2022
Strategies for Glycoengineering Therapeutic Proteins
Dammen-Brower K, Epler P, Zhu S, Bernstein ZJ, Stabach PR, Braddock DT, Spangler JB, Yarema KJ. Strategies for Glycoengineering Therapeutic Proteins. Frontiers In Chemistry 2022, 10: 863118. PMID: 35494652, PMCID: PMC9043614, DOI: 10.3389/fchem.2022.863118.Peer-Reviewed Original Research
2021
Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin
Wang G, Kitaoka T, Crawford A, Mao Q, Hesketh A, Guppy FM, Ash GI, Liu J, Gerstein MB, Pitsiladis YP. Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin. Scientific Reports 2021, 11: 21705. PMID: 34737331, PMCID: PMC8568984, DOI: 10.1038/s41598-021-00608-9.Peer-Reviewed Original ResearchConceptsRNA-seqDifferential gene expressionPathway enrichment analysisRNA biologyTranscriptomic profilingTarget genesEnrichment analysisGene expressionEPO biologyMicroarray platformGene correlateCross-platform comparisonGenesBiologyImmune regulationHuman erythropoietinTissue protectionProfilingRegulationErythropoietinRecombinant human erythropoietinExpressionImportant toolErythropoiesisOxygen transportA therapeutic vascular conduit to support in vivo cell-secreted therapy
Han EX, Qian H, Jiang B, Figetakis M, Kosyakova N, Tellides G, Niklason LE, Chang WG. A therapeutic vascular conduit to support in vivo cell-secreted therapy. Npj Regenerative Medicine 2021, 6: 40. PMID: 34326344, PMCID: PMC8322381, DOI: 10.1038/s41536-021-00150-2.Peer-Reviewed Original ResearchEnd-stage renal diseaseVascular conduitsLong-term efficacyVascular graftsHemoglobin levelsRenal diseaseCell-based therapiesMacrophage infiltrationCell transplantationHemodialysis accessAcellular vesselsLuminal obstructionSerum erythropoietinNude ratsClinical disordersCellular implantationEPO expressionErythropoietinGraftTherapyAdequate vascularizationBiological effects
2016
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. Journal Of Clinical Investigation 2016, 126: 1926-1938. PMID: 27088801, PMCID: PMC4855934, DOI: 10.1172/jci83551.Peer-Reviewed Original ResearchConceptsRenal interstitial cellsProlyl-4-hydroxylase domainInterstitial cellsRenal erythropoietinPHD2 inactivationPharmacologic PHD inhibitionHIF-2 activityDistinct subpopulationsHypoxia-inducible factor-2Interstitial fibroblast-like cellsFibroblast-like cellsRenal interstitiumPHD inhibitionStroma-derived cellsRenal EpoErythropoietinHeterozygous deficiencyEPO productionEPO synthesisFactor 2PHD3Cell plasticityCellular oxygen sensorsHypoxiaEPO induction
2013
Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression
Duman C, Newton S. Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression. Methods In Molecular Biology 2013, 982: 127-140. PMID: 23456866, DOI: 10.1007/978-1-62703-308-4_8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsForced-swim testNeurotrophic actionsNovel object recognition testPotential antidepressant propertiesTreatment of depressionTissue-protective propertiesObject recognition testPotential therapeutic utilityEffect of erythropoietinRodent behavioral modelsAntidepressant propertiesDepressive disorderRodent modelsTherapeutic utilityRodent behavioral assaysNeurotrophic compoundsHyponeophagia testErythropoietinCytokine erythropoietinDepressionImportant regulatorBehavioral assaysProtective propertiesRecognition testAntidepressants
2012
The Expression of EPOR in Renal Cortex during Postnatal Development
Xiao L, Li Z, Xu P, Li Z, Xu J, Yang Z. The Expression of EPOR in Renal Cortex during Postnatal Development. PLOS ONE 2012, 7: e41993. PMID: 22844537, PMCID: PMC3406037, DOI: 10.1371/journal.pone.0041993.Peer-Reviewed Original ResearchConceptsExpression of EPORRenal cortexEPO receptorRenal tubulesRenal corpusclesDay of birthMouse renal cortexImportant growth factorFibroblast-like cellsPostnatal dayPostnatal development processAnimal modelsAnatomical relationshipMature micePostnatal developmentCortexWestern blottingGrowth factorHigh expressionErythropoietinBrainP14Erythroid differentiationTubulesCorpuscles
2007
A Meta-analysis of Randomized Controlled Trials in Critically Ill Patients to Evaluate the Dose-Response Effect of Erythropoietin
Turaga K, Sugimoto J, Forse R. A Meta-analysis of Randomized Controlled Trials in Critically Ill Patients to Evaluate the Dose-Response Effect of Erythropoietin. Journal Of Intensive Care Medicine 2007, 22: 270-282. PMID: 17895485, DOI: 10.1177/0885066607304437.Peer-Reviewed Original ResearchConceptsCritically ill patientsDose-response effectRandomized clinical trialsClinical trialsIll patientsMeta-analysisChronic Health Evaluation (APACHE) II scoreMeta-analysis of randomized controlled trialsPooled estimatesHigh doses of erythropoietinDose of erythropoietinCurrent Controlled Trials RegisterControlled Trials RegisterEffect of erythropoietinRandomized Controlled TrialsAcute PhysiologyII scoreHigh dosesTrials RegisterErythropoietinControlled TrialsDose responseInclusion criteriaPatientsInclusion of studies
1997
796 Prevention of chemotherapy related anemia by recombinant human erythropoietin (EPO) in patients with small cell lung cancer (SCLC) receiving cyclophosphamide, doxorubicin, and etoposide (CAE) chemotherapy with G-SCF support
Crawford J, Blackwell S, Shoemaker D, Pupa M, Mulhausen T, Herndon J, Winer E, Flynn J, Dempsey H. 796 Prevention of chemotherapy related anemia by recombinant human erythropoietin (EPO) in patients with small cell lung cancer (SCLC) receiving cyclophosphamide, doxorubicin, and etoposide (CAE) chemotherapy with G-SCF support. Lung Cancer 1997, 18: 205. DOI: 10.1016/s0169-5002(97)80173-0.Peer-Reviewed Original Research
1993
Erythropoietin Therapy for Anemia of Prematurity
Gallagher P, Ehrenkranz R. Erythropoietin Therapy for Anemia of Prematurity. Clinics In Perinatology 1993, 20: 169-191. PMID: 8458164, DOI: 10.1016/s0095-5108(18)30418-4.Peer-Reviewed Original ResearchConceptsAnemia of prematurityRecombinant human erythropoietin administrationBiology of erythropoietinTreatment of anemiaRecombinant human erythropoietinErythropoietin therapyErythropoietin administrationClinical trialsNeonatal erythropoiesisPrematurityHuman erythropoietinValuable adjunctAnemiaTherapyErythropoietinTreatmentPathophysiologyAdjunctAdministrationTrials
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