2024
A High-Quality Blue Whale Genome, Segmental Duplications, and Historical Demography
Bukhman Y, Morin P, Meyer S, Chu L, Jacobsen J, Antosiewicz-Bourget J, Mamott D, Gonzales M, Argus C, Bolin J, Berres M, Fedrigo O, Steill J, Swanson S, Jiang P, Rhie A, Formenti G, Phillippy A, Harris R, Wood J, Howe K, Kirilenko B, Munegowda C, Hiller M, Jain A, Kihara D, Johnston J, Ionkov A, Raja K, Toh H, Lang A, Wolf M, Jarvis E, Thomson J, Chaisson M, Stewart R. A High-Quality Blue Whale Genome, Segmental Duplications, and Historical Demography. Molecular Biology And Evolution 2024, 41: msae036. PMID: 38376487, PMCID: PMC10919930, DOI: 10.1093/molbev/msae036.Peer-Reviewed Original ResearchConceptsLong-read RNA-seq dataBody sizePacBio long readsGiant body sizeRNA-seq dataGenome assemblyGenome sizeLong readsSegmental duplicationsManual curationGenomeIsolation dateHistorical demographyBiological traitsInsulin-like growth factor 1 geneReference-qualityResistance to cancerBlue whale populationWhale populationsGenesBalaenoptera musculusInterglacial periodsBlue whalesConservation researchPhocoena sinus
2023
Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo
Akingbesote N, Leitner B, Jovin D, Desrouleaux R, Owusu D, Zhu W, Li Z, Pollak M, Perry R. Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo. ELife 2023, 12: e78335. PMID: 37219930, PMCID: PMC10205083, DOI: 10.7554/elife.78335.Peer-Reviewed Original ResearchConceptsMetabolic scalingMetabolic fluxMetabolic processesBody sizeMitochondrial metabolic processesMultiple cellular compartmentsVivo metabolic fluxesLevel of genesKey metabolic pathwaysProtein expressionMetabolic flux analysisAspects of metabolismCellular compartmentsGene expressionDifferential expressionMetabolic pathwaysGenesFlux analysisOxidative damageEnzyme activitySubstrate supplyFold rangeSpeciesExpressionMetabolic rateBeyond Cortex: The Evolution of the Human Brain
Chin R, Chang SWC, Holmes AJ. Beyond Cortex: The Evolution of the Human Brain. Psychological Review 2023, 130: 285-307. PMID: 35420848, DOI: 10.1037/rev0000361.Peer-Reviewed Original ResearchConceptsHuman brain evolutionBrain evolutionEvolutionary lineagesEvolutionary forcesEvolutionary pressureBody sizeHuman brain developmentHuman evolutionCurrent understandingBrain developmentDiverse setStudy of behaviorComprehensive viewBrain biologyLineagesEvolutionBiologyStriking increaseVast majorityCritical importanceAnimal modelsNonhuman primates
2021
Fluctuating asymmetry, a marker of poor growth quality, is associated with adult male metabolic rate
Longman D, Oyama S, Cracknell J, Thompson N, Gordon D, Stock J, Wells J. Fluctuating asymmetry, a marker of poor growth quality, is associated with adult male metabolic rate. American Journal Of Biological Anthropology 2021, 175: 646-655. PMID: 33768527, DOI: 10.1002/ajpa.24276.Peer-Reviewed Original ResearchConceptsEnergetic allocationLife-history traitsStrong selective pressureLarge body sizeLife history theoryEnergetic investmentAdult RMRSelective pressureMetabolic rateHistory theoryBody sizePhysiological functionsEvolutionary theoryMetabolic efficiencyMetabolic inefficiencyMetabolic costObserved interindividual variationHuman daily energy expenditureDaily energy expenditureGrowthFATraitsInterindividual variation
2020
The whale shark genome reveals how genomic and physiological properties scale with body size
