2023
Molecular insights into the force-from-lipids gating of mechanosensitive channels
Bavi N, Cox C, Nikolaev Y, Martinac B. Molecular insights into the force-from-lipids gating of mechanosensitive channels. Current Opinion In Physiology 2023, 36: 100706. DOI: 10.1016/j.cophys.2023.100706.Peer-Reviewed Original ResearchMS channel gatingChannel gatingLipid bilayersMechanosensitive ion channelsLipid principleMechanosensitive channelsChannel proteinsPhysiological processesMolecular underpinningsMolecular insightsMembrane tensionIon channelsMolecular interactionsMechanical forcesCurrent understandingBilayer thinningNew insightsGatingBilayersBlood pressure regulationProteinRegulationInsightsCellsPressure regulationInsights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter
Sharda A, Gu S, Hwa J. Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter. Nature Cardiovascular Research 2023, 2: 606-608. PMID: 37655224, PMCID: PMC10470688, DOI: 10.1038/s44161-023-00293-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Is it the time to integrate novel sequencing technologies into clinical practice?
VanOudenhove J, Halene S, Mendez L. Is it the time to integrate novel sequencing technologies into clinical practice? Current Opinion In Hematology 2022, 30: 70-77. PMID: 36602939, DOI: 10.1097/moh.0000000000000754.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNovel sequencing technologiesSequencing technologiesUnprecedented biological insightsNext-generation sequencing techniquesDNA sequencing technologiesHigh-throughput NGSRare cell populationsBiological insightsMultiomics approachSequencing techniquesGenotype-phenotype correlationClonal diversityCellular resolutionMechanistic insightsCell populationsPhenotype correlationMyeloid diseasesClonesClonal hierarchyClonal haematopoiesisResidual clonesInsightsSeqDiversityImproved captureWhat next for eating disorder genetics? Replacing myths with facts to sharpen our understanding
Huckins LM, Signer R, Johnson J, Wu YK, Mitchell KS, Bulik CM. What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding. Molecular Psychiatry 2022, 27: 3929-3938. PMID: 35595976, PMCID: PMC9718676, DOI: 10.1038/s41380-022-01601-y.Peer-Reviewed Original ResearchFemale Health Across the Tree of Life: Insights at the Intersection of Women's Health, One Health and Planetary Health
Natterson-Horowitz B, Boddy AM, Zimmerman D. Female Health Across the Tree of Life: Insights at the Intersection of Women's Health, One Health and Planetary Health. PNAS Nexus 2022, 1: pgac044. PMID: 35668878, PMCID: PMC9154074, DOI: 10.1093/pnasnexus/pgac044.Peer-Reviewed Original ResearchTree of lifeImportance of biodiversityAnimal populationsLevel of resistanceHealth prevention effortsWomen's healthFemale animalsAnimal's environmentBiological characteristicsFemale healthSpeciesEnvironmental factorsTreesComparative approachRich sourceSimilar environmental hazardsHuman healthEndometrial cancerAnimalsBiodiversityNoncommunicable diseasesInterdependence of humansPhysiologic adaptationsInsightsPrevention effortsThe role of PI3Kγ in the immune system: new insights and translational implications
Lanahan SM, Wymann MP, Lucas CL. The role of PI3Kγ in the immune system: new insights and translational implications. Nature Reviews Immunology 2022, 22: 687-700. PMID: 35322259, PMCID: PMC9922156, DOI: 10.1038/s41577-022-00701-8.Peer-Reviewed Original ResearchConceptsProtein structure determinationContext-dependent modulatorNew insightsImmune systemMonogenic immune disordersSpecific PI3Kγ inhibitorInflammatory cytokine releaseRole of PI3KγPI3Kγ deficiencyImmunomodulatory roleCytokine releaseClinical trialsImmune disordersPI3KγTherapeutic targetOncology indicationsTranslational implicationsDrug developmentStructure determinationPI3Kγ inhibitorsRecent advancesPhosphoinositideRoleHumansInsights
