2024
Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes
Germanos M, Yau B, Taper M, Yeoman C, Wilson A, An Y, Cattin-Ortolá J, Masler D, Tong J, Naghiloo S, Needham E, van der Kraan A, Sun K, Loudovaris T, Diaz-Vegas A, Larance M, Thomas H, von Blume J, Thorn P, Ailion M, Asensio C, Kebede M. Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes. IScience 2024, 28: 111719. PMID: 39898024, PMCID: PMC11787600, DOI: 10.1016/j.isci.2024.111719.Peer-Reviewed Original ResearchInsulin granule biogenesisGranule biogenesisSecretory granule biogenesisSpecialized secretory cellsInsulin secretory pathwaySecretory pathwayHuman type 2 diabetesCab45Insulin granulesBiogenesisB cellsSecretory cellsHuman donor isletsPancreatic B-cellsInsulin secretionType 2 diabetesG-locallyChaperoneT2DObese humansInsulinProteinHomeostasisPathwayGranules
2003
A General Role for Rab27a in Secretory Cells
Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths G, Huxley C, Seabra M. A General Role for Rab27a in Secretory Cells. Molecular Biology Of The Cell 2003, 15: 332-344. PMID: 14617806, PMCID: PMC307551, DOI: 10.1091/mbc.e03-07-0452.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEndocrine GlandsExocrine GlandsExocytosisFemaleGastrointestinal TractGene Expression RegulationGreen Fluorescent ProteinsImmunohistochemistryLuminescent ProteinsMiceMice, TransgenicMicroscopy, ElectronOvaryrab GTP-Binding Proteinsrab27 GTP-Binding Proteinsrab3 GTP-Binding ProteinsRecombinant Fusion ProteinsTissue DistributionConceptsSecretory cellsComplex pattern of expressionSpecialized secretory cellsFunction of proteinsCell-specific expressionSpecialized cell typesRab3 proteinsPattern of expressionRab GTPasesVesicular transportComplex multistep processFusion proteinRab27aMammalian organismsSecretory eventsCell typesProteinMultistep processGeneral roleHematopoietic cellsKnockout miceCellsComplex patternsRab3GTPase
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