2021
Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies
Yi Z, Salem F, Menon MC, Keung K, Xi C, Hultin S, Haroon Al Rasheed MR, Li L, Su F, Sun Z, Wei C, Huang W, Fredericks S, Lin Q, Banu K, Wong G, Rogers NM, Farouk S, Cravedi P, Shingde M, Smith RN, Rosales IA, O'Connell PJ, Colvin RB, Murphy B, Zhang W. Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies. Kidney International 2021, 101: 288-298. PMID: 34757124, PMCID: PMC10285669, DOI: 10.1016/j.kint.2021.09.028.Peer-Reviewed Original ResearchConceptsGraft lossTransplant biopsiesDamage scoreBanff scoresPathological lesionsOne-year graft lossPost-transplant graft lossGlomerular filtration rate declineIntermediate-risk groupKidney allograft failurePost-transplant biopsiesKidney transplant biopsiesMononuclear leukocyte infiltrationTissue compartmentsMononuclear leukocyte infiltrateProtocol biopsiesAllograft failureTransplant recipientsClinical predictorsTubular atrophyGraft damageRisk stratificationInterstitial fibrosisLeukocyte infiltrationLeukocyte infiltrate
2014
Electron Microscopy Contribution to Diagnosing Transplant Glomerulopathy: A Single-Center Experience
Rigo D, Barrón MB, Martinatto C, Mukdsi J, Orías M, Novoa P. Electron Microscopy Contribution to Diagnosing Transplant Glomerulopathy: A Single-Center Experience. Transplantation Proceedings 2014, 46: 2975-2980. PMID: 25420804, DOI: 10.1016/j.transproceed.2014.07.008.Peer-Reviewed Original ResearchConceptsInterstitial fibrosis/tubular atrophyDeceased donor renal transplantLower graft survivalPercent of patientsKidney transplant biopsiesSingle-center experienceIdentification of patientsGraft dysfunctionGraft survivalRenal transplantTransplant biopsiesTransplant glomerulopathyGraft pathologyTubular atrophyStudy criteriaHistologic changesPatientsAverage evolution timeEarly changesAccurate diagnosisLight microscopyTransplantation timeBiopsyDiagnosisTransplantation
1976
Kidney transplant biopsies in the diagnosis and management of acute rejection reactions
Finkelstein F, Siegel N, Bastl C, Forrest J, Kashgarian M. Kidney transplant biopsies in the diagnosis and management of acute rejection reactions. Kidney International 1976, 10: 171-178. PMID: 787617, DOI: 10.1038/ki.1976.92.Peer-Reviewed Original ResearchConceptsAcute clinical rejectionTime of biopsyClinical rejectionAcute rejectionTransplant biopsiesGraft recipientsClinical statusRejection reactionAcute rejection reactionGlomerular endothelial swellingStandard immunosuppressive treatmentInstitution of treatmentKidney transplant biopsiesRenal transplant biopsiesHistopathologic categorizationImmunosuppressive treatmentClinical responseRenal functionEndothelial swellingHistologic featuresEndothelial edemaHistopathologic changesInterstitial edemaClinical dataRetrospective analysis
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