2021
Maximizing insights from monogenic immune disorders
Barmada A, Ramaswamy A, Lucas CL. Maximizing insights from monogenic immune disorders. Current Opinion In Immunology 2021, 73: 50-57. PMID: 34695727, PMCID: PMC8915947, DOI: 10.1016/j.coi.2021.09.008.Peer-Reviewed Original ResearchConceptsDisease gene discoveryGene discoverySingle geneIntegrative omicsMonogenic immune disordersHuman diseasesUnprecedented insightsMouse modelingFundamental immune functionsImmune disordersMechanistic studiesGenomeGenomicsImmune functionOmicsDisease discoveryDiscoveryGenesInsightsDisordersDiseaseGenes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases
Gutierrez MJ, Perez GF, Gomez JL, Rodriguez‐Martinez C, Castro‐Rodriguez J, Nino G. Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Pediatric Pulmonology 2021, 56: 3157-3165. PMID: 34388306, PMCID: PMC8858026, DOI: 10.1002/ppul.25598.Peer-Reviewed Original ResearchConceptsDevelopmental timingHistone modificationsPotential molecular mechanismsEpigenetic paradigmEpigenetic reprogrammingGenetic reprogrammingDevelopmental programDNA methylationMolecular mechanismsMolecular programmingReprogrammingEarly originsGenesLatest insightsNew insightsOmicsMethylationMicroRNAsHomeostasisLife-long consequencesInsightsTranslational approachRespiratory mucosaRespiratory diseaseCurrent evidence
2020
Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels
Carlson JC, Weeks DE, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Tuitele J, Deka R, McGarvey ST, Minster RL. Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels. Journal Of Human Genetics 2020, 66: 111-121. PMID: 32759990, PMCID: PMC7785639, DOI: 10.1038/s10038-020-0816-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultApolipoprotein A-IApolipoproteins ECholesterol Ester Transfer ProteinsCholesterol, HDLCholesterol, LDLCohort StudiesFastingFemaleGenetic MarkersGenome-Wide Association StudyHumansLipid MetabolismLipidsMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociSamoaTriglyceridesConceptsGenome-wide association studiesGenetic architectureAssociation studiesGenome-wide significant associationDifferent association signalsUnique population historyPopulation bottlenecksLipid lociPopulation historyAssociation signalsSuggestive associationRab21Current understandingMGAT1Association of variantsReplication cohortLipidsBiological foundationsVariantsLociLow-density lipoproteinInsightsPopulationLipid levelsHigh-density lipoprotein
2018
Genetic Insights Into ADHD Biology
Hayman V, Fernandez TV. Genetic Insights Into ADHD Biology. Frontiers In Psychiatry 2018, 9: 251. PMID: 29930523, PMCID: PMC5999780, DOI: 10.3389/fpsyt.2018.00251.Peer-Reviewed Original ResearchGenome-wide sequencing effortsInteractive gene networksGene discoverySequencing effortsGene networksCandidate genesGenetic insightsExpression patternsBiological pathwaysGenesBiological networksGenetic contributionBiologyPathwayImportant insightsNominal statistical significanceEnrichmentGeneticsBiological underpinningsSynthaseNitric oxide synthaseNeurobiological disorderInsightsHuman developmentExpression
2013
Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?
Rhodes C, White M, Leahy J, Kahn S. Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense? Diabetes 2013, 62: 2157-2163. PMID: 23801714, PMCID: PMC3712043, DOI: 10.2337/db13-0246.Peer-Reviewed Original ResearchConceptsΒ-cellsDirect autocrine effectsTransgenic mouse studiesSignal transductionPancreatic β-cellsDownstream elementsAutocrine actionRelevant ligandsΒ-cell functionAutocrine effectsMouse studiesCircumstantial evidencePhysiological senseTransductionAvailable experimental evidencePathwayInsightsExperimental evidenceInsulin
2012
An integrated encyclopedia of DNA elements in the human genome
Dunham I, Kundaje A, Aldred S, Collins P, Davis C, Doyle F, Epstein C, Frietze S, Harrow J, Kaul R, Khatun J, Lajoie B, Landt S, Lee B, Pauli F, Rosenbloom K, Sabo P, Safi A, Sanyal A, Shoresh N, Simon J, Song L, Trinklein N, Altshuler R, Birney E, Brown J, Cheng C, Djebali S, Dong X, Dunham I, Ernst J, Furey T, Gerstein M, Giardine B, Greven M, Hardison R, Harris R, Herrero J, Hoffman M, Iyer S, Kellis M, Khatun J, Kheradpour P, Kundaje A, Lassmann T, Li Q, Lin X, Marinov G, Merkel A, Mortazavi A, Parker S, Reddy T, Rozowsky J, Schlesinger F, Thurman R, Wang J, Ward L, Whitfield T, Wilder S, Wu W, Xi H, Yip K, Zhuang J, Bernstein B, Birney E, Dunham I, Green E, Gunter C, Snyder M, Pazin M, Lowdon R, Dillon L, Adams L, Kelly C, Zhang J, Wexler J, Green E, Good P, Feingold E, Bernstein B, Birney E, Crawford G, Dekker J, Elnitski L, Farnham P, Gerstein M, Giddings M, Gingeras T, Green E, Guigó R, Hardison R, Hubbard T, Kellis M, Kent W, Lieb J, Margulies E, Myers R, Snyder M, Stamatoyannopoulos J, Tenenbaum S, Weng Z, White K, Wold B, Khatun J, Yu Y, Wrobel J, Risk B, Gunawardena H, Kuiper H, Maier C, Xie L, Chen X, Giddings M, Bernstein B, Epstein C, Shoresh N, Ernst J, Kheradpour P, Mikkelsen T, Gillespie S, Goren A, Ram O, Zhang X, Wang L, Issner R, Coyne M, Durham T, Ku M, Truong T, Ward L, Altshuler R, Eaton M, Kellis M, Djebali S, Davis C, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov G, Khatun J, Williams B, Zaleski C, Rozowsky J, Röder M, Kokocinski F, Abdelhamid R, Alioto T, Antoshechkin I, Baer M, Batut P, Bell I, Bell K, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood M, Gao H, Gonzalez D, Gordon A, Gunawardena H, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Li G, Luo O, Park E, Preall J, Presaud K, Ribeca P, Risk B, Robyr D, Ruan X, Sammeth M, Sandhu K, Schaeffer L, See L, Shahab A, Skancke J, Suzuki A, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Hayashizaki Y, Harrow J, Gerstein M, Hubbard T, Reymond A, Antonarakis S, Hannon G, Giddings M, Ruan Y, Wold B, Carninci P, Guigó R, Gingeras T, Rosenbloom K, Sloan C, Learned K, Malladi V, Wong M, Barber G, Cline M, Dreszer T, Heitner S, Karolchik D, Kent W, Kirkup V, Meyer L, Long J, Maddren M, Raney B, Furey T, Song L, Grasfeder L, Giresi P, Lee B, Battenhouse A, Sheffield N, Simon J, Showers K, Safi A, London D, Bhinge A, Shestak C, Schaner M, Ki Kim S, Zhang Z, Mieczkowski P, Mieczkowska J, Liu Z, McDaniell R, Ni Y, Rashid N, Kim M, Adar S, Zhang Z, Wang T, Winter D, Keefe D, Birney E, Iyer V, Lieb J, Crawford G, Li G, Sandhu K, Zheng M, Wang P, Luo O, Shahab A, Fullwood M, Ruan X, Ruan Y, Myers R, Pauli F, Williams B, Gertz J, Marinov G, Reddy T, Vielmetter J, Partridge E, Trout D, Varley K, Gasper C, Bansal A, Pepke S, Jain P, Amrhein H, Bowling K, Anaya M, Cross M, King B, Muratet M, Antoshechkin I, Newberry K, McCue K, Nesmith A, Fisher-Aylor K, Pusey B, DeSalvo G, Parker S, Balasubramanian S, Davis N, Meadows S, Eggleston T, Gunter C, Newberry J, Levy S, Absher D, Mortazavi A, Wong W, Wold B, Blow M, Visel A, Pennachio L, Elnitski L, Margulies E, Parker S, Petrykowska H, Abyzov A, Aken B, Barrell D, Barson G, Berry A, Bignell A, Boychenko V, Bussotti G, Chrast J, Davidson C, Derrien T, Despacio-Reyes G, Diekhans M, Ezkurdia I, Frankish A, Gilbert J, Gonzalez J, Griffiths E, Harte R, Hendrix D, Howald C, Hunt T, Jungreis I, Kay M, Khurana E, Kokocinski F, Leng J, Lin M, Loveland J, Lu Z, Manthravadi D, Mariotti M, Mudge J, Mukherjee G, Notredame C, Pei B, Rodriguez J, Saunders G, Sboner A, Searle S, Sisu C, Snow C, Steward C, Tanzer A, Tapanari E, Tress M, van Baren M, Walters N, Washietl S, Wilming L, Zadissa A, Zhang Z, Brent M, Haussler D, Kellis M, Valencia A, Gerstein M, Reymond A, Guigó R, Harrow J, Hubbard T, Landt S, Frietze S, Abyzov A, Addleman N, Alexander R, Auerbach R, Balasubramanian S, Bettinger K, Bhardwaj N, Boyle A, Cao A, Cayting P, Charos A, Cheng Y, Cheng C, Eastman C, Euskirchen G, Fleming J, Grubert F, Habegger L, Hariharan M, Harmanci A, Iyengar S, Jin V, Karczewski K, Kasowski M, Lacroute P, Lam H, Lamarre-Vincent N, Leng J, Lian J, Lindahl-Allen M, Min R, Miotto B, Monahan H, Moqtaderi Z, Mu X, O’Geen H, Ouyang Z, Patacsil D, Pei B, Raha D, Ramirez L, Reed B, Rozowsky J, Sboner A, Shi M, Sisu C, Slifer T, Witt H, Wu L, Xu X, Yan K, Yang X, Yip K, Zhang Z, Struhl K, Weissman S, Gerstein M, Farnham P, Snyder M, Tenenbaum S, Penalva L, Doyle F, Karmakar S, Landt S, Bhanvadia R, Choudhury A, Domanus M, Ma L, Moran J, Patacsil D, Slifer T, Victorsen A, Yang X, Snyder M, White K, Auer T, Centanin L, Eichenlaub M, Gruhl F, Heermann S, Hoeckendorf B, Inoue D, Kellner T, Kirchmaier S, Mueller C, Reinhardt R, Schertel L, Schneider S, Sinn R, Wittbrodt B, Wittbrodt J, Weng Z, Whitfield T, Wang J, Collins P, Aldred S, Trinklein N, Partridge E, Myers R, Dekker J, Jain G, Lajoie B, Sanyal A, Balasundaram G, Bates D, Byron R, Canfield T, Diegel M, Dunn D, Ebersol A, Frum T, Garg K, Gist E, Hansen R, Boatman L, Haugen E, Humbert R, Jain G, Johnson A, Johnson E, Kutyavin T, Lajoie B, Lee K, Lotakis D, Maurano M, Neph S, Neri F, Nguyen E, Qu H, Reynolds A, Roach V, Rynes E, Sabo P, Sanchez M, Sandstrom R, Sanyal A, Shafer A, Stergachis A, Thomas S, Thurman R, Vernot B, Vierstra J, Vong S, Wang H, Weaver M, Yan Y, Zhang M, Akey J, Bender M, Dorschner M, Groudine M, MacCoss M, Navas P, Stamatoyannopoulos G, Kaul R, Dekker J, Stamatoyannopoulos J, Dunham I, Beal K, Brazma A, Flicek P, Herrero J, Johnson N, Keefe D, Lukk M, Luscombe N, Sobral D, Vaquerizas J, Wilder S, Batzoglou S, Sidow A, Hussami N, Kyriazopoulou-Panagiotopoulou S, Libbrecht M, Schaub M, Kundaje A, Hardison R, Miller W, Giardine B, Harris R, Wu W, Bickel P, Banfai B, Boley N, Brown J, Huang H, Li Q, Li J, Noble W, Bilmes J, Buske O, Hoffman M, Sahu A, Kharchenko P, Park P, Baker D, Taylor J, Weng Z, Iyer S, Dong X, Greven M, Lin X, Wang J, Xi H, Zhuang J, Gerstein M, Alexander R, Balasubramanian S, Cheng C, Harmanci A, Lochovsky L, Min R, Mu X, Rozowsky J, Yan K, Yip K, Birney E. An integrated encyclopedia of DNA elements in the human genome. Nature 2012, 489: 57-74. PMID: 22955616, PMCID: PMC3439153, DOI: 10.1038/nature11247.