Weber J, Park S, Luria V, Jeon S, Kim H, Jeon Y, Bhak Y, Jun J, Kim S, Hong W, Lee S, Cho Y, Karger A, Cain J, Manica A, Kim S, Kim J, Edwards J, Bhak J, Church G. The whale shark genome reveals how genomic and physiological properties scale with body size. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20662-20671. PMID: 32753383, PMCID: PMC7456109, DOI: 10.1073/pnas.1922576117.Peer-Reviewed Original ResearchConceptsWhale shark genomeShark genomeBody sizeGene lengthWhale sharksLarge-scale comparative genomic analysisLong neural genesMetazoan genome architectureSlow evolutionary rateComparative genomics approachLonger gene lengthComparative genomic analysisMultiple genetic featuresCodon adaptation indexMetabolic rateAverage geneGenome architectureNeurodegeneration genesEvolutionary ratesMost genomesGenomic approachesGenomic traitsNeural genesGenome featuresBiological traits
2018
High fat diet alters Drosophila melanogaster sexual behavior and traits: decreased attractiveness and changes in pheromone profiles
Schultzhaus J, Bennett C, Iftikhar H, Yew J, Mallett J, Carney G. High fat diet alters Drosophila melanogaster sexual behavior and traits: decreased attractiveness and changes in pheromone profiles. Scientific Reports 2018, 8: 5387. PMID: 29599496, PMCID: PMC5876352, DOI: 10.1038/s41598-018-23662-2.Peer-Reviewed Original ResearchConceptsSexual traitsMetabolic signaling pathwaysMating behaviorPheromone profilesHigh-fat dietSignaling pathwayMale mate preferenceSexual trait expressionGenetically tractable systemMale mating behaviorMate attractionPotential matesMate preferencesSevere behavioral defectsTrait expressionGenetic manipulationAnimal healthBody sizeMetabolic signalsBehavioral defectsMatingSexual cuesFemale attractivenessHFD effectsTraits
2016
Ecological and evolutionary influences on body size and shape in the Galápagos marine iguana (Amblyrhynchus cristatus)
Chiari Y, Glaberman S, Tarroso P, Caccone A, Claude J. Ecological and evolutionary influences on body size and shape in the Galápagos marine iguana (Amblyrhynchus cristatus). Oecologia 2016, 181: 885-894. PMID: 27041683, DOI: 10.1007/s00442-016-3618-1.Peer-Reviewed Original ResearchConceptsGalápagos marine iguanasMarine iguanasEvolutionary historyBody sizeGenetic adaptationBody size variationSexual dimorphismHigh morphological diversityStrong sexual dimorphismContribution of plasticityShape variationPhylogeographic patternsMultiple colonizationsEndemic speciesLocal adaptationEvolutionary changeMorphological diversityEvolutionary influencesDistribution rangeOceanic islandsSource populationIguanasEnvironmental conditionsSize variationMorphological measurementsMethionine restriction beyond life‐span extension
Ables GP, Hens JR, Nichenametla SN. Methionine restriction beyond life‐span extension. Annals Of The New York Academy Of Sciences 2016, 1363: 68-79. PMID: 26916321, DOI: 10.1111/nyas.13014.Peer-Reviewed Original ResearchConceptsMethionine restrictionLife span extensionPossible downstream effectorsMitochondrial oxidative stressAge-related diseasesCystathionine β-synthaseIntracellular regulatory mechanismsEpigenetic mechanismsNoncoding RNAsDownstream effectorsSpecific genesReactive oxygen speciesRegulatory mechanismsCell cycleBody sizeMethionine cycleEpigeneticsCancer progressionΒ-synthaseDietary methionine restrictionCell apoptosisFactor 1Fibroblast growth factor 21Hepatic glucose metabolismInsulin-like growth factor-1
2015
Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States
Barbour AG, Bunikis J, Fish D, Hanincová K. Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States. Parasites & Vectors 2015, 8: 299. PMID: 26024881, PMCID: PMC4459683, DOI: 10.1186/s13071-015-0903-5.Peer-Reviewed Original ResearchConceptsBody sizeLarge-sized mammalsMedium-sized mammalsDifferent mammalian speciesEastern North AmericaSpecies-specific PCRLyme disease agentSmall mammalsMammalian speciesWhite-footed mouseCommon raccoonSized mammalsMammalsBorrelia burgdorferiPine volesBody massGrey squirrelsVirginia opossumReservoir competenceEastern chipmunksIxodes scapularis ticksDisease agentsStriped skunksSpeciesNymphal Ixodes scapularis ticksA Quantitative Analysis of Growth and Size Regulation in Manduca sexta: The Physiological Basis of Variation in Size and Age at Metamorphosis
