Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease.
Müller S, Lory J, Corazza N, Griffiths G, Z'graggen K, Mazzucchelli L, Kappeler A, Mueller C. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. American Journal Of Pathology 1998, 152: 261-8. PMID: 9422543, PMCID: PMC1858122.Peer-Reviewed Original ResearchConceptsPerforin mRNA-expressing cellsInflammatory bowel diseaseMRNA-expressing cellsCytotoxic cellsGranzyme ACrohn's diseaseCD8+ T cellsCD8+ cytotoxic cellsBowel diseaseLamina propriaActive inflammatory bowel diseaseActivated cytotoxic cellsIntestinal mucosa of patientsActivated CD4+Cell-mediated cytotoxicityPathogenesis of inflammatory bowel diseaseMucosa of patientsIntestinal mucosaEpithelial cell layerSections of controlPerforin expressionCD4+Cells in situEpithelial compartmentT cells
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