2022
QOPI Clinical Informatics: A digital platform to enable real-time quality reporting, clinical decision support, and rapid learning.
Williams C, Karagoz K, Elsey R, Meißner T, Higashi M, Schadt E, Jun T, Wang X, Chen R, Zhou X, Guin S, Lee J, Oh W. QOPI Clinical Informatics: A digital platform to enable real-time quality reporting, clinical decision support, and rapid learning. Journal Of Clinical Oncology 2022, 40: e13545-e13545. DOI: 10.1200/jco.2022.40.16_suppl.e13545.Peer-Reviewed Original ResearchQuality Oncology Practice InitiativeClinical decision supportDecision supportData visualization techniquesCancer careClinical Oncology Quality Oncology Practice InitiativeASCO's Quality Oncology Practice InitiativeTemporal reasoningPractice initiativesBreast cancer patientsInteractive graphsTumor molecular profilingVisual platformData curationNLP methodsMolecular tumor boardPatient referral patternsAmerican SocietyVisualization techniquesContinuous learning environmentData captureClinical informaticsRapid learningDigital platformsQuality reportingLandscape of tumor genetic testing and targeted therapies over an eight-year span in a rural population.
Williams C, Guin S, Elsey R, Meißner T, Xu B, Sun Y, Amallraja A, Jun T, Schadt E, Chen R, Zhou X, Higashi M, Lee J, Oh W. Landscape of tumor genetic testing and targeted therapies over an eight-year span in a rural population. Journal Of Clinical Oncology 2022, 40: e15036-e15036. DOI: 10.1200/jco.2022.40.16_suppl.e15036.Peer-Reviewed Original ResearchAdvanced breast cancer patientsBreast cancer patientsTargeted therapyTargetable mutationsCancer patientsElectronic medical recordsNCCN guidelinesLabel useBRCA1/2 mutationsStage IIITumor typesNon-small cell lung cancerAdvanced prostate cancer patientsKRAS/NRAS mutationsReal-world patient populationPositive NGS resultsAdvanced breast cancerNGS resultsAdvanced-stage patientsCell lung cancerBRAF V600 mutationTumor molecular profilingProstate cancer patientsTumor genetic testingMolecular tumor board
2020
Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy
Kato S, Kim K, Lim H, Boichard A, Nikanjam M, Weihe E, Kuo D, Eskander R, Goodman A, Galanina N, Fanta P, Schwab R, Shatsky R, Plaxe S, Sharabi A, Stites E, Adashek J, Okamura R, Lee S, Lippman S, Sicklick J, Kurzrock R. Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy. Nature Communications 2020, 11: 4965. PMID: 33009371, PMCID: PMC7532150, DOI: 10.1038/s41467-020-18613-3.Peer-Reviewed Original ResearchConceptsMolecular tumor boardOverall survivalTumor boardNext-generation sequencingReviewed patient characteristicsResistant to monotherapyProgression-FreeOncological outcomesRemission rateChoice regimenGenomic alterationsPatient characteristicsRecommended drugsMolecular findingsPatientsTherapyMaster protocolCancer targetPhysician-directedPFSPrecision strategySurvivalDrugMedication accessOutcomes
2017
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study
Ghazani AA, Oliver NM, St Pierre JP, Garofalo A, Rainville IR, Hiller E, Treacy DJ, Rojas-Rudilla V, Wood S, Bair E, Parello M, Huang F, Giannakis M, Wilson FH, Stover EH, Corsello SM, Nguyen T, Rana HQ, Church AJ, Lowenstein C, Cibulskis C, Amin-Mansour A, Heng J, Brais L, Santos A, Bauer P, Waldron A, Lo P, Gorman M, Lydon CA, Welch M, McNamara P, Gabriel S, Sholl LM, Lindeman NI, Garber JE, Joffe S, Van Allen EM, Gray SW, Ja Nne P, Garraway LA, Wagle N. Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study. Genetics In Medicine 2017, 19: 787-795. PMID: 28125075, DOI: 10.1038/gim.2016.191.Peer-Reviewed Original ResearchConceptsClinical evidenceCancer precision medicineWhole-exome sequencing dataPrecision medicineMolecular tumor boardTumor biopsy samplesGerm-line alterationsGerm-line variantsProtocol-based approachPrecision medicine studiesMetastatic colorectalPatient preferencesTumor boardLung adenocarcinomaClinical careBlood samplesBiopsy samplesClinical relevanceClinical teamClinical meaningTherapeutic relevanceUnknown significanceVariant reviewMedicine studiesGenomic alterations
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