2024
Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy SEQUOIA-HCM CMR Substudy
Masri A, Cardoso R, Abraham T, Claggett B, Coats C, Hegde S, Kulac I, Lee M, Maron M, Merkely B, Michels M, Olivotto I, Oreziak A, Jacoby D, Heitner S, Kupfer S, Malik F, Meng L, Solomon S, Wohltman A, Kwong R, Kramer C, Investigators S. Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy SEQUOIA-HCM CMR Substudy. Journal Of The American College Of Cardiology 2024, 84: 1806-1817. PMID: 39217563, DOI: 10.1016/j.jacc.2024.08.015.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceObstructive hypertrophic cardiomyopathyOutflow tract obstructionReduce cardiovascular eventsCardiac remodelingAtrial fibrillationHeart failureCardiovascular eventsAssociated with progressive heart failureLeft ventricular (LV) hypertrophyPhase 3 double-blindSymptomatic obstructive hypertrophic cardiomyopathyLV outflow tract obstructionMaximal LV wall thicknessLeft atrial volume indexAtrial volume indexLV mass indexLV) hypertrophyPlacebo-controlled trialProgressive heart failureFavorable cardiac remodelingLeft atrial dilatationCardiac myosin inhibitorLeft atrial sizeLV wall thickness
2020
Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study
Kim J, Lee Y, Kang H, Ha I, Cheong H, Choi H, Han K, Kim S, Cho M, Shin J, Lee J, Park Y, Cho H. Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study. BMC Nephrology 2020, 21: 533. PMID: 33297989, PMCID: PMC7724800, DOI: 10.1186/s12882-020-02152-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnemiaAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsChildChild, PreschoolCohort StudiesDiastoleFemaleGlomerular Filtration RateHumansHypertrophy, Left VentricularInfantLogistic ModelsMaleMultivariate AnalysisProspective StudiesRenal Insufficiency, ChronicRepublic of KoreaRisk FactorsVentricular Dysfunction, LeftConceptsLeft ventricular (LV) hypertrophyAssociated with LV diastolic dysfunctionLV diastolic dysfunctionLV mass indexPediatric chronic kidney diseaseChronic kidney diseaseRisk of LV diastolic dysfunctionPediatric CKD patientsLow hemoglobin levelKidney diseaseZ-scoreDiastolic dysfunctionCKD patientsHemoglobin levelsEarly filling to early diastolic mitral annular velocityPrevalence of left ventricular (LV) hypertrophyPrevalence of LV diastolic dysfunctionCohort studyEarly diastolic mitral annular velocityDiastolic mitral annular velocityLeft ventricular diastolic dysfunctionRisk factorsHigher LV mass indexMale to female ratioMitral peak velocitySafety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study
Qureshi M, Patterson M, Clark V, Johnson J, Moutvic M, Driscoll S, Kemppainen J, Huston J, Anderson J, Badley A, Tebben P, Wackel P, Oglesbee D, Glockner J, Schreiner G, Dugar S, Touchette J, Gavrilova R. Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study. Journal Of Inherited Metabolic Disease 2020, 44: 502-514. PMID: 32677106, DOI: 10.1002/jimd.12285.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonance imagingMagnetic resonance imagingOpen-labelCardiac endpointsLeft ventricular (LV) structureFriedreich Ataxia Rating ScaleImprovement of cardiac functionLV mass indexSingle-center trialFriedreich's ataxiaCompared to baselineAtaxia Rating ScaleNonstatistically significant improvementPhase IIFA diagnosisStatistically significant improvementNeurological outcomeSignificant improvementPediatric subjectsAdverse eventsProspective studyCardiac functionHeart failureCardiac structureEvaluate safety
2017
Influence of the Method of Definition on the Prevalence of Left-Ventricular Hypertrophy in Children with Chronic Kidney Disease: Data from the Know-Ped CKD Study
Cho H, Choi H, Kang H, Ha I, Cheong H, Han K, Kim S, Cho M, Shin J, Lee J, Park Y. Influence of the Method of Definition on the Prevalence of Left-Ventricular Hypertrophy in Children with Chronic Kidney Disease: Data from the Know-Ped CKD Study. Kidney & Blood Pressure Research 2017, 42: 406-415. PMID: 28689198, DOI: 10.1159/000478867.Peer-Reviewed Original ResearchConceptsLV mass indexPediatric chronic kidney diseaseChronic kidney diseasePrevalence of LVHPediatric CKD patientsAge-specific reference valuesZ-score >CKD patientsDiagnosis of LVHKidney diseaseCardiac dysfunctionLeft ventricularCohort studyPrevalence of left ventricular hypertrophyPre-dialysis CKD patientsZ-scorePredicting cardiac dysfunctionCardiovascular diseaseThirty-one patientsMarkers of cardiovascular diseasePediatric CKD cohortsLeft ventricular hypertrophyMultiple logistic regression analysisRisk of cardiovascular diseaseKorean Cohort Study
2011
Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both
Shah AM, Hung CL, Shin SH, Skali H, Verma A, Ghali JK, Køber L, Velazquez EJ, Rouleau JL, McMurray JJ, Pfeffer MA, Solomon SD. Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. American Heart Journal 2011, 162: 685-691. PMID: 21982661, DOI: 10.1016/j.ahj.2011.07.015.Peer-Reviewed Original ResearchConceptsLV mass indexRisk of deathRelative wall thicknessDiabetic patientsEjection fractionMass indexHigh riskBaseline LV mass indexLeft ventricular systolic dysfunctionHigher LV mass indexHeart failure post-myocardial infarctionVALIANT Echo studyAtrial volume indexVentricular systolic dysfunctionAge-adjusted modelsQuantitative echocardiographic analysisPost-myocardial infarctionHF hospitalizationLong-term elevationNondiabetic patientsConcentric remodelingSystolic dysfunctionAtrial enlargementHeart failureClinical outcomes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply