2016
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. Journal Of Clinical Investigation 2016, 126: 1926-1938. PMID: 27088801, PMCID: PMC4855934, DOI: 10.1172/jci83551.Peer-Reviewed Original ResearchConceptsRenal interstitial cellsProlyl-4-hydroxylase domainInterstitial cellsRenal erythropoietinPHD2 inactivationPharmacologic PHD inhibitionHIF-2 activityDistinct subpopulationsHypoxia-inducible factor-2Interstitial fibroblast-like cellsFibroblast-like cellsRenal interstitiumPHD inhibitionStroma-derived cellsRenal EpoErythropoietinHeterozygous deficiencyEPO productionEPO synthesisFactor 2PHD3Cell plasticityCellular oxygen sensorsHypoxiaEPO induction
2005
Attenuation of Accumulation of Neointimal Lipid by Pioglitazone in Mice Genetically Deficient in Insulin Receptor Substrate-2 and Apolipoprotein E
Clough M, Schneider D, Sobel B, White M, Wadsworth M, Taatjes D. Attenuation of Accumulation of Neointimal Lipid by Pioglitazone in Mice Genetically Deficient in Insulin Receptor Substrate-2 and Apolipoprotein E. Journal Of Histochemistry & Cytochemistry 2005, 53: 603-610. PMID: 15872053, DOI: 10.1369/jhc.4a6590.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAortaApolipoproteins EArteriosclerosisHyperlipidemiasHypoglycemic AgentsInsulin Receptor Substrate ProteinsInsulin ResistanceIntracellular Signaling Peptides and ProteinsLipid MetabolismMiceMice, Inbred C57BLMice, KnockoutPhosphoproteinsPioglitazoneReceptor, InsulinThiazolidinedionesTunica IntimaConceptsInsulin resistanceApolipoprotein EAcute coronary syndromeVulnerable atherosclerotic plaquesInsulin receptor substrate 2Accumulation of lipidsCoronary syndromeProximal aortaInsulin sensitizersNeointimal accumulationAtheroma formationAortic intimaAtherosclerotic lesionsAtherosclerotic plaquesType 2PioglitazoneMiceLesionsCross-sectional areaHeterozygous deficiencyAtherogenesisSubstrate 2TreatmentLipidsAtheroma
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