2022
Heterogeneity of Acetylcholine Receptor Autoantibody–Mediated Complement Activity in Patients With Myasthenia Gravis
Obaid AH, Zografou C, Vadysirisack DD, Munro-Sheldon B, Fichtner ML, Roy B, Philbrick WM, Bennett JL, Nowak RJ, O'Connor KC. Heterogeneity of Acetylcholine Receptor Autoantibody–Mediated Complement Activity in Patients With Myasthenia Gravis. Neurology Neuroimmunology & Neuroinflammation 2022, 9: e1169. PMID: 35473886, PMCID: PMC9128035, DOI: 10.1212/nxi.0000000000001169.Peer-Reviewed Original ResearchConceptsAChR autoantibodiesMyasthenia gravisDisease burdenComplement activityAcetylcholine receptor autoantibodiesAChR-MG patientsComplement inhibitor therapyLower autoantibody levelsClinical disease scoresSubset of patientsHealthy donor samplesCell-based assaysMost patient samplesMembrane attack complex formationModest positive associationMG subtypesAutoantibody levelsAutoantibody titersComplement membrane attack complex formationMG patientsInhibitor therapyReceptor autoantibodiesHD groupTherapeutic responseMAC formation
2009
Energy Intake and Risk of Postmenopausal Breast Cancer: An Expanded Analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort
Sue LY, Schairer C, Ma X, Williams C, Chang SC, Miller AB, McCarty CA, Willcox BJ, Ziegler RG. Energy Intake and Risk of Postmenopausal Breast Cancer: An Expanded Analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 2842-2850. PMID: 19843674, PMCID: PMC2783562, DOI: 10.1158/1055-9965.epi-09-0087.Peer-Reviewed Original ResearchConceptsFood frequency questionnaireOvarian Cancer Screening Trial (PLCO) cohortPostmenopausal breast cancerBreast cancerEnergy intakeTrial cohortDietary assessmentIncident breast cancerBody mass indexBreast cancer riskFirst food frequency questionnaireLower energy intakeModest positive associationMultivariate RRsFrequency questionnaireHighest quartileMass indexLowest quartilePhysical activitySimilar riskCancer riskHuman studiesAge 55CancerAnimal experiments
1998
Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study
Platz E, Giovannucci E, Rimm E, Curhan G, Spiegelman D, Colditz G, Willett W. Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study. American Journal Of Epidemiology 1998, 147: 1140-1144. PMID: 9645792, DOI: 10.1093/oxfordjournals.aje.a009412.Peer-Reviewed Original ResearchConceptsHealth Professionals FollowBirth weightProstate cancerProfessionals FollowProstate cancer incidenceMultivariate logistic modelModest positive associationGrade tumorsProstatic cancerCancer incidenceRelative riskRetrospective analysisOverall associationCancerPositive associationFollowAssociationLogistic modelWeightTumorsIncidence
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