Grunert L, Clarke J, Ahuja C, Eswaran H, Nijhout H. A Quantitative Analysis of Growth and Size Regulation in Manduca sexta: The Physiological Basis of Variation in Size and Age at Metamorphosis. PLOS ONE 2015, 10: e0127988. PMID: 26011714, PMCID: PMC4444085, DOI: 10.1371/journal.pone.0127988.Peer-Reviewed Original ResearchConceptsAdult body sizeBody sizeImportant life-history traitsLife-history traitsHistory traitsAdult insectsTemperature-dependent mannerGenetic strainsLarval growthSize regulationDevelopmental mechanismsDevelopment timeLarval lifeMore moultsManduca sextaLarval instarsLarval moltThreshold sizeSize incrementInstarsGrowth rate declinesGrowth phaseMoultPhysiological basisCritical weight
2012
Differential impact of nutrition on developmental and metabolic gene expression during fruiting body development in Neurospora crassa
Wang Z, Lehr N, Trail F, Townsend JP. Differential impact of nutrition on developmental and metabolic gene expression during fruiting body development in Neurospora crassa. Fungal Genetics And Biology 2012, 49: 405-413. PMID: 22469835, PMCID: PMC3397380, DOI: 10.1016/j.fgb.2012.03.004.Peer-Reviewed Original ResearchConceptsCarrot agarPerithecial developmentNeurospora crassaNutritional resourcesCore metabolic genesDifferent fungiSexual developmentDiverse environmental stimuliMetabolic gene expressionKey regulatory roleDevelopmental programMetabolic genesMicroarray hybridizationTranscriptional profilesAnabolic pathwaysExpression patternsGene expressionBody sizeMetabolic differentiationRegulatory roleBody developmentEffects of nutritionNutritional environmentEnvironmental stimuliBody morphology
2009
Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae*
Tommasini SM, Hu B, Nadeau JH, Jepsen KJ. Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae*. Journal Of Bone And Mineral Research 2009, 24: 606-620. PMID: 19063678, PMCID: PMC2659510, DOI: 10.1359/jbmr.081224.Peer-Reviewed Original ResearchConceptsQuantitative trait lociBody sizeBone traitsPhenotypic integrationTrait covariationComplex traitsTrait lociMultiple traitsGenetic analysisDifferent traitsEnvironmental perturbationsSkeletal traitsTrabecular traitsAXB/BXAC57BL/6J genomeRI panelNonrandom setTraitsCompensatory interactionsGenetic variantsAdaptive responseB6 genomeRelative amountsGenomeCompositional traitsEvolution of Reproductive Morphology in Leaf Endophytes
Wang Z, Johnston PR, Yang ZL, Townsend JP. Evolution of Reproductive Morphology in Leaf Endophytes. PLOS ONE 2009, 4: e4246. PMID: 19158947, PMCID: PMC2617777, DOI: 10.1371/journal.pone.0004246.Peer-Reviewed Original ResearchConceptsLeaf endophytesEcological roleDead host tissuesCommon developmental pathwayEndophytic lifestyleAsexual developmentSaprobic speciesReproductive structuresReproductive morphologySaprobic fungiFungal tissueFungal classificationDead woodEndophytic fungiDevelopmental pathwaysBody sizeFungal morphologySignificant divergenceLeotiomycetesFungiEndophytesHost tissuesProblematic groupRhytismatalesImportant role
2008
Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
