2024
Substrate geometry and topography induce F-actin reorganization and chiral alignment in an adherent model cortex
Sakamoto R, Murrell M. Substrate geometry and topography induce F-actin reorganization and chiral alignment in an adherent model cortex. Cell Reports Physical Science 2024, 5: 102338. DOI: 10.1016/j.xcrp.2024.102338.Peer-Reviewed Original ResearchF-actin organizationF-actin networkF-actinF-actin reorganizationSubstrate featuresActin cortexCytoskeletal organizationGiant unilamellar vesiclesIntracellular signalingCell adhesionGeometry sensingLiposome shapeCell membraneMembrane deformationUnilamellar vesiclesAdherent liposomeCellsActinOrganizationVesiclesAdhesionLiposomesMechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model
Sakamoto R, Murrell M. Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model. Nature Communications 2024, 15: 9731. PMID: 39523366, PMCID: PMC11551154, DOI: 10.1038/s41467-024-53228-y.Peer-Reviewed Original ResearchConceptsMyosin-induced stressContractile ring assemblyCell division mechanismActin filamentsActin cortexCleavage furrowDivision planeActomyosin flowsGiant unilamellar vesiclesRing assemblyCell divisionMyosin activityContractile ring-like structureShape changesRing-like structureDivision mechanismEnergetic costSymmetric divisionActinRing-like formationCell modelUnilamellar vesiclesIn vitro modelFurrowCellsComposite branched and linear F-actin maximize myosin-induced membrane shape changes in a biomimetic cell model
Sakamoto R, Murrell M. Composite branched and linear F-actin maximize myosin-induced membrane shape changes in a biomimetic cell model. Communications Biology 2024, 7: 840. PMID: 38987288, PMCID: PMC11236970, DOI: 10.1038/s42003-024-06528-4.Peer-Reviewed Original ResearchConceptsF-actin networkF-actinF-actin architectureMembrane shape changesCell shape changesActivity of myosinInduce membrane deformationActomyosin contractilityShape changesActin cortexActomyosin cortexGiant unilamellar vesiclesActinMembrane deformationUnilamellar vesiclesCell modelNo-slip boundariesForce generationActomyosinMyosinVesiclesForce transmissionGrowth‐induced collective bending and kinetic trapping of cytoskeletal filaments
Banerjee D, Freedman S, Murrell M, Banerjee S. Growth‐induced collective bending and kinetic trapping of cytoskeletal filaments. Cytoskeleton 2024, 81: 409-419. PMID: 38775207, PMCID: PMC12039077, DOI: 10.1002/cm.21877.Peer-Reviewed Original ResearchActin networkFilamentous growthActin filamentsTurnover of actin filamentsActin filament growthKinetic trapsActin poolFilament polymerizationActin cortexCytoskeletal filamentsSubunit poolActinFilamentsSubunitConsequence of growthFilament mechanismNematic defectsCrowded environmentLong-livedGrowthPoolAbundanceBending patternCellsTurnover
2023
Cell protrusions and contractions generate long-range membrane tension propagation
De Belly H, Yan S, Borja da Rocha H, Ichbiah S, Town J, Zager P, Estrada D, Meyer K, Turlier H, Bustamante C, Weiner O. Cell protrusions and contractions generate long-range membrane tension propagation. Cell 2023, 186: 3049-3061.e15. PMID: 37311454, PMCID: PMC10330871, DOI: 10.1016/j.cell.2023.05.014.Peer-Reviewed Original ResearchConceptsActomyosin contractionPropagation of membrane tensionDual-trap optical tweezersMembrane tensionActin-driven protrusionsActin-based protrusionsCell membraneOptical tweezersActin cortexCell protrusionsCell polarityMembrane flowCell physiologyTension propagationActomyosinTension transmissionCellsMembraneMechanical forcesPropagationProtrusionTweezersActinPolarization
2014
Mechanism of Cytokinetic Contractile Ring Constriction in Fission Yeast
Stachowiak MR, Laplante C, Chin HF, Guirao B, Karatekin E, Pollard TD, O’Shaughnessy B. Mechanism of Cytokinetic Contractile Ring Constriction in Fission Yeast. Developmental Cell 2014, 29: 547-561. PMID: 24914559, PMCID: PMC4137230, DOI: 10.1016/j.devcel.2014.04.021.Peer-Reviewed Original Research
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