2023
Bacterial antigens unleash tumor-targeting immunity
Boeck N, Trajanoski Z, Galluzzi L. Bacterial antigens unleash tumor-targeting immunity. Cell Host & Microbe 2023, 31: 1945-1947. PMID: 38096784, PMCID: PMC11075005, DOI: 10.1016/j.chom.2023.11.001.Peer-Reviewed Original Research
2020
Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants
Kadriu B, Greenwald M, Henter ID, Gilbert JR, Kraus C, Park LT, Zarate CA. Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants. The International Journal Of Neuropsychopharmacology 2020, 24: 8-21. PMID: 33252694, PMCID: PMC7816692, DOI: 10.1093/ijnp/pyaa087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsKetamine researchSerotonergic psychedelicsAntidepressant effectsAntidepressant efficacyRapid-acting antidepressantsRapid acting antidepressantsGlutamatergic modulator ketamineCortical network activityDownstream pharmacological effectsActivity-dependent mannerAcute alterationsTherapeutic responseNeuroplastic effectsGlutamatergic pathwaysPharmacological effectsKetaminePsychoactive componentTherapeutic relevanceAntidepressantsDownstream mechanismsPsychoactive effectsMolecular effectsNetwork activityCommon mechanismEfficacy
2019
Severe asthma with blood hypereosinophilia associated with JAK2 V617F mutation: a case series
Tabèze L, Marchand-Adam S, Borie R, Justet A, Dupin C, Dombret M, Crestani B, Taillé C. Severe asthma with blood hypereosinophilia associated with JAK2 V617F mutation: a case series. European Respiratory Journal 2019, 53: 1802248. PMID: 31000675, DOI: 10.1183/13993003.02248-2018.Peer-Reviewed Original ResearchConceptsT helper type 2 cellsBlood eosinophil count >Allergic bronchopulmonary aspergillosisEosinophil count >JAK2 V617F mutationType 2 cellsBronchopulmonary aspergillosisLymphoid neoplasmsV617F mutationHaematological disordersTargeted therapyCase seriesBlood eosinophiliaSevere asthmaAsthmatic patientsRespiratory manifestationsHypereosinophiliaUncontrolled asthmaAsthma patientsTherapeutic relevancePatientsAsthmaBloodParasitic infectionsAspergillosis
2017
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study
Ghazani AA, Oliver NM, St Pierre JP, Garofalo A, Rainville IR, Hiller E, Treacy DJ, Rojas-Rudilla V, Wood S, Bair E, Parello M, Huang F, Giannakis M, Wilson FH, Stover EH, Corsello SM, Nguyen T, Rana HQ, Church AJ, Lowenstein C, Cibulskis C, Amin-Mansour A, Heng J, Brais L, Santos A, Bauer P, Waldron A, Lo P, Gorman M, Lydon CA, Welch M, McNamara P, Gabriel S, Sholl LM, Lindeman NI, Garber JE, Joffe S, Van Allen EM, Gray SW, Ja Nne P, Garraway LA, Wagle N. Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study. Genetics In Medicine 2017, 19: 787-795. PMID: 28125075, DOI: 10.1038/gim.2016.191.Peer-Reviewed Original ResearchConceptsClinical evidenceCancer precision medicineWhole-exome sequencing dataPrecision medicineMolecular tumor boardTumor biopsy samplesGerm-line alterationsGerm-line variantsProtocol-based approachPrecision medicine studiesMetastatic colorectalPatient preferencesTumor boardLung adenocarcinomaClinical careBlood samplesBiopsy samplesClinical relevanceClinical teamClinical meaningTherapeutic relevanceUnknown significanceVariant reviewMedicine studiesGenomic alterations
2013
Notch signaling and new therapeutic options in liver disease
Morell CM, Strazzabosco M. Notch signaling and new therapeutic options in liver disease. Journal Of Hepatology 2013, 60: 885-890. PMID: 24308992, DOI: 10.1016/j.jhep.2013.11.028.Peer-Reviewed Original ResearchConceptsLiver diseaseTherapeutic agentsNew therapeutic optionsNotch signalingSpecific therapeutic agentsStem cell featuresTherapeutic optionsLiver malignanciesLiver metabolismTherapeutic relevanceAberrant activationLiver regenerationPersistent activationDiseaseAdult liverPossible targetsFurther studiesCell featuresNovel findingsRecent reportsNotch pathwayLiverCritical playersSignalingActivation
2005
Engraftment of Bone Marrow‐Derived Epithelial Cells
Krause DS. Engraftment of Bone Marrow‐Derived Epithelial Cells. Annals Of The New York Academy Of Sciences 2005, 1044: 117-124. PMID: 15958704, DOI: 10.1196/annals.1349.015.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsEpithelial cellsMarrow-derived epithelial cellsNonhematopoietic cellsLevel of engraftmentCell plasticityStem cell plasticityAllogeneic settingAdult stem cell plasticityBM cellsBuccal mucosaGastrointestinal tractBone marrowTissue damageEngraftmentFunctional epithelial cellsTherapeutic relevanceNonhematopoietic cell typesPrecursor cellsMost reportsDiseased organsLungMarrowDifferent phenotypes
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