2020
Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets
Achanta S, Jordt S. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. Annals Of The New York Academy Of Sciences 2020, 1480: 73-103. PMID: 32892378, PMCID: PMC7933981, DOI: 10.1111/nyas.14472.Peer-Reviewed Original ResearchConceptsChemical injuryTRP channelsNeurogenic inflammatory pathwaysChemical threat agentsMediator of injuryTransient receptor potential channelsTransient receptor potential (TRP) ion channelsIntracellular calcium levelsToxic inhalation hazardPotential ion channelsCough reflexPulmonary injuryPulmonary edemaProinflammatory cellsInflammatory pathwaysPathophysiologic eventsOccupational exposureMucus clearanceCalcium levelsInjuryNonneuronal pathwaysRespiratory systemBroader indicationsPotential channelsInhalation hazard
2014
Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS
Hadzipasic M, Tahvildari B, Nagy M, Bian M, Horwich AL, McCormick DA. Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 16883-16888. PMID: 25385594, PMCID: PMC4250117, DOI: 10.1073/pnas.1419497111.Peer-Reviewed Original ResearchConceptsMN cell bodiesMotor neuronsMo of ageCell bodiesSpinal cordSpinal cord tissue slicesWhole-cell patch-clamp recordingsCell patch-clamp recordingsAdult mouse spinal cordIntrinsic electrophysiologic propertiesTwitch muscleSpinal motor neuronsLower extremity musclesTransgenic mouse modelMouse motor neuronsPatch-clamp recordingsAmyotrophic lateral sclerosisMouse spinal cordSlow-twitch muscleSteady-state firing ratePhysiological subtypesRetrograde tracingAcute slicesExtremity musclesPathophysiologic events
2004
Pathophysiology and pharmacologic treatment of acute spinal cord injury
Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. The Spine Journal 2004, 4: 451-464. PMID: 15246307, DOI: 10.1016/j.spinee.2003.07.007.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryPathophysiologic processesPharmacologic treatmentNeuroprotective agentsSecondary damageImportant pathophysiologic processSecondary injury cascadePharmacologic therapyAcute treatmentInjury cascadeNeurologic functionNeuroprotective strategiesDevastating injuriesPathophysiologic mechanismsSpecific therapyPathophysiologic eventsSpinal cordHuman trialsPotential therapyInjuryAnimal dataLiterature reviewTherapy
1994
Why Should Sleep Apnea Be Diagnosed and Treated?
Yamashiro Y, Kryger M. Why Should Sleep Apnea Be Diagnosed and Treated? Clinical Pulmonary Medicine 1994, 1: 250-259. DOI: 10.1097/00045413-199407000-00007.Peer-Reviewed Original ResearchNasal continuous positive airway pressureObstructive sleep apneaSevere sequelaeRepetitive upper airway obstructionsContinuous positive airway pressureUpper airway obstructionPositive airway pressureTreatment of choiceGoal of treatmentPrimary pathophysiologic eventEffect of treatmentAirway obstructionAirway pressureSevere complicationsPatients' qualitySleep apneaMultisystem dysfunctionPathophysiologic eventsCommon disorderUndiagnosed patientsSevere casesSequelaePatient's lifeApneaPatients
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