2022
The role of PI3Kγ in the immune system: new insights and translational implications
Lanahan SM, Wymann MP, Lucas CL. The role of PI3Kγ in the immune system: new insights and translational implications. Nature Reviews Immunology 2022, 22: 687-700. PMID: 35322259, PMCID: PMC9922156, DOI: 10.1038/s41577-022-00701-8.Peer-Reviewed Original ResearchConceptsProtein structure determinationContext-dependent modulatorNew insightsImmune systemMonogenic immune disordersSpecific PI3Kγ inhibitorInflammatory cytokine releaseRole of PI3KγPI3Kγ deficiencyImmunomodulatory roleCytokine releaseClinical trialsImmune disordersPI3KγTherapeutic targetOncology indicationsTranslational implicationsDrug developmentStructure determinationPI3Kγ inhibitorsRecent advancesPhosphoinositideRoleHumansInsights
2021
Maximizing insights from monogenic immune disorders
Barmada A, Ramaswamy A, Lucas CL. Maximizing insights from monogenic immune disorders. Current Opinion In Immunology 2021, 73: 50-57. PMID: 34695727, PMCID: PMC8915947, DOI: 10.1016/j.coi.2021.09.008.Peer-Reviewed Original ResearchConceptsDisease gene discoveryGene discoverySingle geneIntegrative omicsMonogenic immune disordersHuman diseasesUnprecedented insightsMouse modelingFundamental immune functionsImmune disordersMechanistic studiesGenomeGenomicsImmune functionOmicsDisease discoveryDiscoveryGenesInsightsDisordersDisease
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