2016
Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification
Lin T, Wang XL, Zettervall SL, Cai Y, Guzman RJ. Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification. Journal Of Vascular Surgery 2016, 66: 586-593. PMID: 27374065, PMCID: PMC5201454, DOI: 10.1016/j.jvs.2016.03.462.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicAortic DiseasesBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCells, CulturedHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleOrgan Culture TechniquesOsteogenesisPhosphatesPyrazolesQuinolinesRats, Sprague-DawleySignal TransductionVascular CalcificationConceptsMedial artery calcificationSmooth muscle cellsArtery calcificationMedial calcificationOrgan culture modelVascular patientsVascular calcificationWestern blotCalcium accumulationHuman aortic smooth muscle cellsChronic kidney diseaseCulture modelVascular smooth muscle cellsAortic smooth muscle cellsQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionSMC markersTranscription-polymerase chain reactionHuman smooth muscle cellsAortic medial calcificationMuscle myosin heavy chainHomologue 1Bone morphogenetic proteinKidney diseasePolymerase chain reaction
2006
Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages
Tircol M, Tirziu D, Simionescu M. Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages. Open Life Sciences 2006, 1: 150-166. DOI: 10.2478/s11535-006-0010-x.Peer-Reviewed Original ResearchSmooth muscle cellsLipid accumulationMuscle cellsHuman aortic smooth muscle cellsCultured smooth muscle cellsAortic smooth muscle cellsGene expressionLysosomal degradationLDL receptorCellular degradationMatrix proteinsAcidic compartmentsCellular uptakeLysosomal compartmentCell typesFluorescence microscopyLDL inducesUndegraded formCholesterol ester synthesisRT-PCRCholesteryl ester synthesisNative LDLAccumulationRegulationRegulation of LDL
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