J, Jeong D, Peyrin-Biroulet L, Eisenhut M, Shin J. Insight into the role of TSLP in inflammatory bowel diseases. Autoimmunity Reviews 2016, 16: 55-63. PMID: 27697608, DOI: 10.1016/j.autrev.2016.09.014.Peer-Reviewed Original ResearchConceptsThymic stromal lymphopoietinInflammatory bowel diseaseUlcerative colitisCrohn's diseaseDendritic cellsT cellsAtopic dermatitisDifferentiation of regulatory T cellsDominant diseaseBowel diseaseIncreased TSLPMucosal dendritic cellsPolarization of T cellsRegulatory T cellsPathogenesis of inflammatory bowel diseaseTSLP's roleSecretion of IgAEosinophilic esophagitisTh2 responsesB cellsProinflammatory cytokinesAllergic diseasesDiseaseCytokinesPathogeneses
1998
Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease.
Müller S, Lory J, Corazza N, Griffiths G, Z'graggen K, Mazzucchelli L, Kappeler A, Mueller C. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. American Journal Of Pathology 1998, 152: 261-8. PMID: 9422543, PMCID: PMC1858122.Peer-Reviewed Original ResearchConceptsPerforin mRNA-expressing cellsInflammatory bowel diseaseMRNA-expressing cellsCytotoxic cellsGranzyme ACrohn's diseaseCD8+ T cellsCD8+ cytotoxic cellsBowel diseaseLamina propriaActive inflammatory bowel diseaseActivated cytotoxic cellsIntestinal mucosa of patientsActivated CD4+Cell-mediated cytotoxicityPathogenesis of inflammatory bowel diseaseMucosa of patientsIntestinal mucosaEpithelial cell layerSections of controlPerforin expressionCD4+Cells in situEpithelial compartmentT cells
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply