Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
Mastorakos P, Kambhampati S, Mishra M, Wu T, Song E, Hanes J, Kannan R. Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells. Nanoscale 2015, 7: 3845-3856. PMID: 25213606, PMCID: PMC4797994, DOI: 10.1039/c4nr04284k.Peer-Reviewed Original ResearchConceptsTransgene deliveryGene vectorsNon-viral gene vectorsHigh-level transgene expressionNon-viral gene deliveryGene delivery platformGene-based therapeuticsOcular gene therapyGene deliveryColloidal stabilityNumerous blinding disordersGene therapyRetinal pigment epitheliumTransgene expressionHuman RPE cellsDNA complexationVector surfacePolyamidoamine dendrimersCell uptakePEGylated dendrimersTriamcinolone acetonideImproved stabilityRPE cellsAmine groupsInherent drawbacks
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