2015
Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
Mastorakos P, Kambhampati S, Mishra M, Wu T, Song E, Hanes J, Kannan R. Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells. Nanoscale 2015, 7: 3845-3856. PMID: 25213606, PMCID: PMC4797994, DOI: 10.1039/c4nr04284k.Peer-Reviewed Original ResearchConceptsTransgene deliveryGene vectorsNon-viral gene vectorsHigh-level transgene expressionNon-viral gene deliveryGene delivery platformGene-based therapeuticsOcular gene therapyGene deliveryColloidal stabilityNumerous blinding disordersGene therapyRetinal pigment epitheliumTransgene expressionHuman RPE cellsDNA complexationVector surfacePolyamidoamine dendrimersCell uptakePEGylated dendrimersTriamcinolone acetonideImproved stabilityRPE cellsAmine groupsInherent drawbacks
2011
Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
Zhou J, Liu J, Cheng CJ, Patel TR, Weller CE, Piepmeier JM, Jiang Z, Saltzman WM. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials 2011, 11: 82-90. PMID: 22138789, PMCID: PMC4180913, DOI: 10.1038/nmat3187.Peer-Reviewed Original ResearchConceptsGene deliveryNon-viral gene deliveryEfficient gene deliveryGene delivery abilityTargeted gene deliveryHighest molecular weight terpolymerDelivery abilityTargeted deliveryLipofectamine 2000Dialkyl diesterVivo applicationsPolycationic vectorsSpecific ring sizesTRAIL geneHigh efficiencyCharge densityLow charge densityDeliveryPolyethylenimineMinimal toxicityEfficiencyHydrophobicityLactone contentDensityApplications
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply