Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain
Mastorakos P, Song E, Zhang C, Berry S, Park H, Kim Y, Park J, Lee S, Suk J, Hanes J. Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain. Small 2015, 12: 678-685. PMID: 26680637, PMCID: PMC4913277, DOI: 10.1002/smll.201502554.Peer-Reviewed Original ResearchConceptsDNA nanoparticlesHigh-level transgene expressionTransgene expressionGene delivery platformSuccessful gene therapyConventional gene vectorsBrain-penetrating nanoparticlesPolyethylene glycol (PEG) coronaWidespread gene deliveryNanoparticle platformGene deliveryGene vectorsNanoparticlesDelivery platformGene therapyStable subTransgene expression patternsBiodegradable polymersConvection-enhanced deliveryPressure-driven flowDeliveryPlatformExtracellular matrixPromiseSteric hindrance
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