2010
Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice
Stabile LP, Rothstein ME, Keohavong P, Lenzner D, Land SR, Gaither-Davis AL, Kim KJ, Kaminski N, Siegfried JM. Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice. Cancers 2010, 2: 2153-2170. PMID: 21390244, PMCID: PMC3049550, DOI: 10.3390/cancers2042153.Peer-Reviewed Original ResearchHepatocyte growth factorLung cancerC-MetLung tumorigenesisAdditive anti-tumor effectsSmall molecule c-Met inhibitorsNon-small cell lung cancer cellsCell lung cancer cellsK-ras mutation rateHGF/c-MetLung cancer casesHuman hepatocyte growth factorAnti-tumor effectsLung cancer cellsEGFR inhibitor gefitinibSimilar downstream signalingC-Met inhibitorsAirway expressionSingle blockadeDual blockadeTumor numberClinical benefitTobacco carcinogensCancer casesLung tumors
2001
Ductular morphogenesis and functional polarization of normal human biliary epithelial cells in three-dimensional culture
Ishida Y, Smith S, Wallace L, Sadamoto T, Okamoto M, Auth M, Strazzabosco M, Fabris L, Medina J, Prieto J, Strain A, Neuberger J, Joplin R. Ductular morphogenesis and functional polarization of normal human biliary epithelial cells in three-dimensional culture. Journal Of Hepatology 2001, 35: 2-9. PMID: 11495037, DOI: 10.1016/s0168-8278(01)00078-2.Peer-Reviewed Original ResearchConceptsCollagen gel cultureHuman biliary epithelial cellsEpithelial cellsGel cultureGrowth factorHuman hepatocyte growth factorThree-dimensional cultureBiliary epithelial cellsThree-dimensional aggregatesNormal human biliary epithelial cellsFoetal bovine serumMorphogenesisCell typesAnion exchanger 2Hepatocyte growth factorFunctional polarizationFunctional differentiationFunctional markersExchanger 2Monolayer culture systemCentral lumenPhenotypic markersCollagen gelsNumber of aggregatesCulture system
1997
Na+‐dependent and ‐independent Cl−/HCO exchange mediate cellular HCO transport in cultured human intrahepatic bile duct cells
Strazzabosco M, Joplin R, Zsembery A, Wallace L, Spirli C, Fabris L, Granato A, Rossanese A, Poci C, Neuberger J, Okolicsanyi L, Crepaldi G. Na+‐dependent and ‐independent Cl−/HCO exchange mediate cellular HCO transport in cultured human intrahepatic bile duct cells. Hepatology 1997, 25: 976-985. PMID: 9096607, DOI: 10.1002/hep.510250431.Peer-Reviewed Original ResearchConceptsEpithelial membrane antigenIntracellular acid loadHuman cholangiocytesAcid loadIntrahepatic bile duct cellsFactor VIII-related antigenIntracellular cyclic adenosine monophosphate (cAMP) concentrationsBiliary HCO3- secretionPediatric liver transplantationAdministration of agentsCyclic adenosine monophosphate concentrationsHuman hepatocyte growth factorVIII-related antigenBile duct cellsNormal liver tissueBiliary epithelial cellsCl- channel inhibitorsHepatocyte growth factorAdenosine monophosphate concentrationsIntracellular cAMP concentrationLiver transplantationReduced graftAbsence of HCO3Biliary treeAcid loader
1992
Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.
Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan M, Zarnegar R. Scatter factor and hepatocyte growth factor: activities, properties, and mechanism. Molecular Cancer Research 1992, 3: 11-20. PMID: 1534687.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorScatter factorPartial amino acid sequence dataAmino acid sequence dataAmino acid sequenceFibroblast-derived proteinHuman smooth muscle cellsVascular endothelial cell typesEndothelial cell typesGrowth factorSignificant homologyPosttranslational modificationsSequence dataRapid phosphorylationAcid sequenceBiological activityTyrosine residuesProtein productsCohesive coloniesCommon antigenic determinantsCell typesSpecies-related differencesProteinSerum-derived proteinsHuman hepatocyte growth factor
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