2025
FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
Gliniak C, Gordillo R, Youm Y, Lin Q, Crewe C, Zhang Z, Field B, Fujikawa T, Virostek M, Zhao S, Zhu Y, Rosen C, Horvath T, Dixit V, Scherer P. FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression. Cell Metabolism 2025, 37: 1547-1567.e6. PMID: 40527315, DOI: 10.1016/j.cmet.2025.05.011.Peer-Reviewed Original ResearchInflammatory immune cellsVisceral adipose tissueDiet-induced obesityAged transgenic miceHigh-fat dietAbsence of adiponectinTreat metabolic syndromeFibroblast growth factor 21Immune cellsLipotoxic ceramidesMetabolic syndromeReduced liver steatosisTransgenic miceMetabolic profileMetabolic benefitsInsulin sensitivityLiver steatosisIn adulthoodAdipose tissueMiceFat tissueImprove metabolismGrowth suppressionMetabolic issuesAge-related diseases
2024
1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice
SRODA N, VIJAYAKUMAR A, MURAKAMI E, WENG S, SHULMAN G, MYERS R, SUBRAMANIAN M. 1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice. Diabetes 2024, 73 DOI: 10.2337/db24-1637-p.Peer-Reviewed Original ResearchEnergy intakeWeight lossEnergy expenditureRespiratory exchange ratioMitochondrial protonophoreObese miceDose-dependent weight lossReduced oral intakeData support evaluationDays of dosingC57 BL/6 miceDiet-induced obese miceNegative energy balanceMale C57 BL/6 miceIncreased energy expenditureWhole-body lipid utilizationCompared to pre-treatmentHigh-fat dietOral intakePo bidBL/6 miceIndirect calorimetryMetabolic benefitsLipid utilizationVEH
2023
Trajectory of Gonadal Hormones in Adolescent Males up to 2 Years After Sleeve Gastrectomy
Kaur S, Bredella M, Misra M, Singhal V. Trajectory of Gonadal Hormones in Adolescent Males up to 2 Years After Sleeve Gastrectomy. Obesity Surgery 2023, 33: 3323-3326. PMID: 37561269, DOI: 10.1007/s11695-023-06759-0.Peer-Reviewed Original ResearchConceptsSertoli cell functionAssociated with degree of weight lossDegree of weight lossLeydig cell functionSleeve gastrectomyCell functionEffects of SGAssociated with degreeLong-term follow-up studiesWeight lossMale fertilitySertoliFollow-up studyNonsurgical controlsSG groupYoung adult malesTestosterone levelsGonadal hormonesMetabolic benefitsLeydigGastrectomyAdult malesAdolescentsTestisPreliminary study
2022
Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance
Huang Y, Zhou JH, Zhang H, Canfrán-Duque A, Singh AK, Perry RJ, Shulman G, Fernandez-Hernando C, Min W. Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance. Journal Of Clinical Investigation 2022, 132 PMID: 35202005, PMCID: PMC9057632, DOI: 10.1172/jci148852.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT inflammationInsulin resistanceMitochondrial reactive oxygen speciesReactive oxygen speciesAberrant innate immune responsesDiet-induced insulin resistanceSystematic metabolismDiet-induced obesityNLRP3 inflammasome pathwayWhole-body energy metabolismCGAS/STINGInnate immune responseFatty acid oxidationExcessive mitochondrial reactive oxygen speciesMetabolic benefitsImmune responseInflammasome pathwayAdipose tissueInflammationInhibition reversesLipid uptakeLipid metabolismThioredoxin 2Adaptive thermogenesis
2020
Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence
Parent M, Chitturi J, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence. Journal Of Neurotrauma 2020, 37: 966-974. PMID: 31830867, PMCID: PMC7175625, DOI: 10.1089/neu.2019.6486.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryKaempferol treatmentDiffusion tensor imagingFractional anisotropyBrain injuryParenchymal microstructureCallosal fractional anisotropyInterhemispheric structural connectivityH post-TBINeural connectivitySelect brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingTBI prognosisCerebrovascular reactivityFunctional outcomeImaging outcomesNeurovascular couplingPost-TBITBI outcomesTBI pathophysiologyMetabolic benefitsResting-state functional connectivity networksRsFC changesWhole brain
2017
High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage
Gaspar R, Botezelli J, Kuga G, Muñoz V, Coope A, Pereira R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage. Drug Development Research 2017, 78: 203-209. PMID: 28718949, DOI: 10.1002/ddr.21394.Peer-Reviewed Original ResearchConceptsMetabolic disordersHigh dosesRole of VitDVitamin D deficiencyImportant therapeutic targetD deficiencyRenal damageObese miceC57BL/6J miceInsulin sensitivityMetabolic benefitsTherapeutic strategiesTherapeutic targetVitDMiceDosesBody massDisordersLarge proportionCalcitriolObeseKidneyDiseaseDoseAdministration
2014
Boosting Metabolism by Sweetening the Gut
Eid T. Boosting Metabolism by Sweetening the Gut. Science Translational Medicine 2014, 6 DOI: 10.1126/scitranslmed.3008647.Peer-Reviewed Original Research
2012
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism. Physiological Reviews 2012, 92: 1479-1514. PMID: 22811431, PMCID: PMC3746174, DOI: 10.1152/physrev.00022.2011.Peer-Reviewed Original ResearchConceptsSirtuin 1Sirtuin 3Nonalcoholic fatty liver diseaseMammalian sirtuin 1Multiple metabolic benefitsFatty liver diseaseDiet-induced obesityType 2 diabetesActivation of sirtuinsLiver diseaseCellular energy storesMetabolic benefitsMetabolic disordersPharmacological meansEnergy homeostasisPhysiological modulatorDependent deacetylasesMetabolic processesSirtuinsCellular energy homeostasisEnergy storesCellular sensorsEnergy statusAnabolic processesCatabolic process
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