Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
Mastorakos P, Kambhampati S, Mishra M, Wu T, Song E, Hanes J, Kannan R. Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells. Nanoscale 2015, 7: 3845-3856. PMID: 25213606, PMCID: PMC4797994, DOI: 10.1039/c4nr04284k.Peer-Reviewed Original ResearchConceptsTransgene deliveryGene vectorsNon-viral gene vectorsHigh-level transgene expressionNon-viral gene deliveryGene delivery platformGene-based therapeuticsOcular gene therapyGene deliveryColloidal stabilityNumerous blinding disordersGene therapyRetinal pigment epitheliumTransgene expressionHuman RPE cellsDNA complexationVector surfacePolyamidoamine dendrimersCell uptakePEGylated dendrimersTriamcinolone acetonideImproved stabilityRPE cellsAmine groupsInherent drawbacksClick synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
Zolotarskaya OY, Xu L, Valerie K, Yang H. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Advances 2015, 5: 58600-58608. PMID: 26640689, PMCID: PMC4669072, DOI: 10.1039/c5ra07987j.Peer-Reviewed Original ResearchCamptothecin prodrugEfficient click chemistryAnionic polyamidoamine dendrimersSustained drug deliveryClick synthesisClick chemistryClick reactionCoupling reactionMultifunctional dendrimersFree CPTPolyamidoamine dendrimersReaction efficiencyDrug deliveryMethyl-morpholinium chlorideDendrimersCPT conjugatesSlow releaseDimethyl sulfoxideAgent 4PropargylaminesChemistrySynthesisReactionDose-dependent toxicityHuman glioma cells
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply