2020
Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner.
Ito T, Kometani K, Minato N, Hamazaki Y. Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. The Journal Of Immunology 2020, 205: 2008-2015. PMID: 32907997, DOI: 10.4049/jimmunol.1901101.Peer-Reviewed Original ResearchConceptsImmune complexesHealthy miceBone marrowUptake of ICsEndothelial cellsAdministration of erythropoietinSoluble immune complexesLiver reticuloendothelial systemSinusoidal endothelial cellsBone marrow endothelial cellsMarrow endothelial cellsEPO administrationKupffer cellsTransgenic miceAnemic conditionBM erythroblastsReticuloendothelial systemSinusoidal vasculatureMiceBMECsEPO receptorHematopoietic cellsAdministrationEPOHematopoietic niche
2019
Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit
He L, Cohen EB, Edwards APB, Xavier-Ferrucio J, Bugge K, Federman RS, Absher D, Myers RM, Kragelund BB, Krause DS, DiMaio D. Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit. IScience 2019, 17: 167-181. PMID: 31279934, PMCID: PMC6614117, DOI: 10.1016/j.isci.2019.06.027.Peer-Reviewed Original ResearchErythropoietin receptorPrimary human hematopoietic progenitor cellsProtein aptamerGrowth factor independenceHuman hematopoietic progenitor cellsJAK/STATMurine BaF3 cellsTransmembrane domainCellular processesCytoplasmic tyrosinesCytoplasmic domainHematopoietic progenitor cellsErythroid differentiationBaF3 cellsCommon subunitFactor independenceSerum withdrawalCell deathCooperative signalingEPO receptorEPOR homodimersProgenitor cellsEssential roleSubunitsSignaling
2016
Discovery of the First Pathogenic Human EPO Mutation Provides Mechanistic Insight into Cytokine Signaling
Kim A, Ulirsch J, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Gupta N, Gabriel S, Lander E, Patiroglu T, Ozcan A, Ozdemir M, Garcia C, Piehler J, Gazda H, Klein D, Sankaran V. Discovery of the First Pathogenic Human EPO Mutation Provides Mechanistic Insight into Cytokine Signaling. Blood 2016, 128: 331. DOI: 10.1182/blood.v128.22.331.331.Peer-Reviewed Original ResearchDiamond-Blackfan anemiaWhole-exome sequencing dataEPO receptorPotent concentrationAllogeneic bone marrow transplantBone marrow transplantBone marrow failure disordersYears of ageIntracellular flow cytometryMarrow failure disordersSerum EPO levelsExome sequencing dataMajority of casesAnemia correctionHost diseaseSevere graftDonor chimerismRed blood cellsMarrow transplantResultant complicationsLow doseRare caseSide effectsPatientsBone marrow
2012
The Expression of EPOR in Renal Cortex during Postnatal Development
Xiao L, Li Z, Xu P, Li Z, Xu J, Yang Z. The Expression of EPOR in Renal Cortex during Postnatal Development. PLOS ONE 2012, 7: e41993. PMID: 22844537, PMCID: PMC3406037, DOI: 10.1371/journal.pone.0041993.Peer-Reviewed Original ResearchConceptsExpression of EPORRenal cortexEPO receptorRenal tubulesRenal corpusclesDay of birthMouse renal cortexImportant growth factorFibroblast-like cellsPostnatal dayPostnatal development processAnimal modelsAnatomical relationshipMature micePostnatal developmentCortexWestern blottingGrowth factorHigh expressionErythropoietinBrainP14Erythroid differentiationTubulesCorpuscles
2009
Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects
Girgenti MJ, Hunsberger J, Duman CH, Sathyanesan M, Terwilliger R, Newton SS. Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects. Biological Psychiatry 2009, 66: 267-274. PMID: 19185286, DOI: 10.1016/j.biopsych.2008.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBehavior, AnimalBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalElectroshockErythropoietinExploratory BehaviorGene Expression ProfilingGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitLocomotionMaleOligonucleotide Array Sequence AnalysisRatsRats, Sprague-DawleyReceptors, ErythropoietinSeizuresSwimmingConceptsElectroconvulsive seizuresBehavioral effectsNIH testEPO receptorTrophic effectsRobust antidepressant-like effectsAntidepressant-like behavioral effectsBrain-derived neurotrophic factorAntidepressant-like efficacyTranscription factor hypoxiaAntidepressant-like effectsMultiple brain regionsQuantitative polymerase chain reactionExpression of erythropoietinAntidepressant actionAntidepressant effectsPeripheral administrationNeurotrophic factorIntracerebroventricular infusionPolymerase chain reactionTrophic actionNeurotrophic genesAnimal modelsChoroid plexusRegulation of erythropoietin
2008
Erythropoietin expands a stromal cell population that can mediate renoprotection
Bi B, Guo J, Marlier A, Lin SR, Cantley LG. Erythropoietin expands a stromal cell population that can mediate renoprotection. American Journal Of Physiology. Renal Physiology 2008, 295: f1017-f1022. PMID: 18653480, PMCID: PMC2576137, DOI: 10.1152/ajprenal.90218.2008.Peer-Reviewed Original ResearchConceptsAdministration of EPOMarrow stromal cellsTubular epithelial cellsRenoprotective effectsTubular cellsCisplatin-treated miceEpithelial cellsEndothelial progenitor cellsSecretion of factorsStromal cell populationsDeprivation-induced cell deathRenal functionTubular injuryCisplatin administrationPeripheral circulationIntraperitoneal injectionSerum deprivation-induced cell deathToxic injuryBone marrowStromal cellsVivo expansionInjuryProgenitor cellsAdministrationEPO receptor
2001
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades
Digicaylioglu M, Lipton S. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades. Nature 2001, 412: 641-647. PMID: 11493922, DOI: 10.1038/35088074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell NucleusCells, CulturedDNAErythropoietinGenes, ReporterJanus Kinase 2N-MethylaspartateNeuronsNeuroprotective AgentsNF-kappa BNitric OxideProtein BindingProtein TransportProtein-Tyrosine KinasesProto-Oncogene ProteinsRatsReceptors, ErythropoietinSignal TransductionSuperoxide DismutaseTumor Necrosis Factor-alphaConceptsHypoxia-inducible factor-1EPO receptorForm of JAK2Transcription factor hypoxia-inducible factor-1NF-κB-dependent transcriptionNF-κB functionActivation of JAK2Subsequent nuclear translocationTranscription factor NF-κBNF-κBFactor NF-κBSignaling cascadesNitric oxideKinase 2NF-κB signaling cascadesHypoxic-ischemic preconditioningNuclear translocationNeuroprotective genesFactor 1JAK2Neuroprotective pathwaysNeuronal apoptosisCerebrocortical neuronsEPO effectsDegenerative damage
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