2020
P37 Convergent somatic mutations in effectors of insulin signalling in chronic liver disease
Ng S, Brunner S, Brzozowska N, Aitken S, Abascal F, Moore L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders M, Williams N, Coorens T, Teague J, Raine K, Butler A, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies S, Stratton M, Martincorena I, Hoare M, Campbell P. P37 Convergent somatic mutations in effectors of insulin signalling in chronic liver disease. Gut 2020, 69: a25-a25. DOI: 10.1136/gutjnl-2020-basl.47.Peer-Reviewed Original ResearchChronic liver diseaseLiver diseaseSomatic mutationsAssociated with metabolic dysregulationSystemic metabolic dysfunctionNon-alcoholic fatty liver diseaseFatty liver diseaseInsulin signalingEffectors of insulin signalingLiver failureHepatocellular carcinomaMultiple independent acquisitionsGram of tissueDownstream of insulin signalingMetabolic dysfunctionMetabolic dysregulationNormal controlsPatient samplesLiver samplesExcess of mutationsNormal liverDietary caloriesLiverAlcohol-relatedDisease
2008
Reproducibility of single‐ and multi‐voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intake
Shen W, Mao X, Wolper C, Heshka S, Dashnaw S, Hirsch J, Heymsfield SB, Shungu DC. Reproducibility of single‐ and multi‐voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intake. NMR In Biomedicine 2008, 21: 498-506. PMID: 17955571, PMCID: PMC2892914, DOI: 10.1002/nbm.1218.Peer-Reviewed Original ResearchConceptsIntramyocellular lipidsLean subjectsSV-MRSTotal muscle creatineTibialis anterior muscleOverweight subjectsFat intakeDietary fatAnterior muscleCalorie intakeMuscle creatineFemale CaucasiansDietary caloriesDuplicate measuresMRS measurementsIntakeMRSISubjectsShorter scan timeTCRDaysOverweightLipidsCoefficient of variation
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