2024
Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
Park J, Riaz M, Qin L, Zhang W, Batty L, Fooladi S, Kural M, Li X, Luo H, Xu Z, Wang J, Banno K, Gu S, Yuan Y, Anderson C, Ellis M, Zhou J, Luo J, Shi X, Shin J, Liu Y, Lee S, Yoder M, Elder R, Mak M, Thorn S, Sinusas A, Gruber P, Hwa J, Tellides G, Niklason L, Qyang Y. Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency. Cell Stem Cell 2024, 32: 137-143.e6. PMID: 39644899, PMCID: PMC11698629, DOI: 10.1016/j.stem.2024.11.006.Peer-Reviewed Original ResearchTissue-engineered vascular conduitsSingle-ventricle congenital heart defectsEndothelial cellsBiodegradable polymeric scaffoldsGraft patencyAutologous bone marrow cellsAntithrombotic functionCongenital heart defectsInferior vena cava graftHiPSC-derived endothelial cellsBone marrow cellsHuman umbilical arteryDecellularized human umbilical arteriesPolymeric scaffoldsHost endothelial cellsHuman induced pluripotent stem cell (hiPSC)-derived endothelial cellsUmbilical arteryHeart defectsVascular conduitsMarrow cellsFlow bioreactorVena cava graftNude ratsGraft stenosisClinical trials
2021
A therapeutic vascular conduit to support in vivo cell-secreted therapy
Han EX, Qian H, Jiang B, Figetakis M, Kosyakova N, Tellides G, Niklason LE, Chang WG. A therapeutic vascular conduit to support in vivo cell-secreted therapy. Npj Regenerative Medicine 2021, 6: 40. PMID: 34326344, PMCID: PMC8322381, DOI: 10.1038/s41536-021-00150-2.Peer-Reviewed Original ResearchEnd-stage renal diseaseVascular conduitsLong-term efficacyVascular graftsHemoglobin levelsRenal diseaseCell-based therapiesMacrophage infiltrationCell transplantationHemodialysis accessAcellular vesselsLuminal obstructionSerum erythropoietinNude ratsClinical disordersCellular implantationEPO expressionErythropoietinGraftTherapyAdequate vascularizationBiological effects
2016
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells
Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials 2016, 102: 120-129. PMID: 27336184, PMCID: PMC4939127, DOI: 10.1016/j.biomaterials.2016.06.010.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular diseaseBlood vesselsAlpha-smooth muscle actinSmooth muscle myosin heavy chainActive vascular remodelingSmooth muscle cellsMuscle myosin heavy chainTissue-engineered blood vesselsStem cellsAbundant collagenous matrixPluripotent stem cellsInterposition graftAllogeneic graftsVascular remodelingΑ-SMANude ratsMuscle actinMyosin heavy chainClinical useMuscle cellsFunctional vascular smooth muscle cellsPatientsFunctional tissue-engineered blood vesselGraft
2014
Xenotransplantation of whole pig ovaries into nude rats as an experimental model for fertility preservation
Dittrich R, Lotz L, Nichols-Burns S, Schneider H, Hoffmann I, Beckmann M. Xenotransplantation of whole pig ovaries into nude rats as an experimental model for fertility preservation. Geburtshilfe Und Frauenheilkunde 2014, 74 DOI: 10.1055/s-0034-1388573.Peer-Reviewed Original Research
2004
Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model
Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TCh, Friedlaender GE. Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model. Spine 2004, 29: 1612-1617. PMID: 15284503, DOI: 10.1097/01.brs.0000132512.53305.a1.Peer-Reviewed Original ResearchConceptsOP-1 PuttyFusion rateSpine fusion modelManual palpationOP-1Posterolateral lumbar spine fusionLumbar spine fusionSimilar fusion ratesAthymic nude ratsSpine fusion ratesLumbar fusion ratesAthymic rat modelIntertransverse process fusionBone graft alternativesInflammatory responseRat modelBACKGROUND DATASpine fusionStudy groupNude ratsOsteogenic protein-1Athymic ratsFusion massOsteoinductive productsGraft alternatives
2000
Evaluation of 11C-colchicine for PET imaging of multiple drug resistance.
Levchenko A, Mehta B, Lee J, Humm J, Augensen F, Squire O, Kothari P, Finn R, Leonard E, Larson S. Evaluation of 11C-colchicine for PET imaging of multiple drug resistance. Journal Of Nuclear Medicine 2000, 41: 493-501. PMID: 10716325.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesColchicineDrug Resistance, MultipleFlow CytometryHumansMiceMice, Inbred BALB CModels, TheoreticalNeuroblastomaRatsRats, NudeTissue DistributionTomography, Emission-ComputedTransplantation, HeterologousTumor Cells, CulturedConceptsResistant tumorsPET imagingMultiple drug resistance phenotypeDrug-resistant variantsQuality of lifeCell linesMultiple drug resistanceResistant cell linesC cell lineP-gp actionDrug resistance phenotypeEarly diagnosisNude ratsFDG scansTumorsP-glycoproteinDrug resistanceBiodistribution experimentsCytotoxic agentsChemotherapeutic interventionResistant strainsCancer cellsIntracellular accumulationVivo experimentsScans
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