Dong X, Copps K, Guo S, Li Y, Kollipara R, DePinho R, White M. Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation. Cell Metabolism 2008, 8: 65-76. PMID: 18590693, PMCID: PMC2929667, DOI: 10.1016/j.cmet.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsEndocrine GlandsFoodForkhead Transcription FactorsGrowthHomeostasisInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceIntracellular Signaling Peptides and ProteinsLiverMiceMice, KnockoutNerve Tissue ProteinsPhosphoproteinsSignal TransductionConceptsInsulin signalingForkhead transcription factor FOXO1Insulin-regulated glucose homeostasisExpression of genesTranscription factor FOXO1Endocrine growth regulationNutrient homeostasisMetabolic genesStress resistancePerturbed expressionActive FoxO1Growth regulationLiver-specific deletionHepatic FoxO1Hepatic insulin resistanceBody sizePI3KHepatic Irs1FOXO1TranscriptomeSomatic growthDKO miceGenesSignalingHomeostasis
2002
The evolutionary origin of Indian Ocean tortoises (Dipsochelys)
Palkovacs E, Gerlach J, Caccone A. The evolutionary origin of Indian Ocean tortoises (Dipsochelys). Molecular Phylogenetics And Evolution 2002, 24: 216-227. PMID: 12144758, DOI: 10.1016/s1055-7903(02)00211-7.Peer-Reviewed Original ResearchConceptsWestern Indian Ocean islandsGiant tortoisesIndian Ocean islandsIndian Ocean giant tortoisesIndian OceanCyt b geneDNA substitution ratesOcean islandsShort generation timeSmall body sizeSource of colonizationMalagasy lineagesEvolutionary originWestern Indian OceanWild populationsMitochondrial DNAPhylogenetic analysisSequence evolutionB geneSubstitution ratesBody sizeOcean currentsEast coastGeneration timeTortoises
1998
Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida.
Glass G, Livingstone W, Mills J, Hlady W, Fine J, Biggler W, Coke T, Frazier D, Atherley S, Rollin P, Ksiazek T, Peters C, Childs J. Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida. American Journal Of Tropical Medicine And Hygiene 1998, 59: 699-703. PMID: 9840584, DOI: 10.4269/ajtmh.1998.59.699.Peer-Reviewed Original Research
1996
Developmental dissociation of excitability and secretory ability in Aplysia bag cell neurons
Nick T, Moreira J, Kaczmarek L, Carew T, Wayne N. Developmental dissociation of excitability and secretory ability in Aplysia bag cell neurons. Journal Of Neurophysiology 1996, 76: 3351-3359. PMID: 8930278, DOI: 10.1152/jn.1996.76.5.3351.Peer-Reviewed Original ResearchConceptsBag cell neuronsEgg-laying behaviorCell neuronsPotential functional significanceAplysia bag cell neuronsDevelopmental regulationVesicular localizationSecretory vesiclesJuvenile AplysiaPremature expressionImmature neuronsDownstream elementsMature formBody sizeReproductive behaviorImmunoelectron microscopyPotassium channel blocker tetraethylammoniumLarge vesiclesDevelopmental interactionsFunctional significanceBag cell hormonesVesiclesCessation of locomotionMature neuronsElectrical activity
1987
Adult Survivorship, Population Density, and Body Size in Sympatric Populations of Aedes triseriatus and Aedes hendersoni (Diptera: Culicidae)
Walker E, Copeland R, Paulson S, Munstermann L. Adult Survivorship, Population Density, and Body Size in Sympatric Populations of Aedes triseriatus and Aedes hendersoni (Diptera: Culicidae). Journal Of Medical Entomology 1987, 24: 485-493. PMID: 3625723, DOI: 10.1093/jmedent/24.4.485.Peer-Reviewed Original ResearchConceptsA. triseriatusAedes triseriatusLongevity of malesSympatric populationsIsozyme electrophoresisLow recapture ratesAdult survivorshipBody sizeRecapture ratesRecapture methodHendersoniFirst gonotrophic cycleTriseriatusAedes hendersoniSpeciesGonotrophic cyclePopulation densityTriseriatus femalesNorthern IndianaCockerellEcologyWildElectrophoresisFemalesLongevity
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