2024
Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes
Germanos M, Yau B, Taper M, Yeoman C, Wilson A, An Y, Cattin-Ortolá J, Masler D, Tong J, Naghiloo S, Needham E, van der Kraan A, Sun K, Loudovaris T, Diaz-Vegas A, Larance M, Thomas H, von Blume J, Thorn P, Ailion M, Asensio C, Kebede M. Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes. IScience 2024, 28: 111719. PMID: 39898024, PMCID: PMC11787600, DOI: 10.1016/j.isci.2024.111719.Peer-Reviewed Original ResearchInsulin granule biogenesisGranule biogenesisSecretory granule biogenesisSpecialized secretory cellsInsulin secretory pathwaySecretory pathwayHuman type 2 diabetesCab45Insulin granulesBiogenesisB cellsSecretory cellsHuman donor isletsPancreatic B-cellsInsulin secretionType 2 diabetesG-locallyChaperoneT2DObese humansInsulinProteinHomeostasisPathwayGranules
2023
Rediscovering the intricacies of secretory granule biogenesis
Campelo F, Tian M, von Blume J. Rediscovering the intricacies of secretory granule biogenesis. Current Opinion In Cell Biology 2023, 85: 102231. PMID: 37657367, DOI: 10.1016/j.ceb.2023.102231.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkSG biogenesisRegulated secretionImmature SGsEssential cellular processesSecretory granulesSecretory granule biogenesisImmature secretory granulesCargo selectionCargo receptorsCellular processesGranule biogenesisGranule cargoCargo moleculesBiogenesisBiophysical mechanismsDisease mechanismsCellular communicationCargoCentral roleDiverse rangeNew lightTraffickingMechanismProtein
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