2024
Mechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2019
Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels
Khoo AS, Valentin TM, Leggett SE, Bhaskar D, Bye EM, Benmelech S, Ip BC, Wong IY. Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels. ACS Biomaterials Science & Engineering 2019, 5: 4341-4354. PMID: 31517039, PMCID: PMC6739834, DOI: 10.1021/acsbiomaterials.9b00519.Peer-Reviewed Original ResearchCell-matrix adhesionStrong cell-matrix adhesionMesenchymal morphologyCancer cell transitionCancer cellsCollagen I concentrationAmoeboid morphologyMetastatic breast cancer cellsCancer cell migrationCytoskeletal functionECM protein concentrationMigration phenotypeAmoeboid migrationCell transitionMesenchymal migrationBiochemical cuesBreast cancer cellsCell migrationExtracellular matrixRounded morphologyBiphasic dependencePlate formatCollagen ICellsBiomaterial platform
2012
Macrophage Mesenchymal Migration Requires Podosome Stabilization by Filamin A*
Guiet R, Vérollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, Calderwood DA, Glogauer M, Lutz PG, Maridonneau-Parini I. Macrophage Mesenchymal Migration Requires Podosome Stabilization by Filamin A*. Journal Of Biological Chemistry 2012, 287: 13051-13062. PMID: 22334688, PMCID: PMC3339984, DOI: 10.1074/jbc.m111.307124.Peer-Reviewed Original ResearchConceptsFilamin AMesenchymal migrationEmbryonic developmentPodosome rosette formationCell migrationMesenchymal migration modeCertain cell typesPodosome stabilityScaffold proteinActin polymerizationAmoeboid migrationNull mutationPodosomesActin filamentsMigratory cellsAmoeboid modeCell typesOrgan defectsMigration modesNew functionsThree-dimensional environmentMutationsProteaseStrong consequencesFLNA mutations
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