Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum
Saberian P, Nasiri H, Kaffashian F, Nasiriansari P, Nasab F, Mehrvarz N, Talebizadeh F, Shakeri S, Mayeli M, Initiative F. Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum. IBRO Neuroscience Reports 2025, 18: 732-738. PMID: 40476223, PMCID: PMC12139489, DOI: 10.1016/j.ibneur.2025.04.018.Peer-Reviewed Original ResearchPolygenic hazard scoreDMN connectivityMild cognitive impairmentAlzheimer's diseaseAlzheimer's Disease Neuroimaging InitiativeDefault mode network connectivityNo significant indirect effectsAD groupLight chainMode network connectivityGenetic risk burdenResting-state fMRIBrain network connectivityMild cognitive impairment groupPlasma NfL levelsPotential mediator roleHazard scoreAlzheimer's disease continuumProgressive cognitive declineMediation modelRs-fMRIMediation analysisPlasma NfLCognitive stagesDMN
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