2025
More than taking a pill: the effects of intersectional microaggressions on pre-exposure prophylaxis adherence among Black MSM
Whitfield D, Mammadli T, Gordon J, Dācus J, Chandler C, Turpin R, Douaihy A. More than taking a pill: the effects of intersectional microaggressions on pre-exposure prophylaxis adherence among Black MSM. Journal Of HIV/AIDS & Social Services 2025, ahead-of-print: 1-14. DOI: 10.1080/15381501.2025.2517604.Peer-Reviewed Original ResearchBlack MSMPrEP adherenceLevels of PrEP adherencePre-exposure prophylaxis adherenceAdaptive coping skillsIntersectional microaggressionsDistress scoresBlack menCoping skillsMicroaggressionsAdherence level groupsMSMProphylaxis adherencePrEPSignificant stressorsAdherenceKruskal-Wallis testPilot studyLevel groupKruskal-WallisScoresMenDistressParticipantsImplementing a pre-exposure prophylaxis (PrEP) promotion intervention among persons who inject drugs: Perspectives from community and research implementation partners
Warnock C, Mistler C, Viera A, Harsono D, Weiss J, Davidson D, Bailey G, Buchelli M, Eggert K, Rose R, Montgomery J, Robinson P, Rojas Perez O, Pickering E, Rash C, Edelman E. Implementing a pre-exposure prophylaxis (PrEP) promotion intervention among persons who inject drugs: Perspectives from community and research implementation partners. Journal Of Substance Use And Addiction Treatment 2025, 172: 209667. PMID: 40057242, PMCID: PMC12009193, DOI: 10.1016/j.josat.2025.209667.Peer-Reviewed Original ResearchCommunity-based settingsFocus group participantsOff-site servicesPre-exposure prophylaxisPromotion interventionsGroup participantsSite leadershipImplementing HIV prevention interventionsImplementing partnersContingency managementParticipants identified barriersEvidence-based interventionsHIV prevention interventionsQualitative data collectionImplementation facilitatorsPromotion programsStepped careTeam presenceHealth servicesPromote PrEPCommunity settingsPreventive interventionsIntervention activitiesResearch implementationPrEP adherence
2024
Prepare Romania: study protocol for a randomized controlled trial of an intervention to promote pre-exposure prophylaxis adherence and persistence among gay, bisexual, and other men who have sex with men
Lelutiu-Weinberger C, Filimon M, Zavodszky A, Lixandru M, Hanu L, Fierbinteanu C, Patrascu R, Streinu-Cercel A, Luculescu S, Bora M, Filipescu I, Jianu C, Heightow-Weidman L, Rochelle A, Yi B, Buckner N, Golub S, van Dyk I, Burger J, Li F, Pachankis J. Prepare Romania: study protocol for a randomized controlled trial of an intervention to promote pre-exposure prophylaxis adherence and persistence among gay, bisexual, and other men who have sex with men. Trials 2024, 25: 470. PMID: 38987812, PMCID: PMC11238350, DOI: 10.1186/s13063-024-08313-4.Peer-Reviewed Original ResearchConceptsGBMSM livingPrEP adherenceRandomized controlled trial designMobile health interventionsRollout of PrEPMonths post-randomizationPre-exposure prophylaxisPre-exposure prophylaxis adherenceSelf-report surveyRandomized Controlled TrialsPromotion interventionsPrescribed PrEPEfficacy of toolsHealth interventionsNational rolloutHealth systemPrEP rolloutDiscussionThe knowledgeIntervention efficacyEffectiveness trialBlood spot testingPost-randomizationHigh-risk groupHIV transmissionDried blood spot testingDemonstrating service delivery models for effective initiation and retention on pre-exposure prophylaxis (PrEP) among female bar workers in Dar es Salaam, Tanzania: A double randomized intervention study protocol
Chebet J, Akyoo W, Goymann H, Harling G, Barnhart D, Mosha I, Kamori D, Gandhi M, Mbunda T, Kipeleka J, Sando D, Spiegelman D, Mpembeni R, Bärnighausen T. Demonstrating service delivery models for effective initiation and retention on pre-exposure prophylaxis (PrEP) among female bar workers in Dar es Salaam, Tanzania: A double randomized intervention study protocol. PLOS ONE 2024, 19: e0304077. PMID: 38935796, PMCID: PMC11210872, DOI: 10.1371/journal.pone.0304077.Peer-Reviewed Original ResearchConceptsFemale bar workersPre-exposure prophylaxisIntention-to-treatBar workersPrimary outcomeRisk of HIV infectionAdherence to PrEPRisk of HIV acquisitionImprove PrEP adherenceGerman Clinical Trials RegisterPublic sector clinicsService delivery modelsRandomized trial designHIV negative womenPrevent HIV InfectionHIV infectionPrEP provisionClinical Trials RegisterHIV testingPrEP initiationHealth facilitiesPromote PrEPPrEP adherenceDelivery modelsReduce barriers
2023
Perspectives on unhealthy alcohol use among men who have sex with men prescribed HIV pre-exposure prophylaxis: A qualitative study
