2020
Exploring the Mechanisms of Selectivity for Environmentally Significant Oxo-Anion Removal during Water Treatment: A Review of Common Competing Oxo-Anions and Tools for Quantifying Selective Adsorption
Pincus L, Rudel H, Petrović P, Gupta S, Westerhoff P, Muhich C, Zimmerman J. Exploring the Mechanisms of Selectivity for Environmentally Significant Oxo-Anion Removal during Water Treatment: A Review of Common Competing Oxo-Anions and Tools for Quantifying Selective Adsorption. Environmental Science And Technology 2020, 54: 9769-9790. PMID: 32515947, PMCID: PMC10514893, DOI: 10.1021/acs.est.0c01666.Peer-Reviewed Original ResearchConceptsSelective adsorbentDensity functional theorySelective adsorptionSelectivity of materialsOxo anionsNovel adsorbentCompetitive adsorptionElectrostatic interactionsSurface complexationMechanism of selectivityAdsorptive competitionSteric hindranceAdsorbentFunctional theoryAdsorptionSorption sitesWater treatmentSelectivityPollutant removal potentialRemoval potentialComplexationMechanistic approachMaterialsBase hardnessHindrance
2015
Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain
Mastorakos P, Song E, Zhang C, Berry S, Park H, Kim Y, Park J, Lee S, Suk J, Hanes J. Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain. Small 2015, 12: 678-685. PMID: 26680637, PMCID: PMC4913277, DOI: 10.1002/smll.201502554.Peer-Reviewed Original ResearchConceptsDNA nanoparticlesHigh-level transgene expressionTransgene expressionGene delivery platformSuccessful gene therapyConventional gene vectorsBrain-penetrating nanoparticlesPolyethylene glycol (PEG) coronaWidespread gene deliveryNanoparticle platformGene deliveryGene vectorsNanoparticlesDelivery platformGene therapyStable subTransgene expression patternsBiodegradable polymersConvection-enhanced deliveryPressure-driven flowDeliveryPlatformExtracellular matrixPromiseSteric hindrance
2009
The MoD-QM/MM methodology for structural refinement of photosystem II and other biological macromolecules
Sproviero EM, Newcomer MB, Gascón JA, Batista ER, Brudvig GW, Batista VS. The MoD-QM/MM methodology for structural refinement of photosystem II and other biological macromolecules. Photosynthesis Research 2009, 102: 455-470. PMID: 19633920, PMCID: PMC2954272, DOI: 10.1007/s11120-009-9467-6.Peer-Reviewed Original ResearchConceptsElectrostatic interactionsMM methodQuantum mechanics/molecular mechanics (QM/MM) hybrid methodsForce fieldQM/MM hybrid methodsQM/MM methodologyQM/MM methodsMolecular mechanics force fieldQuantum chemistry techniquesMM force fieldsStructural refinementPhotosystem IIChemistry techniquesStructure/function relationsCharge transferQM layerMolecular fragmentsChemical modificationBiological macromoleculesSteric hindranceComputational protocolSpectroscopic dataMolecular domainsStructural propertiesHigh-resolution spectroscopic data
1992
Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.
Farrell N, Kelland LR, Roberts JD, Van Beusichem M. Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action. Cancer Research 1992, 52: 5065-72. PMID: 1516063.Peer-Reviewed Original ResearchConceptsPlatinum antitumor complexesPlanar ligandsPyridine complexesAmmine complexesAntitumor complexesNew trans platinum complexesCell linesHuman tumor cell linesTrans-platinum complexesTumor cell linesPreliminary mechanistic studiesMurine L1210Rate of reactionFormula transMechanism of actionTrans complexesTrans geometryImportant biomoleculesSteric hindranceThymus DNAHuman tumor panelOvarian carcinoma cell linesCarcinoma cell linesPotential new classDNA synthesis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply