2019
Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder
Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina J, Dickerson B, Keshavan M, LaFrance W, Sepulcre J, Perez D. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 929. PMID: 30850473, PMCID: PMC6625895, DOI: 10.1136/jnnp-2018-319657.Peer-Reviewed Original ResearchConceptsFunctional neurological disorderLeft anterior insulaRight anterior insulaAnterior insulaSymptom severityWithin-group analysisPathophysiology of functional neurological disorderFunctional neurological disorder cohortsMotor functional neurological disorderRight laterobasal amygdalaMultimodal integration networkBilateral posterior insulaMiddle cingulate cortexMultimodal integration areasLaterobasal amygdalaDisorder subscaleCentromedial amygdalaCingulate cortexInteroceptive processingAffective disturbancesPatient-reported symptom severityPosterior insulaWithin-group associationsAmygdalar nucleiBetween-group differences
2017
Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders
Perez D, Matin N, Barsky A, Costumero-Ramos V, Makaretz S, Young S, Sepulcre J, LaFrance W, Keshavan M, Dickerson B. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. Journal Of Neurology Neurosurgery & Psychiatry 2017, 88: 491. PMID: 28416565, PMCID: PMC5497745, DOI: 10.1136/jnnp-2016-314998.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexChildChild AbuseConversion DisorderDominance, CerebralFemaleGray MatterGyrus CinguliHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalLife Change EventsMagnetic Resonance ImagingMaleMiddle AgedNervous System DiseasesOrgan SizePsychophysiologic DisordersStatistics as TopicStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional neurological symptomsFunctional neurological disorderAnterior cingulate cortexSelf-report measuresInsular volumeChildhood abuseVolumetric associationsSymptom severityPost-traumatic stress disorder symptom severityAssociated with left hippocampal volumeAdverse early-life eventsFunctional neurological disorder patientsLeft hippocampal volumeAdverse life eventsPatient Health Questionnaire-15Neurological symptom severityEarly-life eventsACC volumeDisorder subscaleGender-specific effectsCingulate cortexStress disorderHippocampal volume
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