Strong S, Oldfield B, van den Berg J, Cole C, Biegacki E, Ogbuagu O, Virata M, Chan P, Edelman E. Perspectives on unhealthy alcohol use among men who have sex with men prescribed HIV pre-exposure prophylaxis: A qualitative study. Preventive Medicine Reports 2023, 37: 102553. PMID: 38282665, PMCID: PMC10810836, DOI: 10.1016/j.pmedr.2023.102553.Peer-Reviewed Original ResearchUnhealthy alcohol usePre-exposure prophylaxisAlcohol reduction interventionsAlcohol useHIV pre-exposure prophylaxisOral pre-exposure prophylaxisAcquisition of HIVAlcohol-related harmPrEP adherencePrEP careTreatment optionsOral formulationReduction interventionsPrEP programMSMPrEPProphylaxisHIVMultimodal approachMenCareAdherenceInterventionSexUnited StatesApplication of the multiphase optimisation strategy (MOST) to optimise HIV prevention targeting people on medication for opioid use disorder (MOUD) who have cognitive dysfunction: protocol for a MOST study
Mistler C, Shrestha R, Gunstad J, Collins L, Madden L, Huedo-Medina T, Sibilio B, Copenhaver N, Copenhaver M. Application of the multiphase optimisation strategy (MOST) to optimise HIV prevention targeting people on medication for opioid use disorder (MOUD) who have cognitive dysfunction: protocol for a MOST study. BMJ Open 2023, 13: e071688. PMID: 37399447, PMCID: PMC10314648, DOI: 10.1136/bmjopen-2023-071688.Peer-Reviewed Original ResearchConceptsOpioid use disorderMultiphase optimization strategyCognitive dysfunctionHIV preventionUse disordersPromising biomedical interventionsPre-exposure prophylaxisHIV incidence ratesHIV risk reductionHIV prevention interventionsDrug treatment settingsInstitutional review boardInformed consent formPrEP adherenceHIV prevention contentHIV infectionPrEP uptakeStudy protocolIncidence rateRisk groupsPrevention interventionsPWIDTreatment settingsReview boardEffective interventions
2022
Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs
Sung M, Viera A, Esserman D, Tong G, Davidson D, Aiudi S, Bailey G, Buchanan A, Buchelli M, Jenkins M, John B, Kolakowski J, Lame A, Murphy S, Porter E, Simone L, Paris M, Rash C, Edelman E. Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs. Contemporary Clinical Trials 2022, 125: 107037. PMID: 36460267, PMCID: PMC9918697, DOI: 10.1016/j.cct.2022.107037.Peer-Reviewed Original ResearchConceptsAdherence support servicesHIV risk reductionPrEP adherenceContingency managementHybrid type 1 effectiveness-implementation trialHIV pre-exposure prophylaxisEffectiveness-implementation studyPre-exposure prophylaxisEffectiveness-implementation trialOpioid use disorderStrengths-based case managementRisk reductionSupport servicesCommunity-based programsPrEP initiationPrimary outcomeWeek 12Clinical trialsHIV preventionUse disordersCM sessionsCase managementBlood spotsPWIDStudy designClient-Centered Care Coordination (C4™) for HIV/STI Prevention: a Theoretical, Conceptual, and Methodological Overview—HIV Prevention Trials Network (HPTN) 073
Nelson L, Wilton L, Whitfield D, Williams G, Mayer K, Komárek A, Boyd D, Beauchamp G, Fields S, Wheeler D. Client-Centered Care Coordination (C4™) for HIV/STI Prevention: a Theoretical, Conceptual, and Methodological Overview—HIV Prevention Trials Network (HPTN) 073. Sexuality Research And Social Policy 2022, 19: 1365-1382. PMID: 39301523, PMCID: PMC11412310, DOI: 10.1007/s13178-022-00687-x.Peer-Reviewed Original ResearchBlack MSMPrEP useHIV/STI preventionCare coordination encountersUse of PrEPPrevention of HIVPrevention demonstration projectTwelve-month retentionMulti-component interventionHealth policy effortsEvidence-based strategiesPrEP adherencePrEP formulationsOral regimensPrEP servicesAdherence goalsSTI preventionPrEP usersPublic health policy effortsCare coordinationStudy visitRisk counselingSexual healthProgram retentionMSM
2020
A Review of Pre-Exposure Prophylaxis Adherence among Female Sex Workers
Ghayda R, Hong S, Yang J, Jeong G, Lee K, Kronbichler A, Solmi M, Stubbs B, Koyanagi A, Jacob L, Oh H, Kim J, Shin J, Smith L. A Review of Pre-Exposure Prophylaxis Adherence among Female Sex Workers. Yonsei Medical Journal 2020, 61: 349-358. PMID: 32390358, PMCID: PMC7214109, DOI: 10.3349/ymj.2020.61.5.349.Peer-Reviewed Original ResearchConceptsFemale sex workersPromote PrEP adherencePrEP adherenceHuman immunodeficiency virusIntervention programsStigma associated with sex workIntegration of PrEPPrimary care visitsSex workersRisk of contracting human immunodeficiency virusPublic health policiesPre-exposure prophylaxisHuman immunodeficiency virus epidemicPrevent HIV InfectionCare visitsMultidisciplinary interventionPrEP useHIV PrEPHealth policyLifestyle modificationPrEPHuman immunodeficiency virus controlEducational effortsPrEP efficacyProphylaxis adherenceFeasibility and Acceptability of an mHealth-Based Approach as an HIV Prevention Strategy Among People Who Use Drugs on Pre-Exposure Prophylaxis
