2025
Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum
Saberian P, Nasiri H, Kaffashian F, Nasiriansari P, Nasab F, Mehrvarz N, Talebizadeh F, Shakeri S, Mayeli M, Initiative F. Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum. IBRO Neuroscience Reports 2025, 18: 732-738. PMID: 40476223, PMCID: PMC12139489, DOI: 10.1016/j.ibneur.2025.04.018.Peer-Reviewed Original ResearchPolygenic hazard scoreDMN connectivityMild cognitive impairmentAlzheimer's diseaseAlzheimer's Disease Neuroimaging InitiativeDefault mode network connectivityNo significant indirect effectsAD groupLight chainMode network connectivityGenetic risk burdenResting-state fMRIBrain network connectivityMild cognitive impairment groupPlasma NfL levelsPotential mediator roleHazard scoreAlzheimer's disease continuumProgressive cognitive declineMediation modelRs-fMRIMediation analysisPlasma NfLCognitive stagesDMN
2022
Differential expression of MicroRNAs in Alzheimer’s disease: a systematic review and meta-analysis
Yoon S, Kim S, Ko Y, Jeong G, Lee K, Lee J, Solmi M, Jacob L, Smith L, Stickley A, Carvalho A, Dragioti E, Kronbichler A, Koyanagi A, Hong S, Thompson T, Oh H, Salazar de Pablo G, Radua J, Shin J, Fusar-Poli P. Differential expression of MicroRNAs in Alzheimer’s disease: a systematic review and meta-analysis. Molecular Psychiatry 2022, 27: 2405-2413. PMID: 35264731, DOI: 10.1038/s41380-022-01476-z.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentAlzheimer's diseaseAccumulation of amyloid plaquesFunctional enrichment pathway analysisHealthy controlsFunctional enrichment analysisAD relative to HCHyperphosphorylated tauAmyloid plaquesMild cognitive impairment patientsEnrichment analysisMeta-analysesPathway analysisDifferential expressionMiRNA levelsUpregulated pathwaysProgressive cognitive declineNeurodegenerative diseasesCognitive impairmentCognitive declineAD patientsMiRNAsTherapeutic targetAssessment of publication biasRandom-effects meta-analyses
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