2022
MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice
Wang T, Xiao Y, Hu Z, Gu J, Hua R, Hai Z, Chen X, Zhang J, Yu Z, Wu T, Yeung W, Liu K, Guo C. MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice. Frontiers In Cell And Developmental Biology 2022, 10: 862506. PMID: 35493072, PMCID: PMC9046932, DOI: 10.3389/fcell.2022.862506.Peer-Reviewed Original ResearchConditional knock-outMitochondrial functionPPAR pathwayMale germ cellsRNA-seq analysisGenes up-regulatedGenes down-regulatedPathway enrichment analysisImpaired mitochondrial functionDynamic organellesMitochondrial dynamicsRNA-seqMitochondrial fusionDisrupted spermatogenesisMfn2 deficiencyGerm cellsPachytene stageOxidative phosphorylationSpermatogenesisTranscriptome profilingEnrichment analysisMfn2Cellular differentiationMolecular mechanismsLipid droplets
2021
Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation
Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. Journal Of Leukocyte Biology 2021, 111: 771-791. PMID: 34494308, PMCID: PMC8901796, DOI: 10.1002/jlb.1a0720-471r.Peer-Reviewed Original ResearchConceptsΒ2 integrin activationIntegrin activationMitofusin 2Mfn2 deficiencyConformation-specific monoclonal antibodiesMFN2 knockdownHL60 cellsNeutrophil-like HL60 cellsMolecular detailsActin polymerizationCell spreadingAdhesion defectsReduced expressionInnate immunityKnockdownNew insightsActivationCellsLeukocyte adhesionAdhesionCell rollingCrucial stepMonoclonal antibodiesDifferentiationVascular endothelium
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