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsBinding SitesChromatinChromatin ImmunoprecipitationChromosomes, HumanDeoxyribonuclease IDNADNA FootprintingDNA MethylationDNA-Binding ProteinsEncyclopedias as TopicExonsGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenome, HumanGenomicsHistonesHumansMammalsMolecular Sequence AnnotationNeoplasmsPolymorphism, Single NucleotidePromoter Regions, GeneticProteinsRegulatory Sequences, Nucleic AcidSequence Analysis, RNATranscription FactorsTranscription, GeneticConceptsHuman genomeRegions of transcriptionTranscription factor associationDNA Elements (ENCODE) projectProtein-coding regionsBlueprint of lifeCandidate regulatory elementsChromatin structureHistone modificationsGene regulationFunctional annotationDNA elementsBiochemical functionsNew insightsRegulatory elementsGenomeHuman diseasesExpansive resourceGenesEncyclopediaRegulationBiomedical researchTranscriptionAnnotationInsights
2011
Translational bioinformatics: linking knowledge across biological and clinical realms
Sarkar I, Butte A, Lussier Y, Tarczy-Hornoch P, Ohno-Machado L. Translational bioinformatics: linking knowledge across biological and clinical realms. Journal Of The American Medical Informatics Association 2011, 18: 354-357. PMID: 21561873, PMCID: PMC3128415, DOI: 10.1136/amiajnl-2011-000245.Commentaries, Editorials and Letters
2010
Insight-Related Challenges in the Treatment of Hoarding
Frost R, Tolin D, Maltby N. Insight-Related Challenges in the Treatment of Hoarding. Cognitive And Behavioral Practice 2010, 17: 404-413. DOI: 10.1016/j.cbpra.2009.07.004.Peer-Reviewed Original ResearchTGF-beta1 interactome: metastasis and beyond.
Perera M, Tsang C, Distel R, Lacy J, Ohno-Machado L, Ricchiuti V, Samaranayake L, Smejkal G, Smith M, Trachtenberg A, Kuo W. TGF-beta1 interactome: metastasis and beyond. Cancer Genomics & Proteomics 2010, 7: 217-29. PMID: 20656987.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferential expression profilesCancer therapeuticsPersonalized cancer therapeuticsRegulation of tumorEffective cancer therapeuticsNovel cancer biomarkersGenomic dataExpression profilesMetastatic attributesInteractomeUbiquitous cytokineTumor progressionCancer biomarkersPolarity changeTherapeuticsValuable insightsImmense valueRegulationInsightsInducerImportant stepMappingGrowth
2006
Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights
Kim PM, Lu LJ, Xia Y, Gerstein MB. Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights. Science 2006, 314: 1938-1941. PMID: 17185604, DOI: 10.1126/science.1136174.Peer-Reviewed Original Research
1997
Inherited metabolic disease
Schilsky M. Inherited metabolic disease. Current Opinion In Gastroenterology 1997, 13: 194-198. DOI: 10.1097/00001574-199705000-00004.Peer-Reviewed Original ResearchMutant proteinsNew insightsPathobiology of diseaseGene productsQuality control systemProtein productionMolecular studiesNew therapeutic treatmentsMolecular interactionsGenesPhysiologic functionGenetic hemochromatosisMetabolic diseasesNormal physiologic functionWilson's diseaseDiscoveryProteinCellular elementsInsightsTherapeutic treatmentBasic understandingAntitrypsin deficiencyMetabolic disordersAnimal modelsDisease
1992
Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging
Bucala R, Cerami A. Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging. Advances In Pharmacology 1992, 23: 1-34. PMID: 1540533, DOI: 10.1016/s1054-3589(08)60961-8.Peer-Reviewed Original ResearchConceptsBiological processesGlycosylation processGlycosylation mechanismsBiochemical basisRelated pathwaysAge-related processesBiologyPathological processesGlycosylation productsDiverse effectsStructural elucidationAdvanced glycosylation productsCell-mediated processGlycosylationInsightsPathwayBiochemistryElucidationMaillard reactionAccumulationVivoLarge partMultiorgan pathology
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