2005
Quantitative Modeling of Chloride Conductance in Yeast TRK Potassium Transporters
Rivetta A, Slayman C, Kuroda T. Quantitative Modeling of Chloride Conductance in Yeast TRK Potassium Transporters. Biophysical Journal 2005, 89: 2412-2426. PMID: 16040756, PMCID: PMC1366741, DOI: 10.1529/biophysj.105.066712.Peer-Reviewed Original ResearchConceptsTrk proteinTrk potassium transportersPotassium transportersYeast spheroplastsPlasma membraneCentral poreNegative membrane voltagesProteinActive accumulationChloride conductanceChloride currentsMembrane dielectricMembrane voltageSaccharomycesSpheroplastsFungiPlantsTransportersBacteriaConductanceMembrane slope conductanceHypothetical structural modelStructural modelMembraneSlope conductance
2004
Functional and Molecular Characterization of a Volume-activated Chloride Channel in Rabbit Corneal Epithelial Cells
Al-Nakkash L, Iserovich P, Coca-Prados M, Yang H, Reinach P. Functional and Molecular Characterization of a Volume-activated Chloride Channel in Rabbit Corneal Epithelial Cells. The Journal Of Membrane Biology 2004, 201: 41-49. PMID: 15635811, DOI: 10.1007/s00232-004-0706-5.Peer-Reviewed Original ResearchConceptsCorneal epithelial cellsRabbit corneal epithelial cellsVolume-regulated anion channelsEpithelial cellsVoltage-dependent inhibitionHypotonic challengeVolume-activated chloride channelsRegulatory volume decrease (RVD) responseInactive phorbol ester analoguePresence of DIDSExtracellular calciumChloride currentsNiflumic acidRVD responseCell swellingDecrease responseNorthern blot analysisBlot analysisPhorbol dibutyratePhorbol ester analogsChloride channelsVACCNPPBMOsm mediumSV40-immortalized rabbit corneal epithelial cells
2003
Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes*
Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavell R. Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes*. Journal Of Biological Chemistry 2003, 278: 39443-39451. PMID: 12878608, DOI: 10.1074/jbc.m304879200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBase SequenceCell DivisionChloride ChannelsDNAFemaleGene ExpressionIon TransportKv1.3 Potassium ChannelLymphocyte ActivationMaleMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutPatch-Clamp TechniquesPotassium ChannelsPotassium Channels, Voltage-GatedRNA, MessengerT-LymphocytesConceptsWild-type cellsKv1.3-/- micePotassium channel subunitsVoltage-gated potassium channelsMouse thymocyte subsetsChloride currentsChannel subunitsAnion currentsT-cell activation/proliferationVoltage-dependent potassium currentsVolume regulationCell proliferationThymocyte apoptosisT cell responsesCell-mediated cytotoxicityObvious defectsCell activation/proliferationImmune system defectsT cell proliferationActivation/proliferationPotassium channelsLymph nodesCompensatory effectLymphocyte typeKv1.3
1998
Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons
Clark S, Jordt S, Jentsch T, Mathie A. Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons. The Journal Of Physiology 1998, 506: 665-678. PMID: 9503329, PMCID: PMC2230754, DOI: 10.1111/j.1469-7793.1998.665bv.x.Peer-Reviewed Original ResearchConceptsSCG neuronsRat superior cervical ganglion neuronsChloride currentsSuperior cervical ganglion neuronsConventional whole-cell recordingRat SCG neuronsClC-2Rat cerebellar granule cellsRat sympathetic neuronsPerforated-patch recordingsWhole-cell recordingsHyperpolarization-activated chloride currentCerebellar granule cellsTranscriptase-polymerase chain reaction experimentsPresence of mRNAGanglion neuronsSympathetic neuronsGABAA receptorsMM cesiumGranule cellsEffective blockerExternal potassium concentrationCl- currentInternal chloride concentrationHyperpolarization-activated Cl- currentExpression of voltage-activated chloride currents in acute slices of human gliomas
Ullrich N, Bordey A, Gillespie GY, Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 1998, 83: 1161-1173. PMID: 9502255, DOI: 10.1016/s0306-4522(97)00456-9.Peer-Reviewed Original ResearchConceptsAcute slicesChloride currentsGlioma cellsGrade tumorsGlial cellsPatient biopsiesWhole-cell patch-clamp recordingsChloride channelsHost glial cellsImplanted glioma cellsPathological tumor gradeLow-grade tumorsHigh-grade tumorsPatch-clamp recordingsSpecific Cl- channelsNormal glial cellsAstrocyte-like cellsShort-term cultureTumor gradePathological gradeSCID miceVoltage-activated sodiumIntracranial injectionPotassium currentExperimental tumors
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