Shrestha R, Altice FL, DiDomizio E, Sibilio B, Ranjit YS, Copenhaver MM. Feasibility and Acceptability of an mHealth-Based Approach as an HIV Prevention Strategy Among People Who Use Drugs on Pre-Exposure Prophylaxis. Patient Preference And Adherence 2020, 14: 107-118. PMID: 32021122, PMCID: PMC6971384, DOI: 10.2147/ppa.s236794.Peer-Reviewed Original ResearchPre-exposure prophylaxisHIV risk reductionHIV preventionText messaging servicePrimary HIV preventionHIV prevention strategiesOpioid-dependent peopleReminder text messagesWeekly text messagesPost-intervention assessmentRisk reductionForty HIVPrEP adherenceText messagesSMS remindersRisk groupsText remindersPrevention strategiesUnderserved populationsMHealth technologiesAcceptability studyHealth carePreventionProphylaxisPreliminary evidence
2019
Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study
Shrestha R, Altice FL, Sibilio B, Ssenyonjo J, Copenhaver MM. Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study. Contemporary Clinical Trials 2019, 82: 77-84. PMID: 31229618, PMCID: PMC6639056, DOI: 10.1016/j.cct.2019.06.012.Peer-Reviewed Original ResearchConceptsBio-behavioral interventionHIV risk reductionOpioid-dependent peopleMethadone maintenance programPrEP adherenceHIV transmission risk reductionFirst prospective trialPre-exposure prophylaxisHIV prevention strategiesOngoing drug useRisk reductionBehavioral skills modelProspective trialSecondary outcomesPrimary outcomeRisk reduction outcomesHIV riskWeek 20Prevention strategiesUnmet needDrug useHybrid type IBio-behavioral approachProcess evaluationAdherence
2018
Exploring the Use of Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among High-Risk People Who Use Drugs in Treatment
Shrestha R, Copenhaver M. Exploring the Use of Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among High-Risk People Who Use Drugs in Treatment. Frontiers In Public Health 2018, 6: 195. PMID: 30062091, PMCID: PMC6054971, DOI: 10.3389/fpubh.2018.00195.Peer-Reviewed Original ResearchPre-exposure prophylaxisPrEP adherenceHIV preventionHigh-risk PWUDSubstance abuse treatment settingsUse of PrEPHigh-risk peopleHIV risk behaviorsHIV prevention approachesPrEP servicesDaily dosingPrEP useHigh adherenceDepth semi-structured qualitative interviewsSemi-structured qualitative interviewsTreatment settingsPocket costsRisk behaviorsDisclosure statusPrEPAdherencePrevention approachesProphylaxisPreliminary evidencePWUDIntegrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study
Shrestha R, Altice FL, Karki P, Copenhaver MM. Integrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study. AIDS And Behavior 2018, 22: 2640-2649. PMID: 29582199, PMCID: PMC6051885, DOI: 10.1007/s10461-018-2099-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidBiobehavioral SciencesCondomsFeasibility StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMethadoneMiddle AgedMotivationOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CarePilot ProjectsPre-Exposure ProphylaxisProspective StudiesRisk Reduction BehaviorSexual BehaviorSexual PartnersSubstance Abuse, IntravenousConceptsPre-exposure prophylaxis adherenceSelf-reported PrEP adherenceSex-related risk behaviorsHIV risk reduction behaviorsBio-behavioral interventionPre-exposure prophylaxisProspective clinical trialsHigh-risk peopleHIV prevention interventionsHIV risk behaviorsPilot feasibility studyPost-intervention assessmentPrEP adherenceProphylaxis adherencePreliminary efficacyClinical trialsIntervention groupHIV riskPrevention interventionsRisk behaviorsBio-behavioral approachAdherenceInterventionHigh acceptabilityPrEP
2017
Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research
Shrestha R, Altice F, Karki P, Copenhaver M. Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research. Frontiers In Immunology 2017, 8: 561. PMID: 28553295, PMCID: PMC5425476, DOI: 10.3389/fimmu.2017.00561.Peer-Reviewed Original ResearchNeurocognitive impairmentHigh-risk drug usersBehavioral interventionsHigh-risk PWUDHIV prevention behavioral interventionBiobehavioral approachHIV risk reductionHIV prevention interventionsDrug treatment settingsFormative researchHIV prevention effortsTarget populationPrEP adherencePrEP uptakeRisk reduction outcomesHIV preventionDrug treatmentPrevention interventionsFocus groupsTreatment settingsDrug usersRecovery programStructured focus groupsRisk behaviorsTarget population members
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